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Reactive Oxygen and Reactive Nitrogen Species in Herpesvirus Infections: Mechanisms, Clinical Implications, and Therapeutic Opportunities
(SAGE Publications, 2026-07-22)
Reyes-Ramírez, Rodrigo
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Navarro, Areli J.
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Ortiz, Gerardo E.
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Tognarelli, Eduardo I.
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López-Hernández, Dayesi
Significance: Herpesvirus infections are highly prevalent in the human population, causing a broad spectrum of diseases ranging from mild to severe that affect numerous tissues, although most infections remain asymptomatic. These viruses establish lifelong infections through latency and may reactivate at different frequencies, with or without clinical symptoms. To counteract microbial infections, host cells have evolved molecular mechanisms that interfere with viral replication, including the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Recent Advances: ROS and RNS are not merely antimicrobial products but also regulators of pathogen gene expression, immune modulation, and cell fate decisions, with excessive production leading to oxidative stress and cellular damage, among other effects. Notably, many viruses, including herpesviruses, modulate ROS and RNS production in infected cells to promote viral replication and evade the host immune response. Critical Issues: In this review, we examine the complex interplay between ROS, RNS, and herpesvirus infections. The available literature suggests (i) that herpesviruses from all three subfamilies exploit ROS and RNS as molecular switches for viral replication and immune evasion, (ii) that the specific ROS and RNS species and pathways hijacked by these viruses differ by subfamily, creating distinct and targetable redox vulnerabilities, and (iii) that antioxidant interventions selectively restoring physiological redox balances could represent efficacious antiviral strategies. Future Directions: Highlighting emerging therapeutic strategies that modulate redox balance to control viral replication and disease progression, this review underscores the need for mechanistic and controlled clinical studies to validate virus subfamily-tailored, redox-based antiviral approaches. Antioxid. Redox Signal. 00, 000–000.
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Assessment and reporting of nipple-areola complex sensation after reduction mammaplasty: A scoping review
(Elsevier BV, 2026-09)
Reichert, M Johow
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Urnía, N.E.
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Sanhueza, L.A.
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Turu, J
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Rimsky, P
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Robot-assisted versus conventional unicompartmental knee arthroplasty: a retrospective comparative study of postoperative complications
(Springer Science and Business Media LLC, 2026-05-25)
Gonzalez, Waldo
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Riquelme, Juan Pablo
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Arellano, Josefina
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Landea, Daniela
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FIGUEROA BERRIOS, FRANCISCO JAVIER
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Proteolytic enzymes in dentin erosion: roles of matrix metalloproteinases and cathepsins and the effectiveness of synthetic and natural inhibitors—a systematic review
(Springer Science and Business Media LLC, 2026-05-22)
Gómez, Valeria C.
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Chaple Gil, Alain
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Diaz-Dosque, Mario
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Cabello Ibacache, Rodrigo
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Fernández Godoy, Eduardo
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Measuring systemic leadership in Chilean public schools: validation of a questionnaire and its association with school outcomes
(Informa UK Limited, 2026-07-17)
ROJAS JARA, ARMANDO OCTAVIO
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Maureira Cabrera, Óscar
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Becerra Ferreira, Fernando
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Correction: Garrido et al. NGF/TRKA Decrease miR-145-5p Levels in Epithelial Ovarian Cancer Cells. Int. J. Mol. Sci. 2020, 21, 7657
(MDPI AG, 2026-06-24)
Garrido, Maritza P.
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Torres, Ignacio
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Avila, Alba
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Chnaiderman, Jonás
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Valenzuela-Valderrama, Manuel
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Comparative evaluation of the activity of novel β-lactam antibiotics against difficult-to-treat
<i>Pseudomonas aeruginosa</i>
clinical isolates
(Oxford University Press (OUP), 2026-07-02)
Mystakelis, Harry
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Shields, Ryan K
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Mathers, Amy J
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Bergman, Yehudit
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MUNITA SEPULVEDA, JOSE MANUEL
Objectives This study aimed to characterize susceptibility profiles of both currently approved and investigational β-lactam agents against difficult-to-treat resistant Pseudomonas aeruginosa (DTR P. aeruginosa) clinical isolates, including carbapenemase-producing strains. Patients and methods A total of 502 consecutive DTR P. aeruginosa clinical isolates were collected from unique hospitalized patients between 2022 and 2024 across three tertiary care centres. Isolates originated from bloodstream, respiratory, urinary and intra-abdominal infections. Minimum inhibitory concentrations (MICs) for seven β-lactam agents were determined using triplicate reference broth microdilution. Susceptibility interpretations were based on CLSI criteria or, where applicable, investigational breakpoints. Whole-genome sequencing was performed to detect β-lactamase genes. Results Among the 502 isolates, cefepime-zidebactam exhibited the highest in vitro activity (100% susceptibility), followed by cefiderocol-xeruborbactam (98%), cefiderocol (95%), ceftolozane-tazobactam (90%), cefepime-taniborbactam (86%), ceftazidime-avibactam (85%), and imipenem-relebactam (41%). Notably, only 35% of isolates were susceptible to all seven agents. Carbapenemase genes were identified in 4% of isolates, including blaGES (n = 13), blaVIM (n = 7), blaKPC (n = 1) and blaIMP (n = 1). Among carbapenemase-producing isolates, cefepime-zidebactam retained activity against all isolates (100%), exceeding that of other approved β-lactam/β-lactamase inhibitor combinations (0%–24% susceptible), cefiderocol (76%), cefiderocol-xeruborbactam (86%) and cefepime-taniborbactam (81%). Conclusions While currently approved β-lactam agents retained activity against many DTR P. aeruginosa isolates, their performance was markedly compromised in the presence of carbapenemases, with the notable exceptions of cefepime-zidebactam and cefiderocol. Investigational β-lactam/β-lactamase inhibitor combinations exhibited consistently robust activity across resistance phenotypes, including carbapenemase-producing isolates, representing promising options for DTR P. aeruginosa infections.
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Miocene bimodal magmatism in the Packsaddle Volcanic Complex, Fuegian Andes, southernmost South America: evidence of oceanic-ridge subduction
(Pontificia Universidad Catolica de Valparaiso, 2026-06-01)
Ramírez de Arellano, Cristobal
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CALDERON NETTLE, MAURICIO ROBERTO
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Aspillaga, Benjamín
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Galaz, Gonzalo
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Descote, Pierre Yves
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Protein yogurt and whey protein produce comparable muscle gains, but divergent microbiome shifts during strength training in older adults
(Springer Science and Business Media LLC, 2026-05-18)
Monsalves-Álvarez, Matías
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Calderón-Romero, Paulina
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Hayes-Ortiz, Thomas
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Bobadilla, Sofía
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Sánchez, Francisco
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Pathologic response to neoadjuvant chemotherapy in luminal breast cancer: Correlation of Residual Cancer Burden (RCB) with biological and clinical variables
(Elsevier BV, 2026-03)
Añazco Guzmán, M.I.
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Saez Moraga, N.
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Barriga Schneeberger, C.
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Pincheira Toran, P.
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Gallegos Angulo, M.

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