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Consideraciones geográficas en la interpretación de los resultados de revisiones sistemáticas y meta-análisis: fluidos en sepsis pediátrica
(2019)
Franco Díaz
;
Sebastian Gonzalez-Dambrauskas
;
Jan Hau Lee
;
Pablo Cruces
1Scopus© Citations 1
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¿Debemos utilizar las directrices de la Campaña Sobreviviendo a la Sepsis en niños con sepsis temprana? Enfoque en infusión inicial rápida de fluidos
(2019)
Franco Díaz
;
Pablo Cruces
29Scopus© Citations 2
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Driving Pressure and Normalized Energy Transmission Calculations in Mechanically Ventilated Children Without Lung Disease and Pediatric Acute Respiratory Distress Syndrome*
(2021)
Franco Díaz
;
Sebastián González-Dambrauskas
;
Federico Cristiani
;
Daniel R. Casanova
;
Pablo Cruces
Scopus© Citations 21 15
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Successful use of mild therapeutic hypothermia as compassionate treatment for severe refractory hypoxemia in COVID-19
(2021)
Pablo Cruces
;
Camila Cores
;
Daniel Casanova
;
Federico Pizarro
;
Franco Díaz
2Scopus© Citations 13
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Rationale of Therapeutic Plasma Exchange as Rescue Immunomodulatory Treatment for MIS-C With Multiorgan Failure
(2021)
Franco Díaz
;
Camila Cores
;
Omar Atenas
;
Nicolás Rodríguez
;
Raúl Bustos
3Scopus© Citations 3
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No one is better than all together: the role of networks in pediatric intensive care
(2019)
Sebastián González-Dambrauskas
;
Juan Camilo Jaramillo-Bustamante
;
Franco Díaz
1Scopus© Citations 5
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Therapeutic variability in infants admitted to Latin-American pediatric intensive units due to acute bronchiolitis
(2020)
Jesús Alberto Serra
;
Sebastián González-Dambrauskas
;
Pablo Vásquez Hoyos
;
CARVAJAL BENAVIDES, CÉSAR CRISTÓBAL
;
Alejandro Donoso
<jats:p>Objetivo: describir las terapias utilizadas en lactantes con bronquiolitis aguda admitidos en 20 Unidades de Cuidados Intensivos (UCI) pediátricos miembros de LARed en 5 países latinoamericanos.Pacientes y Método: Estudio observacional retrospectivo, multicéntrico, de datos del Registro Latinoamericano de Falla Respiratoria Aguda Pediátrica. Se incluyeron niños menores de 2 años ingresados a UCI pediátrica por bronquiolitis aguda comunitaria entre mayo-septiembre 2017. Se recolectaron datos demográficos, clínicos, soporte respiratorio, terapias utilizadas y resultados clínicos. Se realizó análisis de subgrupos según ubicación geográfica, tipo financiación y presencia de academia.Resultados: Ingresaron al registro 1.155 pacientes con falla respiratoria aguda. Seis casos fueron excluidos por no tener formulario completo. De los 1.147 pacientes, 908 eran menores de 2 años. De ellos, 467 tuvieron diagnóstico de bronquiolitis aguda, correspondiendo a la principal causa de ingreso a UCI pediátrica por falla respiratoria aguda (51,4%). Las características demográficas y de gravedad entre los centros fueron similares. El soporte máximo respiratorio más frecuente fue cánula nasal de alto flujo (47%), seguido por ventilación mecánica no invasiva (26%) y ventilación mecánica invasiva (17%), con un coeficiente de variación (CV) amplio entre los centros. Hubo una gran dispersión en uso de terapias, siendo frecuente el uso de broncodilatadores, antibióticos y corticoides, con CV hasta 400%. El análisis de subgrupos mostró diferencias significativas en soporte respiratorio y tratamientos utilizados. Un paciente falleció en esta cohorte.Conclusión: Detectamos gran variabilidad en el soporte respiratorio y tratamientos entre UCI pediátricas latinoamericanas. Esta variabilidad no es explicada por disparidades demográficas ni clínicas. Esta heterogeneidad de tratamientos debería promover iniciativas colaborativas para disminuir la brecha entre la evidencia científica y la práctica asistencial.</jats:p>
3Scopus© Citations 11
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Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2
(2020)
Raúl Bustos B
;
Juan Camilo Jaramillo-Bustamante
;
Pablo Vasquez-Hoyos
;
Pablo Cruces
;
Franco Díaz
13Scopus© Citations 24
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Latin American Consensus on the Management of Sepsis in Children: Sociedad Latinoamericana de Cuidados Intensivos Pediátricos [Latin American Pediatric Intensive Care Society] (SLACIP) Task Force: Executive Summary
(2021)
Jaime Fernández-Sarmiento
;
Daniela Carla De Souza
;
Anacaona Martinez
;
Victor Nieto
;
Jesús López-Herce
<jats:p> Objective: The aim of this study was to develop evidence-based recommendations for the diagnosis and treatment of sepsis in children in low- and middle-income countries (LMICs), more specifically in Latin America. Design: A panel was formed consisting of 27 experts with experience in the treatment of pediatric sepsis and two methodologists working in Latin American countries. The experts were organized into 10 nominal groups, each coordinated by a member. Methods: A formal consensus was formed based on the modified Delphi method, combining the opinions of nominal groups of experts with the interpretation of available scientific evidence, in a systematic process of consolidating a body of recommendations. The systematic search was performed by a specialized librarian and included specific algorithms for the Cochrane Specialized Register, PubMed, Lilacs, and Scopus, as well as for OpenGrey databases for grey literature. The GRADEpro GDT guide was used to classify each of the selected articles. Special emphasis was placed on search engines that included original research conducted in LMICs. Studies in English, Spanish, and Portuguese were covered. Through virtual meetings held between February 2020 and February 2021, the entire group of experts reviewed the recommendations and suggestions. Result: At the end of the 12 months of work, the consensus provided 62 recommendations for the diagnosis and treatment of pediatric sepsis in LMICs. Overall, 60 were strong recommendations, although 56 of these had a low level of evidence. Conclusions: These are the first consensus recommendations for the diagnosis and management of pediatric sepsis focused on LMICs, more specifically in Latin American countries. The consensus shows that, in these regions, where the burden of pediatric sepsis is greater than in high-income countries, there is little high-level evidence. Despite the limitations, this consensus is an important step forward for the diagnosis and treatment of pediatric sepsis in Latin America. </jats:p>
8Scopus© Citations 32
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A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
(2020)
Pablo Cruces
;
Jaime Retamal
;
Daniel E. Hurtado
;
Benjamín Erranz
;
Pablo Iturrieta
<jats:title>Abstract</jats:title><jats:p>Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.</jats:p><jats:p>In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.</jats:p>
8Scopus© Citations 103

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