A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection
Journal
Critical Care
ISSN
1364-8535
Date Issued
2020
Author(s)
Pablo Cruces
Jaime Retamal
Daniel E. Hurtado
Benjamín Erranz
Pablo Iturrieta
Carlos González
Franco Díaz
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:p>Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.</jats:p><jats:p>In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.</jats:p>
Cite this document
Cruces, P., Retamal, J., Hurtado, D. E., Erranz, B., Iturrieta, P., González, C., & Díaz, F. (2020). A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection. Critical Care, 24(1), 494. https://doi.org/10.1186/s13054-020-03197-7
Subjects
covid-19
;
lung strain
;
mechanical ventilation
;
p-sili
;
sars-cov2
;
work of breathing
;
coronavirus infections
;
critical care
;
disease progression
;
humans
;
lung injury
;
pandemics
;
pneumonia, viral
;
randomized controlled trials as topic
;
respiration, artificial
;
work of breathing
;
acute respiratory failure
;
biochemical analysis
;
breathing
;
coronavirus disease 2019
;
disease association
;
disease duration
;
disease exacerbation
;
disease severity
;
human
;
lung injury
;
mechanotransduction
;
mortality rate
;
positive pressure ventilation
;
priority journal
;
review
;
risk factor
;
artificial ventilation
;
coronavirus infection
;
disease exacerbation
;
intensive care
;
lung injury
;
pandemic
;
pathophysiology
;
physiology
;
randomized controlled trial (topic)
;
virus pneumonia
;
work of breathing