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The landscape of dementia research, diagnosis, treatment, and care in Latin America
(Wiley, 2026-03)
Claudia K. Suemoto
;
Nilton Custodio
;
Diego Aguilar
;
José A. Avila‐Funes
;
Sandra Baez
<jats:title>Abstract</jats:title> <jats:sec> <jats:label/> <jats:p>Latin America is undergoing rapid population aging alongside a rising burden of dementia. While the region holds substantial potential for dementia risk reduction, challenges remain, such as delayed diagnoses, limited access to specialized care and biomarker testing, persistent stigma, and deep‐rooted structural inequities. To address these gaps and foster regionally informed solutions, the Alzheimer's Association convened the 2025 Alzheimer's Association International Conference (AAIC) Satellite Symposium in Lima, Peru, on May 14–15, in collaboration with the Global Brain Health Institute (GBHI) and the Atlantic Fellows for Equity in Brain Health. The meeting aimed to bring core elements of the global AAIC meeting to regional Latin American settings, recognizing that national and cultural contexts demand tailored approaches to dementia prevention, risk reduction, treatment and care all aimed at promoting brain health in the region. This manuscript synthesizes the symposium's key discussions, scientific advances, and opportunities for collaboration across the region.</jats:p> </jats:sec>
1Scopus© Citations 1
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Peruvian validation and standardization of the TabCAT-brain health assessment
(Frontiers Media SA, 2025-08-29)
Andrés Muñoz-Najar
;
Manuel Montemurro
;
María del Carmen Tejada
;
Claudia Rivera-Fernández
;
Miguel Sánchez-Fernández
Introduction. Detecting cognitive impairment in low-educated and marginalized populations may result in under- or over-estimation of diagnoses due to reliance on non-validated approaches and normative data. This study validates and standardizes TabCAT-BHA for older adults living in the Andean region of Peru using regression-based normalization.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Two hundred fifty-eight participants were assessed with the MMSE, RUDAS, and TabCAT-BHA. Classified as either cognitively healthy or impaired based on Clinical Dementia Rating criteria.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>By incorporating sex, place of residence, age, and years of education as covariates, the TabCAT-BHA demonstrated greater accuracy in detecting cognitive impairment (AUC = 75.3%) compared to the MMSE (AUC = 66.4%) and RUDAS (AUC = 71.4%). After incorporating only significant sociodemographic predictors, TabCAT-BHA obtained better AUC (77.4%) compared to MMSE (66.6%) and RUDAS (71.9%).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>The TabCAT-BHA proves to be a valid tool for detecting cognitive impairment, and incorporating sociodemographic factors improves its accuracy in marginalized settings of Peru.
Scopus© Citations 1 1
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Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research
(2024)
Karen Nuytemans
;
Sanne Franzen
;
Iris J. Broce
;
Paulo Caramelli
;
Ratnavalli Ellajosyula
<jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of young‐onset dementia before age 65, typically manifesting as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). Although FTD affects all populations across the globe, knowledge regarding the pathophysiology and genetics derives primarily from studies conducted in North America and Western Europe. Globally, biomedical research for FTD is hindered by variable access to diagnosis, discussed in this group's earlier article, and by reduced access to expertise, funding, and infrastructure. This perspective paper was produced by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) and discusses the field's current status on the cross‐cultural aspects of basic and translational research in FTD (including that focused on epidemiology, genetics, biomarkers, and treatment). It subsequently provides a summary of gaps and needs to address the disparities and advance global FTD biomedical research.</jats:p>
Scopus© Citations 4
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Assessing processing speed and its neural correlates in the three variants of primary progressive aphasia with a non-verbal tablet-based task
(2024)
GAJARDO VIDAL, ANDREA ELIZABETH
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Maxime Montembeault
;
Diego L. Lorca-Puls
;
Abigail E. Licata
;
Rian Bogley
Scopus© Citations 4 1
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Gaps in clinical research in frontotemporal dementia: A call for diversity and disparities–focused research
(2023)
Sanne Franzen
;
Karen Nuytemans
;
Renelle Bourdage
;
Paulo Caramelli
;
Ratnavalli Ellajosyula
<jats:title>Abstract</jats:title><jats:p>Frontotemporal dementia (FTD) is one of the leading causes of dementia before age 65 and often manifests as abnormal behavior (in behavioral variant FTD) or language impairment (in primary progressive aphasia). FTD's exact clinical presentation varies by culture, language, education, social norms, and other socioeconomic factors; current research and clinical practice, however, is mainly based on studies conducted in North America and Western Europe. Changes in diagnostic criteria and procedures as well as new or adapted cognitive tests are likely needed to take into consideration global diversity. This perspective paper by two professional interest areas of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment examines how increasing global diversity impacts the clinical presentation, screening, assessment, and diagnosis of FTD and its treatment and care. It subsequently provides recommendations to address immediate needs to advance global FTD research and clinical practice.</jats:p>
27Scopus© Citations 12

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