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Item type:Publication, A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection(2020) ;Pablo Cruces ;Jaime Retamal ;Daniel E. Hurtado ;Benjamín ErranzPablo Iturrieta<jats:title>Abstract</jats:title><jats:p>Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.</jats:p><jats:p>In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.</jats:p>8Scopus© Citations 103 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Connexinopathies: a structural and functional glimpse(2016) ;Isaac E. García ;Pavel Prado ;Amaury Pupo ;Oscar JaraDiana Rojas-Gómez12 1Scopus© Citations 44 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Carbon monoxide: A new player in the redox regulation of connexin hemichannels(2015); ;Carmen G. León-Paravic; ;Rodrigo Del RioScopus© Citations 15 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins(2016) ;Bernardo I. Pinto ;Isaac E. García ;Amaury Pupo; Agustín D. Martínez2Scopus© Citations 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extracellular Cysteine in Connexins: Role as Redox Sensors(2016); ;Isaac E. García ;Bernardo I. Pinto ;Amaury PupoDavid BáezScopus© Citations 30 1