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Item type:Publication, Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security(Elsevier BV, 2025-03) ;Hamish R Graham ;Carina King ;Ahmed Ehsanur Rahman ;Freddy Eric KitutuLeith GreensladeScopus© Citations 53 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The Persistence of Biologic Therapies for Psoriatic Arthritis(2024) ;Magdalena Jasmen ;Dominga García; Pamela Díaz<jats:title>Abstract</jats:title> <jats:p>Drug persistence is a crucial measure of long-term efficacy, safety, and patient satisfaction. Lack of persistence can increase healthcare costs and morbidity and mortality rates. This review aimed to consolidate available data on drug persistence for various biological treatments used as the primary intervention for psoriatic arthritis and identify factors associated with nonpersistence. Reports indicate variable 1-year persistence rates for biologic therapies, ranging from 37% to 73%. Specifically, tumor necrosis factor inhibitors have shown fluctuating 1-year persistence rates ranging from 32% to 85%. IL-12/23 and IL-23 inhibitors demonstrate persistence rates of 25% to 89%, whereas data for IL-17 and JAK inhibitors are more limited, ranging from 51% to 77%. Factors such as female sex and a higher burden of comorbidities have been associated with an increased risk of nonpersistence, although evidence regarding other factors remains scarce. The significant variability in reported persistence rates may be attributed to differences in treatment gaps and methodologies across studies. Addressing and mitigating the factors leading to nonpersistence is essential for improving treatment outcomes in psoriatic arthritis.</jats:p>Scopus© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Recuperación mejorada después de cirugía torácica. ERAS(2019) ;MARCELO FELIPE PARRA NOVOA ;LORENA CÁCERES M. ;JOSÉ ORTEGA S. ;BERNARDITA VALENZUELA M.FRANCISCO JOFRÉ C.Scopus© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Minimally Invasive Surgery for Traumatic Thoracolumbar Fractures: A Cross-Sectional Study of Spine Surgeons(2023) ;Guillermo A. Ricciardi ;Juan Ignacio Cirillo Totera ;Juan P. Cabrera ;Alfredo GuiroyCharles A. Carazzo7Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lives lost and disease burden related to antimicrobial resistance in the Americas can no longer be ignored(2023) ;Eduardo A. Undurraga ;Anne Peters ;Cesar A. Arias2Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Pharmacogenetics in Psychiatry: Perceived Value and Opinions in a Chilean Sample of Practitioners(2021); ;Ignacio Bórquez-Infante ;Nicolás A. Crossley ;Miguel L. Prieto<jats:p>Use of pharmacogenetics (PGx) testing to guide clinical decisions is growing in developed countries. Published guidelines for gene–drug pair analysis are available for prescriptions in psychiatry, but information on their utilization, barriers, and health outcomes in Latin America is limited. As a result, this work aimed at exploring current use, opinions, and perceived obstacles on PGx testing among psychiatrists in Chile, via an online, anonymous survey. Among 123 respondents (5.9% of registered psychiatrists in the country), 16.3% reported ever requesting a PGx test. The vast majority (95%) of tests were ordered by clinicians practicing in the Metropolitan Region of Santiago. Having more than 20 years in practice was positively associated with prior use of PGx (p 0.02, OR 3.74 (1.19–11.80)), while working in the public health system was negatively associated (OR 0.30 (0.10–0.83)). Perceived barriers to local implementation included insufficient evidence of clinical utility, limited clinicians’ knowledge on PGx and on test availability, and health systems’ issues, such as costs and reimbursement. Despite the recognition of these barriers, 80% of respondents asserted that it is likely that they will incorporate PGx tests in their practice in the next five years. Given these results, we propose next steps to facilitate implementation such as further research in health outcomes and clinical utility of known and novel clinically actionable variants, growth in local sequencing capabilities, education of clinicians, incorporation of clinical decision support tools, and economic evaluations, all in local context.</jats:p>1Scopus© Citations 10 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Dementia in Latin America: Paving the way toward a regional action plan(2020) ;Mario Alfredo Parra ;Sandra Baez ;Lucas Sedeño ;Cecilia Gonzalez CampoHernando Santamaría‐García2Scopus© Citations 115 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effectiveness of homologous and heterologous booster doses for an inactivated SARS-CoV-2 vaccine: a large-scale prospective cohort study(2022) ;Alejandro Jara ;Eduardo A Undurraga ;José R Zubizarreta ;Cecilia GonzálezAlejandra PizarroScopus© Citations 158 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, “If I get sick here, I will never see my children again”: The mental health of international migrants during the COVID-19 pandemic in Chile(2022) ;Alice Blukacz; ;Kate E. Pickett; Paula Madrid<jats:sec id="sec001"> <jats:title>Background</jats:title> <jats:p>The COVID-19 pandemic has had an impact on the mental health of international migrants globally. Chile has managed its response to the pandemic in an ongoing context of social unrest and combined regional migratory and humanitarian crisis. The country’s population presents a high prevalence of common mental disorders and a high suicide rate, with limited access to mental healthcare. International migrants in Chile represent 8% of the total population, and although a socioeconomically heterogenous group, they face social vulnerability, a range of mental health stressors and additional barriers to access mental healthcare. This study describes the mental health outcomes, stressors, response, and coping strategies perceived by international migrants during the COVID-19 pandemic in Chile.</jats:p> </jats:sec> <jats:sec id="sec002"> <jats:title>Methods and findings</jats:title> <jats:p>A qualitative case study was carried out through individual online interviews to 30 international migrants living in Chile during the pandemic and 10 experts of the social and health care sectors. An inductive content analysis was carried out, a process during which the researchers sought to identify patterns and themes derived from the data. Participants experienced mainly negative mental health outcomes, including anxiety and depression symptomatology. Stressors included the virus itself, work, living and socioeconomic conditions, discrimination, fear for their family and distance caring. Institutional responses to address the mental health of international migrants during the pandemic in Chile were limited and participants relied mainly on individual coping strategies.</jats:p> </jats:sec> <jats:sec id="sec003"> <jats:title>Conclusions</jats:title> <jats:p>The pandemic can represent an important opportunity to strengthen mental health systems for the general population as well as for population groups experiencing social vulnerability, if the issues identified and the lessons learned are translated into action at national, regional, and international level. Promoting the mental health of international migrants means recognising migration as a social determinant of mental health and adopting a cross-cultural as well as a Human Rights approach.</jats:p> </jats:sec>Scopus© Citations 4 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The impact of hypoglycemia on healthcare costs: a modeling study from Chile(2020) ;Carlos Balmaceda ;Manuel A. Espinoza; Nazareth EspinozaScopus© Citations 1 1