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Psychiatric genetics in the diverse landscape of Latin American populations
(Springer Science and Business Media LLC, 2025-04-02)
Estela M. Bruxel
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Diego L. Rovaris
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Sintia I. Belangero
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Gabriela Chavarría-Soley
;
Alfredo B. Cuellar-Barboza
4
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Brain Network Architecture Intricately Linked to Morphological Abnormalities in Major Psychiatric Disorders
(2021)
Foivos Georgiadis
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Lariviere, Sara
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Vaughan Carr
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Stanley Catts
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Green, Melissa
1
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Los costos y consumo de recursos sanitarios asociados a episodios maníacos en la práctica clínica diaria: el estudio MANACOR
(2015)
Diego Hidalgo-Mazzei
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UNDURRAGA FOURCADE, JUAN PABLO
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María Reinares
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Caterina del Mar Bonnín
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Cristina Sáez
6Scopus© Citations 16
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Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder
(2017-12-01)
ZAMORANO MENDIETA, FRANCISCO JAVIER
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BILLEKE BOBADILLA, PABLO ERNESTO
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Kausel, Leonie
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Larrain, Josefina
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STECHER GUZMAN, XIMENA PATRICIA
Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a "congruent condition" and an "incongruent condition". The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -A greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT.
3Scopus© Citations 15
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Clinicians’ preferences and attitudes towards the use of lithium in the maintenance treatment of bipolar disorders around the world: a survey from the ISBD Lithium task force
(2023-12-01)
Hidalgo-Mazzei, Diego
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Mantingh, Tim
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Pérez de Mendiola, Xavier
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Samalin, Ludovic
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UNDURRAGA FOURCADE, JUAN PABLO
Background: Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a steady decline in lithium prescriptions during the last two decades. We aim to identify potential factors explaining this decline across the world with an anonymous worldwide survey developed by theInternational Society for Bipolar Disorders (ISBD) Task Force “Role of Lithium in Bipolar Disorders” anddistributed by diverse academic and professional international channels. Results: A total of 886 responses were received of which 606 completed the entirequestionnaire while 206 completed it partially. Respondents were from 43 different countries comprising allcontinents. Lithium was the most preferred treatment option for the maintenance of BD patients (59%). The mostrelevant clinical circumstances in which lithium was the preferred option were in patients with BD I (53%), afamily history of response (18%), and a prior response during acute treatment (17%). In contrast, Lithium wasnot the preferred option in case of patients´ negative beliefs and/or attitudes towards lithium (13%), acuteside-effects or tolerability problems (10%) and intoxication risk (8%). Clinicians were less likely to preferlithium as a first option in BD maintenance phase when practising in developing economy countries [X2 (1,N = 430) = 9465, p = 0.002)] and private sectors [X2 (1, N = 434) = 8191, p = 0.004)]. Conclusions: Clinicians’ preferences and attitudes towards the use of lithium in the maintenancetreatment of bipolar disorders appear to be affected by both the patients’ beliefs and the professionalcontexts where clinicians provide their services. More research involving patients is needed for identifyingtheir attitudes toward lithium and factors affecting its use, particularly in developing economies.
Scopus© Citations 28 1
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Prodromal phase: Differences in prodromal symptoms, risk factors and markers of vulnerability in first episode mania versus first episode psychosis with onset in late adolescence or adulthood
(2022)
Norma Verdolini
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Roger Borràs
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Giulio Sparacino
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Marina Garriga
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Maria Sagué‐Vilavella
Scopus© Citations 9 2
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Shaped before birth: Obstetric complications identify a more severe clinical phenotype among patients presenting a first affective or non-affective episode of psychosis
(2022)
Maria Sagué-Vilavella
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Silvia Amoretti
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Marina Garriga
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Gisela Mezquida
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Evelyn Williams
1Scopus© Citations 10 1
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Differences of affective and non-affective psychoses in early intervention services from Latin America
(2022)
Raphael O. Cerqueira
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Carolina Ziebold
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Daniel Cavalcante
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Giovany Oliveira
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Javiera Vásquez
Scopus© Citations 8 8
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Mapping Subcortical Brain Alterations in 22q11.2 Deletion Syndrome: Effects of Deletion Size and Convergence With Idiopathic Neuropsychiatric Illness
(2020)
Christopher R.K. Ching
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Boris A. Gutman
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Daqiang Sun
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Julio Villalon Reina
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Anjanibhargavi Ragothaman
Scopus© Citations 44 8
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Emotional intelligence: a comparison between patients after first episode mania and those suffering from chronic bipolar disorder type I
(2022)
Cristina Varo
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Silvia Amoretti
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Giulio Sparacino
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Esther Jiménez
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Brisa Solé
<jats:title>Abstract</jats:title> <jats:sec id="S0033291721005122_sec_a1"> <jats:title>Background</jats:title> <jats:p>Deficits in emotional intelligence (EI) were detected in patients with bipolar disorder (BD), but little is known about whether these deficits are already present in patients after presenting a first episode mania (FEM). We sought (i) to compare EI in patients after a FEM, chronic BD and healthy controls (HC); (ii) to examine the effect exerted on EI by socio-demographic, clinical and neurocognitive variables in FEM patients.</jats:p> </jats:sec> <jats:sec id="S0033291721005122_sec_a2" sec-type="methods"> <jats:title>Methods</jats:title> <jats:p>The Emotional Intelligence Quotient (EIQ) was calculated with the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT). Performance on MSCEIT was compared among the three groups using generalized linear models. In patients after a FEM, the influence of socio-demographic, clinical and neurocognitive variables on the EIQ was examined using a linear regression model.</jats:p> </jats:sec> <jats:sec id="S0033291721005122_sec_a3" sec-type="results"> <jats:title>Results</jats:title> <jats:p>In total, 184 subjects were included (FEM <jats:italic>n</jats:italic> = 48, euthymic chronic BD type I <jats:italic>n</jats:italic> = 75, HC <jats:italic>n</jats:italic> = 61). BD patients performed significantly worse than HC on the EIQ [mean difference (MD) = 10.09, standard error (<jats:sc>s.e.)</jats:sc> = 3.14, <jats:italic>p</jats:italic> = 0.004] and on the understanding emotions branch (MD = 7.46, <jats:sc>s.e.</jats:sc> = 2.53, <jats:italic>p</jats:italic> = 0.010). FEM patients did not differ from HC and BD on other measures of MSCEIT. In patients after a FEM, EIQ was positively associated with female sex (<jats:italic>β</jats:italic> = −0.293, <jats:italic>p</jats:italic> = 0.034) and verbal memory performance (<jats:italic>β</jats:italic> = 0.374, <jats:italic>p</jats:italic> = 0.008). FEM patients performed worse than HC but better than BD on few neurocognitive domains.</jats:p> </jats:sec> <jats:sec id="S0033291721005122_sec_a4" sec-type="conclusions"> <jats:title>Conclusions</jats:title> <jats:p>Patients after a FEM showed preserved EI, while patients in later stages of BD presented lower EIQ, suggesting that impairments in EI might result from the burden of disease and neurocognitive decline, associated with the chronicity of the illness.</jats:p> </jats:sec>
Scopus© Citations 4 2

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