Network anatomy in logopenic variant of primary progressive aphasia
Journal
Human Brain Mapping
ISSN
1065-9471
Date Issued
2023
Author(s)
Maria Luisa Mandelli
Diego L. Lorca‐Puls
Sladjana Lukic
Maxime Montembeault
Abigail Licata
Aaron Scheffler
Giovanni Battistella
Stephanie M. Grasso
Rian Bogley
Buddhika M. Ratnasiri
Renaud La Joie
Nidhi S. Mundada
Eduardo Europa
Gil Rabinovici
Bruce L. Miller
Jessica De Leon
Maya L. Henry
Zachary Miller
Maria Luisa Gorno‐Tempini
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:title>Abstract</jats:title><jats:p>The logopenic variant of primary progressive aphasia (lvPPA) is a neurodegenerative syndrome characterized linguistically by gradual loss of repetition and naming skills resulting from left posterior temporal and inferior parietal atrophy. Here, we sought to identify which specific cortical loci are initially targeted by the disease (epicenters) and investigate whether atrophy spreads through predetermined networks. First, we used cross‐sectional structural MRI data from individuals with lvPPA to define putative disease epicenters using a surface‐based approach paired with an anatomically fine‐grained parcellation of the cortical surface (i.e., HCP‐MMP1.0 atlas). Second, we combined cross‐sectional functional MRI data from healthy controls and longitudinal structural MRI data from individuals with lvPPA to derive the epicenter‐seeded resting‐state networks most relevant to lvPPA symptomatology and ascertain whether functional connectivity in these networks predicts longitudinal atrophy spread in lvPPA. Our results show that two partially distinct brain networks anchored to the left anterior angular and posterior superior temporal gyri epicenters were preferentially associated with sentence repetition and naming skills in lvPPA. Critically, the strength of connectivity within these two networks in the neurologically‐intact brain significantly predicted longitudinal atrophy progression in lvPPA. Taken together, our findings indicate that atrophy progression in lvPPA, starting from inferior parietal and temporoparietal junction regions, predominantly follows at least two partially nonoverlapping pathways, which may influence the heterogeneity in clinical presentation and prognosis.</jats:p>
Subjects
alzheimer's disease
;
cortical atrophy
;
intrinsic connectivity networks
;
logopenic variant
;
longitudinal study
;
primary progressive aphasia
;
alzheimer disease
;
aphasia, primary progressive
;
atrophy
;
brain
;
cross-sectional studies
;
humans
;
neuropsychological tests
;
biological marker
;
pittsburgh compound b
;
adult
;
age
;
alzheimer disease
;
anatomical location
;
article
;
autopsy
;
california verbal learning test
;
clinical feature
;
clinical observation
;
comprehension
;
controlled study
;
cortical thickness (brain)
;
cross-sectional study
;
demographics
;
dorsolateral prefrontal cortex
;
educational status
;
episodic memory
;
female
;
functional connectivity strength
;
gray matter
;
handedness
;
human
;
human tissue
;
image processing
;
independent component analysis
;
intrinsic connectivity network
;
kernel method
;
logopenic variant primary progressive aphasia
;
low-dose computed tomography
;
major clinical study
;
male
;
mini mental state examination
;
nerve cell network
;
neuroimaging
;
neuropathology
;
neuropsychological assessment
;
nuclear magnetic resonance imaging
;
ordered subset expectation maximization
;
peabody picture vocabulary test
;
positron emission tomography
;
posterior cingulate
;
prediction
;
primary progressive aphasia
;
quantitative analysis
;
resting state network
;
salience network
;
sex
;
short term memory
;
standardized uptake value ratio
;
superior temporal gyrus
;
surface property
;
temporal cortex
;
temporoparietal junction
;
western aphasia battery
;
alzheimer disease
;
atrophy
;
brain
;
diagnostic imaging
;
pathology
;
primary progressive aphasia