Pharmacogenetics in Psychiatry: Perceived Value and Opinions in a Chilean Sample of Practitioners
Journal
Frontiers in Pharmacology
ISSN
1663-9812
Date Issued
2021
Author(s)
Ignacio Bórquez-Infante
Nicolás A. Crossley
Miguel L. Prieto
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Use of pharmacogenetics (PGx) testing to guide clinical decisions is growing in developed countries. Published guidelines for gene–drug pair analysis are available for prescriptions in psychiatry, but information on their utilization, barriers, and health outcomes in Latin America is limited. As a result, this work aimed at exploring current use, opinions, and perceived obstacles on PGx testing among psychiatrists in Chile, via an online, anonymous survey. Among 123 respondents (5.9% of registered psychiatrists in the country), 16.3% reported ever requesting a PGx test. The vast majority (95%) of tests were ordered by clinicians practicing in the Metropolitan Region of Santiago. Having more than 20 years in practice was positively associated with prior use of PGx (p 0.02, OR 3.74 (1.19–11.80)), while working in the public health system was negatively associated (OR 0.30 (0.10–0.83)). Perceived barriers to local implementation included insufficient evidence of clinical utility, limited clinicians’ knowledge on PGx and on test availability, and health systems’ issues, such as costs and reimbursement. Despite the recognition of these barriers, 80% of respondents asserted that it is likely that they will incorporate PGx tests in their practice in the next five years. Given these results, we propose next steps to facilitate implementation such as further research in health outcomes and clinical utility of known and novel clinically actionable variants, growth in local sequencing capabilities, education of clinicians, incorporation of clinical decision support tools, and economic evaluations, all in local context.</jats:p>
Cite this document
Undurraga, J., Bórquez-Infante, I., Crossley, N. A., Prieto, M. L., & Repetto, G. M. (2021). Pharmacogenetics in psychiatry: Perceived value and opinions in a chilean sample of practitioners. Frontiers in Pharmacology, 12, 657985. https://doi.org/10.3389/fphar.2021.657985
Subjects
pharmacogenetics
;
psychiatry
;
implementation
;
chile
;
latin america
;
article
;
chilean
;
clinical decision support system
;
clinical practice
;
economic evaluation
;
health care cost
;
health care system
;
human
;
pharmacogenetic testing
;
pharmacogenetics
;
professional knowledge
;
psychiatrist
;
psychiatry
;
public health
;
reimbursement