BEHRENS PELLEGRINO, MARIA ISABEL

Preferred name
BEHRENS PELLEGRINO, MARIA ISABEL
Official Name
BEHRENS PELLEGRINO, MARIA ISABEL
Main Affiliation
Email
mbehrens@udd.cl
ORCID
0000-0003-0964-426X
Scopus Author ID
7007110355
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    Route efficiency in spatial navigation as an early indicator of cognitive decline in amnestic mild cognitive impairment
    (Frontiers Media SA, 2026-05-08)
    Nicole Rogers
    ;
    Carol Dazil SanMartín
    ;
    Jamileth More
    ;
    César Romero
    ;
    Daniela Paz Ponce
    <jats:sec> <jats:title>Introduction</jats:title> <jats:p>The hippocampus is one of the brain regions most affected by neurodegeneration in Alzheimer’s disease (AD). This structure and its neural circuits are critically involved in spatial learning and memory. Poor spatial navigation performance in virtual environments such as the Virtual Morris Water Navigation Task (VMWNT) may precede other clinical findings in amnestic mild cognitive impairment (aMCI), a pre-dementia stage of AD. To explore this idea, we correlated aMCI and cognitively healthy control (HC) performance in the VMWNT with Montreal Cognitive Assessment (MoCA) and Memory Index Score (MoCA-MIS), testing whether navigation-derived metrics are associated with cognitive performance within a framework of shared medial temporal lobe vulnerability.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Thirty-eight participants (18 aMCI, 20 HC) were assessed for neurologic evaluation and VMWNT performance. Neuropsychological tests, including MoCA, MoCA-MIS, Clinical Dementia Rating (CDR), CDR sum of boxes (CDR-SOB) and AD8, were performed. Group differences were assessed using Mann–Whitney U tests on participant-level means and complemented with mixed-effects models to account for the repeated-measures structure of trial-level data. All behavioral parameters obtained in the VMWNT were reduced to a single variable, “Route Efficiency,” through Principal Component Analysis (PCA) on five navigation variables, with the aim to correlate spatial memory performance with clinical findings.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p> Significant differences in VMWNT performance were observed. aMCI patients displayed longer path lengths ( <jats:italic>p</jats:italic> = 0.006), more quadrant crossings ( <jats:italic>p</jats:italic> = 0.010), reduced time in target quadrant ( <jats:italic>p</jats:italic> &amp;lt; 0.001), and fewer target crossings ( <jats:italic>p</jats:italic> = 0.006), with group differences most evident in Stage 2; Stage 3 showed no significant differences for most variables. Route Efficiency was significantly lower in aMCI than HC ( <jats:italic>p</jats:italic> &amp;lt; 0.001); correlations with MoCA and MoCA-MIS were observed across the full sample but were nonsignificant within groups. Stage 3 allocentric navigation did not reveal consistent group differences. Using nested cross-validation, the AUC for aMCI detection was 0.78 (95% CI: 0.63–0.91). </jats:p> </jats:sec> <jats:sec> <jats:title>Discussion</jats:title> <jats:p>Group differences in Route Efficiency and correlations with cognitive measures were observed, though these associations primarily reflected between-group rather than individual variation. Allocentric significant findings were not observed. These preliminary results support further exploration of virtual navigation paradigms in clinical settings.</jats:p> </jats:sec>
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    1278 Feasibility of 48-h Ambulatory BP Assessment in Latinos with Dementia
    (Oxford University Press (OUP), 2025-05)
    Mili Jimenez Gallardo
    ;
    Andrea Castillo Suárez
    ;
    Peng Li
    ;
    Ramon C Hermida
    ;
    Michael Smolensky
    Abstract Introduction Ambulatory blood pressure (BP) monitoring encapsulates 24-h BP patterns across the sleep-wake cycle and provides a comprehensive assessment of BP regulation with certain features, such as sleep-time dipping, that can better predict health outcomes than traditional office BP measurements. However, 24-h BP patterns remain understudied in Latino populations, especially older adults. This pilot study investigated the feasibility of continuously ambulatory BP monitoring blood pressure with portable devices in Latinos with dementia. Methods Eight participants (4 with Alzheimer’s disease, 1 with Frontotemporal dementia, 3 controls; age range 45.8-80.3 years) from the ReDLat cohort (Multi-Partner Consortium to Expand Dementia Research in Latin America) were enrolled for a 48-h ambulatory BP assessment with hourly measurements using a portable arm-cuff device. Participants also answered six questions to evaluate: (1) device adaption, (2) measurement frequency tolerability, (3) study duration acceptability, (4) perceived value of the assessment, (5) willingness to perform the assessment again, and (6) likelihood of recommending the assessment to others. Results The study yielded high-quality recordings with minimal missing BP measurements (range: 0%-14.1%; mean: 8.9%). Device adaptation improved over time, with 75% (6/8) reporting better tolerance on the second day and 25% (2/8) reporting consistently good tolerance across both days. All participants reported that hourly BP measurement was tolerable, and majority (7/8, 87.5%) found 48-h monitoring acceptable. Seven participants (87.5%) believed that the assessment was valuable, were willing to participate again, and likely recommend to others the assessment. Conclusion Our findings demonstrate that 48-hour ambulatory BP monitoring is feasible and well-tolerated among older Latino adults with mild to moderate dementia in Latin American settings. Further feasibility testing should be performed in large samples and other populations, including individuals at later stages of dementia and in different countries.
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    Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity
    (2014-03)
    Ponce, Daniela
    ;
    Salech, Felipe
    ;
    Sanmartin, Carol
    ;
    Silva, Mónica
    ;
    Xiong, Chengjie
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    The Impact of a Yoga-Based Mindfulness Intervention versus Psycho-Educational Session for Older Adults with Mild Cognitive Impairment: The Protocol of a Randomized Controlled Trial
    (2022)
    Maryam Farhang
    ;
    Graciela Rojas
    ;
    Pablo Martínez
    ;
    BEHRENS PELLEGRINO, MARIA ISABEL  
    ;
    Álvaro I. Langer
    <jats:p>Background: There is a global agreement in the medical community that a significant proportion of dementia cases could be prevented or postponed. One of the factors behind this agreement comes from scientific evidence showing that mind-body interventions such as mindfulness and yoga for the elderly have been related to a range of positive outcomes, including improved cognition performance in seniors with mild cognitive impairment (MCI). Objective: This study aims to evaluate the effectiveness of a yoga-based mindfulness intervention (YBM) versus psychoeducational sessions for older adults with MCI attending Hospital Clinic Universidad de Chile in Santiago. Method: Two-arm, individually randomized controlled trial (RCT) will be carried out at Clinical Hospital Universidad de Chile in Santiago. Older people over 60 years with any type of MCI using a score &lt; 21 in the Montreal Cognitive Assessment (MoCA) test and a score of 0.05 in the Clinical Dementia Rating (CDR) Scale; and with preserved activities of daily living will be randomly assigned with an allocation ratio of 1:1 in either the yoga-based mindfulness intervention or the active control group based on the psycho-educational program. People who have performed yoga and/or mindfulness in the last 6 months or/and people with a psychiatric clinical diagnosis will be excluded from the study. Montreal Cognitive Assessment, the Lawton Instrumental Activities of Daily Living Scale (IADL), the Barthel Index (BI), the Pemberton happiness index, the Geriatric Anxiety Inventory (GAI) as well as the Geriatric Depression Scale (GDS-5) will be administered by blinded outcomes assessors before random assignment (Pre-test), the week following the last session of the intervention (post-test), and then after 3- and 6-months follow-up. Results: The YBM intervention protocol based on a video recording has been adapted and designed. This is the first RCT to examine the effects of a yoga-based mindfulness intervention in improving cognitive and physical functions and mental health outcomes for Chilean elderly diagnosed with MCI. It is expected to be implemented as an acceptable and effective non-pharmacological option for older people with MCI. Conclusion: Providing evidence-based programs such as preventive therapy for Alzheimer’s disease has relevant implications for public mental health services in Chile.</jats:p>
    Scopus© Citations 7  1
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    PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients
    (2017)
    Salech, Felipe
    ;
    Ponce, Daniela
    ;
    SanMartín, Carol
    ;
    Nicole K. Rogers
    ;
    Carlos Chacón
      6Scopus© Citations 25