The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science
Journal
Frontiers in Neurology
ISSN
1664-2295
Date Issued
2021
Author(s)
Agustin Ibanez
Jennifer S. Yokoyama
Katherine L. Possin
Diana Matallana
Francisco Lopera
Ricardo Nitrini
Leonel T. Takada
Nilton Custodio
Ana Luisa Sosa Ortiz
José Alberto Avila-Funes
Richard M. Myers
J. Nicholas Cochran
Luis Ignacio Brusco
Martin A. Bruno
Sonia M. D. Brucki
Stefanie Danielle Pina-Escudero
Maira Okada de Oliveira
Patricio Donnelly Kehoe
Adolfo M. Garcia
Juan Felipe Cardona
Hernando Santamaria-Garcia
Sebastian Moguilner
Claudia Duran-Aniotz
Enzo Tagliazucchi
Marcelo Maito
Erika Mariana Longoria Ibarrola
Maritza Pintado-Caipa
Maria Eugenia Godoy
Vera Bakman
Shireen Javandel
Kenneth S. Kosik
Victor Valcour
Bruce L. Miller
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.</jats:p>
Subjects
dementia
;
fronto-temporal dementia
;
ses
;
sdoh
;
genetics
;
alzheimer&apos
;
s disease
;
implementation science
;
latin america
;
algorithm
;
alzheimer disease
;
clinical practice
;
cognition assessment
;
deep learning
;
dementia
;
frontotemporal dementia
;
gene mutation
;
genetic heterogeneity
;
genotype environment interaction
;
heredity
;
human
;
medical education
;
medical research
;
neuroimaging
;
prevalence
;
review
;
risk assessment
;
risk factor
;
social aspect
;
social cognition
;
socioeconomics
;
south and central america
;
translational research