BEHRENS PELLEGRINO, MARIA ISABEL

Preferred name
BEHRENS PELLEGRINO, MARIA ISABEL
Official Name
BEHRENS PELLEGRINO, MARIA ISABEL
Main Affiliation
Email
mbehrens@udd.cl
ORCID
0000-0003-0964-426X
Scopus Author ID
7007110355
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    The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science
    (2021)
    Agustin Ibanez
    ;
    Jennifer S. Yokoyama
    ;
    Katherine L. Possin
    ;
    Diana Matallana
    ;
    Francisco Lopera
    <jats:p>Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.</jats:p>
      9Scopus© Citations 99
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    Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity
    (2014-03)
    Ponce, Daniela
    ;
    Salech, Felipe
    ;
    Sanmartin, Carol
    ;
    Silva, Mónica
    ;
    Xiong, Chengjie
      3
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    Author Correction: The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds
    (2024)
    Pavel Prado
    ;
    Vicente Medel
    ;
    Raul Gonzalez-Gomez
    ;
    Agustín Sainz-Ballesteros
    ;
    Victor Vidal
      1Scopus© Citations 1
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    Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research
    (2021)
    Jorge J. Llibre-Guerra
    ;
    BEHRENS PELLEGRINO, MARIA ISABEL  
    ;
    Mirna Lie Hosogi
    ;
    Lucia Montero
    ;
    Teresa Torralva
    <jats:p><jats:bold>Introduction:</jats:bold> The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.</jats:p><jats:p><jats:bold>Methods:</jats:bold> A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.</jats:p><jats:p><jats:bold>Results:</jats:bold> The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (<jats:italic>n</jats:italic> = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (<jats:italic>n</jats:italic> = 4), biomarkers (<jats:italic>n</jats:italic> = 9), or neuropathology (<jats:italic>n</jats:italic> = 3) of FTD.</jats:p><jats:p><jats:bold>Conclusions:</jats:bold> Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.</jats:p>
      1Scopus© Citations 13
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    The exposome of brain aging across 34 countries
    (Springer Science and Business Media LLC, 2026-04-03)
    Agustina Legaz
    ;
    Sebastian Moguilner
    ;
    Pablo Barttfeld
    ;
    Jhosmary Cuadros Castro
    ;
    Dante Sebastián Galván Rial
      1Scopus© Citations 10
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    1278 Feasibility of 48-h Ambulatory BP Assessment in Latinos with Dementia
    (Oxford University Press (OUP), 2025-05)
    Mili Jimenez Gallardo
    ;
    Andrea Castillo Suárez
    ;
    Peng Li
    ;
    Ramon C Hermida
    ;
    Michael Smolensky
    Abstract Introduction Ambulatory blood pressure (BP) monitoring encapsulates 24-h BP patterns across the sleep-wake cycle and provides a comprehensive assessment of BP regulation with certain features, such as sleep-time dipping, that can better predict health outcomes than traditional office BP measurements. However, 24-h BP patterns remain understudied in Latino populations, especially older adults. This pilot study investigated the feasibility of continuously ambulatory BP monitoring blood pressure with portable devices in Latinos with dementia. Methods Eight participants (4 with Alzheimer’s disease, 1 with Frontotemporal dementia, 3 controls; age range 45.8-80.3 years) from the ReDLat cohort (Multi-Partner Consortium to Expand Dementia Research in Latin America) were enrolled for a 48-h ambulatory BP assessment with hourly measurements using a portable arm-cuff device. Participants also answered six questions to evaluate: (1) device adaption, (2) measurement frequency tolerability, (3) study duration acceptability, (4) perceived value of the assessment, (5) willingness to perform the assessment again, and (6) likelihood of recommending the assessment to others. Results The study yielded high-quality recordings with minimal missing BP measurements (range: 0%-14.1%; mean: 8.9%). Device adaptation improved over time, with 75% (6/8) reporting better tolerance on the second day and 25% (2/8) reporting consistently good tolerance across both days. All participants reported that hourly BP measurement was tolerable, and majority (7/8, 87.5%) found 48-h monitoring acceptable. Seven participants (87.5%) believed that the assessment was valuable, were willing to participate again, and likely recommend to others the assessment. Conclusion Our findings demonstrate that 48-hour ambulatory BP monitoring is feasible and well-tolerated among older Latino adults with mild to moderate dementia in Latin American settings. Further feasibility testing should be performed in large samples and other populations, including individuals at later stages of dementia and in different countries.
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