Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following A cut Intracerebral Hemorrhage: Results of the INTERACT Studies
Journal
Cerebrovascular Diseases Extra
ISSN
1664-5456
Date Issued
2016
Author(s)
Edward Chan
Craig S. Anderson
Xia Wang
Hisatomi Arima
Anubhav Saxena
Tom J. Moullaali
Candice Delcourt
Guojun Wu
Jinchao Wang
Guofang Chen
Christian Stapf
Thompson Robinson
John Chalmers
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p><b><i>Background:</i></b> Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. <b><i>Aim:</i></b> To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth. <b><i>Methods:</i></b> Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance. <b><i>Results:</i></b> There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26). <b><i>Conclusions:</i></b> Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.</jats:p>
Subjects
stroke
;
intracerebral hemorrhage
;
intraventricular hemorrhage
;
hypertension
;
intensive blood pressure lowering