Clinical Predictive Model of Multidrug Resistance in Neutropenic Cancer Patients with Bloodstream Infection Due to Pseudomonas aeruginosa

Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
1098-6596
Date Issued
2020
Author(s)
C. Gudiol
A. Albasanz-Puig
J. Laporte-Amargós
N. Pallarès
A. Mussetti
I. Ruiz-Camps
P. Puerta-Alcalde
E. Abdala
C. Oltolini
M. Akova
M. Montejo
M. Mikulska
P. Martín-Dávila
F. Herrera
O. Gasch
L. Drgona
H. Paz Morales
A.-S. Brunel
E. García
B. Isler
W. V. Kern
I. Morales
G. Maestro-de la Calle
M. Montero
S. S. Kanj
O. R. Sipahi
S. Calik
I. Márquez-Gómez
J. I. Marin
M. Z. R. Gomes
P. Hemmatti
M. Peghin
J. L. del Pozo
L. Yáñez
R. Tilley
A. Manzur
A. Novo
J. Carratalà
Guillermo Cuervo
Francesc Escrihuela-Vidal
Fe Tubau
Cristian Tebé
Marisol Rodríguez Arias
Juan Aguilar-Company
Nieves Larrosa
Celia Cardozo
Carolina Garcia-Vidal
Ibrahim Karim-Yaqub
Raffaella Greco
Paola Cichero
Caglayan Merve Ayaz
Roberto Céspedes
Leire López-Soria
Laura Magnasco
Jesús Fortún
Diego Torres
Anna Boté
Mateu Espasa
Mia Hold Montaguti
Pierre-Yves Bochud
Oriol Manuel
Salvador Tabares Carrasco
Josefina Serrano López
Hartmut Bertz
Siegbert Rieg
Marina de Cueto
Jesús Rodríguez-Baño
Manuel Lizasoain
José María Aguado
Juan Pablo Horcajada
Saeed El Zein
Jean-Francois Jabbour
Ayse Uyan-Onal
Arzu Nazli-Zeka
Begoña Palop
Lina Clemencia Correa
Amanda Aparecida da Silva Machado
João Pedro Silva Tonhá
Georg Maschmeyer
Matteo Bassetti
Nadia Castaldo
Paloma Sangro del Alcázar
Type
Resource Types::text::journal::journal article
Scopus ID
2-s2.0-85082386308
WoS ID
WOS:000521752600065
DOI
URL
URL Institutional Repository
Abstract
<jats:p>
We aimed to assess the rate and predictive factors of bloodstream infection (BSI) due to multidrug-resistant (MDR)
<jats:named-content content-type="genus-species">Pseudomonas aeruginosa</jats:named-content>
in neutropenic cancer patients. We performed a multicenter, retrospective cohort study including oncohematological neutropenic patients with BSI due to
<jats:named-content content-type="genus-species">P. aeruginosa</jats:named-content>
conducted across 34 centers in 12 countries from January 2006 to May 2018. A mixed logistic regression model was used to estimate a model to predict the multidrug resistance of the causative pathogens.
</jats:p>
Cite this document
Gudiol, C., Albasanz-Puig, A., Laporte-Amargós, J., Pallarès, N., Mussetti, A., Ruiz-Camps, I., Puerta-Alcalde, P., Abdala, E., Oltolini, C., Akova, M., Montejo, M., Mikulska, M., Martín-Dávila, P., Herrera, F., Gasch, O., Drgona, L., Paz Morales, H., Brunel, A.-S., García, E., … Del Alcázar, P. S. (2020). Clinical predictive model of multidrug resistance in neutropenic cancer patients with bloodstream infection due to pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy, 64(4), e02494-19. https://doi.org/10.1128/AAC.02494-19
Subjects
multidrug resistant

; 

pseudomonas aeruginosa

; 

bacteremia

; 

bloodstream infection

; 

neutropenia

; 

cancer

; 

risk factors

; 

predictive model

; 

anti-bacterial agents

; 

bacteremia

; 

drug resistance, multiple, bacterial

; 

female

; 

humans

; 

male

; 

microbial sensitivity tests

; 

middle aged

; 

models, biological

; 

neoplasms

; 

neutropenia

; 

pseudomonas aeruginosa

; 

pseudomonas infections

; 

retrospective studies

; 

risk factors

; 

roc curve

; 

treatment outcome

; 

amikacin

; 

avibactam plus ceftazidime

; 

carbapenem

; 

cefepime

; 

ceftazidime

; 

ceftolozane plus tazobactam

; 

ciprofloxacin

; 

colistin

; 

fosfomycin

; 

imipenem

; 

meropenem

; 

piperacillin plus tazobactam

; 

quinoline derived antiinfective agent

; 

tobramycin

; 

antiinfective agent

; 

acute leukemia

; 

adult

; 

age

; 

antibiotic prophylaxis

; 

antibiotic sensitivity

; 

antibiotic therapy

; 

article

; 

bloodstream infection

; 

cancer patient

; 

case fatality rate

; 

cohort analysis

; 

female

; 

hematologic disease

; 

hematologic malignancy

; 

high risk patient

; 

human

; 

infection rate

; 

lung cancer

; 

major clinical study

; 

male

; 

middle aged

; 

multicenter study (topic)

; 

multidrug resistance

; 

neutropenia

; 

nonhuman

; 

predictor variable

; 

priority journal

; 

pseudomonas aeruginosa

; 

retrospective study

; 

solid malignant neoplasm

; 

bacteremia

; 

biological model

; 

clinical trial

; 

complication

; 

drug effect

; 

microbial sensitivity test

; 

microbiology

; 

multicenter study

; 

neoplasm

; 

neutropenia

; 

pseudomonas aeruginosa

; 

pseudomonas infection

; 

receiver operating characteristic

; 

risk factor

; 

treatment outcome