Extranodal Follicular Dendritic Cell Sarcoma Presenting on the Skin
Journal
The American Journal of Dermatopathology
ISSN
0193-1091
Date Issued
2024
Author(s)
Type
journal-article
Abstract
<jats:title>Abstract:</jats:title>
<jats:p>Follicular dendritic cell sarcoma is a rare intermediate-grade malignancy characterized by a proliferation of ovoid to spindle-shaped cells with morphologic and immunophenotypic features similar to normal follicular dendritic cells. It may develop in lymph nodes or extranodal sites. Its presentation in extranodal tissues is a diagnostic challenge. It requires a high index of suspicion because follicular dendritic cell markers are not included in the routine immunohistochemical panels used for differential diagnosis. In an extensive review of the English literature, we found 3 cases of follicular dendritic cell sarcoma developing on the skin. We report a case of a primary cutaneous follicular dendritic cell sarcoma in a 28-year-old man, which presented as a 6-mm skin-colored nodule on the right forearm. We describe the morphologic and immunohistochemical features and a review of the literature.</jats:p>
<jats:p>Follicular dendritic cell sarcoma is a rare intermediate-grade malignancy characterized by a proliferation of ovoid to spindle-shaped cells with morphologic and immunophenotypic features similar to normal follicular dendritic cells. It may develop in lymph nodes or extranodal sites. Its presentation in extranodal tissues is a diagnostic challenge. It requires a high index of suspicion because follicular dendritic cell markers are not included in the routine immunohistochemical panels used for differential diagnosis. In an extensive review of the English literature, we found 3 cases of follicular dendritic cell sarcoma developing on the skin. We report a case of a primary cutaneous follicular dendritic cell sarcoma in a 28-year-old man, which presented as a 6-mm skin-colored nodule on the right forearm. We describe the morphologic and immunohistochemical features and a review of the literature.</jats:p>
Cite this document
Agüero, R., Reculé, F., Pérez, J., & Castro, A. (2024). Extranodal follicular dendritic cell sarcoma presenting on the skin. The American Journal of Dermatopathology, 46(4), 218-222. https://doi.org/10.1097/DAD.0000000000002639
Subjects
follicular dendritic cell
;
sarcoma
;
immunohistochemistry