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Project Title
Mecanismos cognitivos y neurobiológicos de la cohesión social: fútbol como modelo de afiliación y conflictividad intergrupal
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Internal ID
1190513
Principal Investigator
Zamorano Mendieta, Francisco
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Publication

Neural Dynamics of Improved Bimodal Attention and Working Memory in Musically Trained Children

2020 , Leonie Kausel , Francisco Zamorano , BILLEKE BOBADILLA, PABLO ERNESTO , Mary E. Sutherland , Josefina Larrain-Valenzuela , Gottfried Schlaug , STECHER GUZMAN, XIMENA PATRICIA , Francisco Aboitiz

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Lateral Prefrontal Theta Oscillations Reflect Proactive Cognitive Control Impairment in Males With Attention Deficit Hyperactivity Disorder

2020 , Francisco Zamorano , Leonie Kausel , ALBORNOZ, CARLOS , Claudio Lavin , Alejandra Figueroa-Vargas , STECHER GUZMAN, XIMENA PATRICIA , Diego Aragón-Caqueo , Ximena Carrasco , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

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Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

2020 , Alejandra Figueroa-Vargas , Claudia Cárcamo , Rodrigo Henríquez-Ch , ZAMORANO, FRANCISCO , Ethel Ciampi , Reinaldo Uribe-San-Martin , Macarena Vásquez , Francisco Aboitiz , BILLEKE BOBADILLA, PABLO ERNESTO

AbstractWorking Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.

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