Project Title
Carbon monoxide inhibits Cx46 HCs through a lipid peroxidation-dependent process which increases Cx46- Ca2+ sensitivity
Partner Organisations
Internal ID
1160227
Principal Investigator
Type
basic research
Status
TERMINADO
Start Date
March 16, 2016
End Date
March 20, 2016
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Item type:Publication, Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala(2022)2Scopus© Citations 36 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Connexin-46 Contained in Extracellular Vesicles Enhance Malignancy Features in Breast Cancer Cells(2020); ; <jats:p>Under normal conditions, almost all cell types communicate with their neighboring cells through gap junction channels (GJC), facilitating cellular and tissue homeostasis. A GJC is formed by the interaction of two hemichannels; each one of these hemichannels in turn is formed by six subunits of transmembrane proteins called connexins (Cx). For many years, it was believed that the loss of GJC-mediated intercellular communication was a hallmark in cancer development. However, nowadays this paradigm is changing. The connexin 46 (Cx46), which is almost exclusively expressed in the eye lens, is upregulated in human breast cancer, and is correlated with tumor growth in a Xenograft mouse model. On the other hand, extracellular vesicles (EVs) have an important role in long-distance communication under physiological conditions. In the last decade, EVs also have been recognized as key players in cancer aggressiveness. The aim of this work was to explore the involvement of Cx46 in EV-mediated intercellular communication. Here, we demonstrated for the first time, that Cx46 is contained in EVs released from breast cancer cells overexpressing Cx46 (EVs-Cx46). This EV-Cx46 facilitates the interaction between EVs and the recipient cell resulting in an increase in their migration and invasion properties. Our results suggest that EV-Cx46 could be a marker of cancer malignancy and open the possibility to consider Cx46 as a new therapeutic target in cancer treatment.</jats:p>3Scopus© Citations 29 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Connexin43 Hemichannels in Satellite Glial Cells, Can They Influence Sensory Neuron Activity?(2017); 3Scopus© Citations 35 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release(2024)8Scopus© Citations 31 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Topical Application of Connexin43 Hemichannel Blocker Reduces Carotid Body-Mediated Chemoreflex Drive in Rats(2018)3Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extracellular Cysteines Are Critical to Form Functional Cx46 Hemichannels(2022)2Scopus© Citations 6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens(2022); Guillermo A. Altenberg<jats:p>Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular milieu. Gap junction channels are formed by head-to-head docking of two hemichannels in series, each one from one of two adjacent cells. These channels allow for exchanges between the cytoplasms of contacting cells. The lens is a transparent structure located in the eye that focuses light on the retina. The transparency of the lens depends on its lack of blood irrigation and the absence of organelles in its cells. To survive such complex metabolic scenario, lens cells express Cx43, Cx46 and Cx50, three connexins isoforms that form hemichannels and gap junction channels that allow for metabolic cooperation between lens cells. This review focuses on the roles of Cx46 hemichannels and gap junction channels in the lens under physiological conditions and in the formation of cataracts, with emphasis on the modulation by posttranslational modifications.</jats:p>6Scopus© Citations 10 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity(2023)2Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 2Scopus© Citations 9 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Over-activated hemichannels: A possible therapeutic target for human diseases(2021)13Scopus© Citations 14