Project Title
Carbon monoxide inhibits Cx46 HCs through a lipid peroxidation-dependent process which increases Cx46- Ca2+ sensitivity
Partner Organisations
Internal ID
1160227
Principal Investigator
Type
basic research
Status
TERMINADO
Start Date
March 16, 2016
End Date
March 20, 2016
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Item type:Publication, Charged Residues at the First Transmembrane Region Contribute to the Voltage Dependence of the Slow Gate of Connexins(2016); AgustĂn D. MartĂnez2Scopus© Citations 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release(2024)Scopus© Citations 5 8 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Connexin and Pannexin-Based Channels in Oligodendrocytes: Implications in Brain Health and Disease(2019); 7Scopus© Citations 28 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Role and Posttranslational Regulation of Cx46 Hemichannels and Gap Junction Channels in the Eye Lens(2022); Guillermo A. Altenberg<jats:p>Connexins are a family of proteins that can form two distinct types of channels: hemichannels and gap junction channels. Hemichannels are composed of six connexin subunits and when open allow for exchanges between the cytoplasm and the extracellular milieu. Gap junction channels are formed by head-to-head docking of two hemichannels in series, each one from one of two adjacent cells. These channels allow for exchanges between the cytoplasms of contacting cells. The lens is a transparent structure located in the eye that focuses light on the retina. The transparency of the lens depends on its lack of blood irrigation and the absence of organelles in its cells. To survive such complex metabolic scenario, lens cells express Cx43, Cx46 and Cx50, three connexins isoforms that form hemichannels and gap junction channels that allow for metabolic cooperation between lens cells. This review focuses on the roles of Cx46 hemichannels and gap junction channels in the lens under physiological conditions and in the formation of cataracts, with emphasis on the modulation by posttranslational modifications.</jats:p>6Scopus© Citations 8 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Extracellular Cysteines Are Critical to Form Functional Cx46 Hemichannels(2022)Scopus© Citations 6 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Over-activated hemichannels: A possible therapeutic target for human diseases(2021)Scopus© Citations 11 13 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Contribution of connexin hemichannels to the decreases in cell viability induced by linoleic acid in the human lens epithelial cells (HLE-B3)(2020); 8Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Activation of Intra-nodose Ganglion P2X7 Receptors Elicit Increases in Neuronal Activity(2023)Scopus© Citations 2 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 1Scopus© Citations 9 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Redox-mediated regulation of connexin proteins; focus on nitric oxide(2018)Scopus© Citations 24 2