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Microbleeds and the Effect of Anticoagulation in Patients With Embolic Stroke of Undetermined Source

2021 , Ashkan Shoamanesh , Robert G. Hart , Stuart J. Connolly , Scott E. Kasner , Eric E. Smith , Joan Martí-Fàbregas , Yan Yun Liu , Shinichiro Uchiyama , Robert Mikulik , Roland Veltkamp , Martin J. O’Donnell , George Ntaios , Keith W. Muir , Thalia S. Field , Gustavo C. Santo , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , Hardi Mundl , Helmi Lutsep , Scott D. Berkowitz , Mukul Sharma

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Authors, peer reviewers, and readers: What is expected from each player in collaborative publishing?

2021 , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA

Scholarly publishing is in a crisis, with the many stakeholders complaining about different aspects of the system. Authors want fast publication times, high visibility and publications in high-impact journals. Readers want freely accessible, high-quality articles. Peer reviewers want recognition for the work they perform to ensure the quality of the published articles. However, authors, peer reviewers, and readers are three different roles played by the same group of individuals, the users of the scholarly publishing system—and this system could work based on a collaborative publishing principle where “nobody pays, and nobody gets paid”.

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Risk Factors and Diet Components Determining Adherence to the Mediterranean Diet in Acute Ischemic Stroke Patients: A Cross-Sectional Analysis of a Prospective Hospital Register Study

2022 , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , NAVIA GONZALEZ, VICTOR HUGO , MAZZON AGURTO, ENRICO , Alexis Rojo , BRUNSER, ALEJANDRO , LAVADOS GERMAIN, PABLO MANUEL

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Low blood pressure and adverse outcomes in acute stroke: HeadPoST study explanations

2020 , Menglu Ouyang , MUÑOZ VENTURELLI, PAULA ANDREA , Laurent Billot , Xia Wang , Lili Song , Hisatomi Arima , LAVADOS GERMAIN, PABLO MANUEL , Maree L. Hackett , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , BRUNSER, ALEJANDRO , Sandy Middleton , Octavio M. Pontes-Neto , Tsong-Hai Lee , Caroline L. Watkins , Thompson Robinson , Craig S. Anderson

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Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

2021 , Raul G. Nogueira , Muhammad M. Qureshi , Mohamad Abdalkader , Sheila Ouriques Martins , Hiroshi Yamagami , Zhongming Qiu , Ossama Yassin Mansour , Anvitha Sathya , Anna Czlonkowska , Georgios Tsivgoulis , Diana Aguiar de Sousa , Jelle Demeestere , Robert Mikulik , Peter Vanacker , James E. Siegler , Janika Kõrv , Jose Biller , Conrad W. Liang , Navdeep S. Sangha , Alicia M. Zha , Alexandra L. Czap , Christine Anne Holmstedt , Tanya N. Turan , George Ntaios , Konark Malhotra , Ashis Tayal , Aaron Loochtan , Annamarei Ranta , Eva A. Mistry , Anne W. Alexandrov , David Y. Huang , Shadi Yaghi , Eytan Raz , Sunil A. Sheth , Mahmoud H. Mohammaden , Michael Frankel , Eric Guemekane Bila Lamou , Hany M. Aref , Ahmed Elbassiouny , Farouk Hassan , Tarek Menecie , Wessam Mustafa , Hossam M. Shokri , Tamer Roushdy , Fred S. Sarfo , Tolulope Oyetunde Alabi , Babawale Arabambi , Ernest O. Nwazor , Taofiki Ajao Sunmonu , Kolawole Wahab , Joseph Yaria , Haytham Hussein Mohammed , Philip B. Adebayo , Anis D. Riahi , Samia Ben Sassi , Lenon Gwaunza , Gift Wilson Ngwende , David Sahakyan , Aminur Rahman , Zhibing Ai , Fanghui Bai , Zhenhui Duan , Yonggang Hao , Wenguo Huang , Guangwen Li , Wei Li , Ganzhe Liu , Jun Luo , Xianjin Shang , Yi Sui , Ling Tian , Hongbin Wen , Bo Wu , Yuying Yan , Zhengzhou Yuan , Hao Zhang , Jun Zhang , Wenlong Zhao , Wenjie Zi , Thomas W. Leung , Chandril Chugh , Vikram Huded , Bindu Menon , Jeyaraj Durai Pandian , PN Sylaja , Fritz Sumantri Usman , Mehdi Farhoudi , Elyar Sadeghi Hokmabadi , Anat Horev , Anna Reznik , Rotem Sivan Hoffmann , Nobuyuki Ohara , Nobuyuki Sakai , Daisuke Watanabe , Ryoo Yamamoto , Ryosuke Doijiri , Naoki Tokuda , Takehiro Yamada , Tadashi Terasaki , Yukako Yazawa , Takeshi Uwatoko , Tomohisa Dembo , Hisao Shimizu , Yuri Sugiura , Fumio Miyashita , Hiroki Fukuda , Kosuke Miyake , Junsuke Shimbo , Yusuke Sugimura , Yoshiki Yagita , Yohei Takenobu , Yuji Matsumaru , Satoshi Yamada , Ryuhei Kono , Takuya Kanamaru , Hidekazu Yamazaki , Manabu Sakaguchi , Kenichi Todo , Nobuaki Yamamoto , Kazutaka Sonoda , Tomoko Yoshida , Hiroyuki Hashimoto , Ichiro Nakahara , Aida Kondybayeva , Kamila Faizullina , Saltanat Kamenova , Murat Zhanuzakov , Jang-Hyun Baek , Yangha Hwang , Jin Soo Lee , Si Baek Lee , Jusun Moon , Hyungjong Park , Jung Hwa Seo , Kwon-Duk Seo , Sung Il Sohn , Chang Jun Young , Rechdi Ahdab , Wan Asyraf Wan Zaidi , Zariah Abdul Aziz , Hamidon bin Basri , Law Wan Chung , Aznita Binti Ibrahim , Khairul Azmi Ibrahim , Irene Looi , Wee Yong Tan , Nafisah Wan Yahya , Stanislav Groppa , Pavel Leahu , Amal M. Al Hashmi , Yahia Zakaria Imam , Naveed Akhtar , Maria Carissa Pineda-Franks , Christian Oliver Co , Dmitriy Kandyba , Adel Alhazzani , Hosam Al-Jehani , Carol Huilian Tham , Marlie Jane Mamauag , Narayanaswamy Venketasubramanian , Chih-Hao Chen , Sung-Chun Tang , Anchalee Churojana , Esref Akil , özlem aykaç , Atilla Ozcan Ozdemir , Semih Giray , Syed Irteza Hussain , Seby John , Huynh Le Vu , Anh Duc Tran , Huy Hoang Nguyen , Thong Nhu Pham , Thang Huy Nguyen , Trung Quoc Nguyen , Thomas Gattringer , Christian Enzinger , Monika Killer-Oberpfalzer , Flavio Bellante , Sofie De Blauwe , Geert Vanhooren , Sylvie De Raedt , Anne Dusart , Robin Lemmens , Noemie Ligot , Matthieu Pierre Rutgers , Laetitia Yperzeele , Filip Alexiev , Teodora Sakelarova , Marina Roje Bedeković , Hrvoje Budincevic , Igor Cindric , Zlatko Hucika , David Ozretic , Majda Seferovic Saric , František Pfeifer , Igor Karpowic , David Cernik , Martin Sramek , Miroslav Skoda , Helena Hlavacova , Lukas Klecka , Martin Koutny , Daniel Vaclavik , Ondrej Skoda , Jan Fiksa , Katerina Hanelova , Miroslava Nevsimalova , Robert Rezek , Petr Prochazka , Gabriela Krejstova , Jiri Neumann , Marta Vachova , Henryk Brzezanski , David Hlinovsky , Dusan Tenora , Rene Jura , Lubomír Jurák , Jan Novak , Ales Novak , Zdenek Topinka , Petr Fibrich , Helena Sobolova , Ondrej Volny , Hanne Krarup Christensen , Nicolas Drenck , Helle Klingenberg Iversen , Claus Z. Simonsen , Thomas Clement Truelsen , Troels Wienecke , Riina Vibo , Katrin Gross-Paju , Toomas Toomsoo , Katrin Antsov , Francois Caparros , Charlotte Cordonnier , Maria Dan , Jean-Marc Faucheux , Laura Mechtouff , Omer Eker , Emilie Lesaine , Basile Ondze , Roxane Peres , Fernando Pico , Michel Piotin , Raoul Pop , Francois Rouanet , Tatuli Gubeladze , Mirza Khinikadze , Nino Lobjanidze , Alexander Tsiskaridze , Simon Nagel , Peter Arthur Ringleb , Michael Rosenkranz , Holger Schmidt , Annahita Sedghi , Timo Siepmann , Kristina Szabo , Götz Thomalla , Lina Palaiodimou , Dimitrios Sagris , Odysseas Kargiotis , Peter Klivenyi , Laszlo Szapary , Gabor Tarkanyi , Alessandro Adami , Fabio Bandini , Paolo Calabresi , Giovanni Frisullo , Leonardo Renieri , Davide Sangalli , Anne Pirson , Maarten Uyttenboogaart , Ido van den Wijngaard , Espen Saxhaug Kristoffersen , Waldemar Brola , Małgorzata Fudala , Ewa Horoch-Lyszczarek , Michal Karlinski , Radoslaw Kazmierski , Pawel Kram , Marcin Rogoziewicz , Rafal Kaczorowski , Piotr Luchowski , Halina Sienkiewicz-Jarosz , Piotr Sobolewski , Waldemar Fryze , Anna Wisniewska , Malgorzata Wiszniewska , Patricia Ferreira , Paulo Ferreira , Luisa Fonseca , João Pedro Marto , Teresa Pinho e Melo , Ana Paiva Nunes , Miguel Rodrigues , Vítor Tedim Cruz , Cristian Falup-Pecurariu , Georgi Krastev , Miroslav Mako , María Alonso de Leciñana , Juan F. Arenillas , Oscar Ayo-Martin , Antonio Cruz Culebras , Exuperio Diez Tejedor , Joan Montaner , Soledad Pérez-Sánchez , Miguel Angel Tola Arribas , Alejandro Rodriguez Vasquez , Michael Mayza , Gianmarco Bernava , Alex Brehm , Paolo Machi , Urs Fischer , Jan Gralla , Patrik L. Michel , Marios-Nikos Psychogios , Davide Strambo , Soma Banerjee , Kailash Krishnan , Joseph Kwan , Asif Butt , Luciana Catanese , Andrew M. Demchuk , Thalia Field , Jennifer Haynes , Michael D. Hill , Houman Khosravani , Ariane Mackey , Aleksandra Pikula , Gustavo Saposnik , Courtney Anne Scott , Ashkan Shoamanesh , Ashfaq Shuaib , Samuel Yip , Miguel A. Barboza , Jose Domingo Barrientos , Ligia Ibeth Portillo Rivera , Fernando Gongora-Rivera , Nelson Novarro-Escudero , Anmylene Blanco , Michael Abraham , Diana Alsbrook , Dorothea Altschul , Anthony J. Alvarado-Ortiz , Ivo Bach , Aamir Badruddin , Nobl Barazangi , Charmaine Brereton , Alicia Castonguay , Seemant Chaturvedi , Saqib A. Chaudry , Hana Choe , Jae H. Choi , Sushrut Dharmadhikari , Kinjal Desai , Thomas G. Devlin , Vinodh T. Doss , Randall Edgell , Mark Etherton , Mudassir Farooqui , Don Frei , Dheeraj Gandhi , Mikayel Grigoryan , Rishi Gupta , Ameer E. Hassan , Johanna Helenius , Artem Kaliaev , Ritesh Kaushal , Priyank Khandelwal , Ayaz M. Khawaja , Naim N. Khoury , Benny S. Kim , Dawn O. Kleindorfer , Feliks Koyfman , Vivien H. Lee , Lester Y. Leung , Guillermo Linares , Italo Linfante , Helmi L. Lutsep , Lisa Macdougall , Shailesh Male , Amer M. Malik , Hesham Masoud , Molly McDermott , Brijesh P. Mehta , Jiangyong Min , Manoj Mittal , Jane G. Morris , Sumeet S. Multani , Fadi Nahab , Krishna Nalleballe , Claude B. Nguyen , Roberta Novakovic-White , Santiago Ortega-Gutierrez , Rahul H. Rahangdale , Pankajavalli Ramakrishnan , Jose Rafael Romero , Natalia Rost , Aaron Rothstein , Sean Ruland , Ruchir Shah , Malveeka Sharma , Brian Silver , Marc Simmons , Abhishek Singh , Amy K. Starosciak , Sheryl L. Strasser , Viktor Szeder , Mohamed Teleb , Jenny P. Tsai , Barbara Voetsch , Oscar Balaguera , Virginia A. Pujol Lereis , Adriana Luraschi , Marcele Schettini Almeida , Fabricio Buchdid Cardoso , Adriana Conforto , Leonardo De Deus Silva , Luidia Varrone Giacomini , Fabricio Oliveira Lima , Alexandre L. Longo , Pedro S.C. Magalhães , Rodrigo Targa Martins , Francisco Mont'alverne , Daissy Liliana Mora Cuervo , Leticia Costa Rebello , Lenise Valler , Viviane Flumignan Zetola , LAVADOS GERMAIN, PABLO MANUEL , Victor Navia , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , Juan Manuel Almeida Toro , Pablo Felipe Ricardo Amaya , Hernan Bayona , Angel Corredor , Carlos Eduardo Rivera Ordonez , Diana Katherine Mantilla Barbosa , Osvaldo Lara , Mauricio R. Patiño , Luis Fernando Diaz Escobar , Donoband Edson Dejesus Melgarejo Fariña , Analia Cardozo Villamayor , Adolfo Javier Zelaya Zarza , Danny Moises Barrientos Iman , Liliana Rodriguez Kadota , Bruce Campbell , Graeme J. Hankey , Casey Hair , Timothy Kleinig , Alice Ma , Rodrigo Tomazini Martins , Ramesh Sahathevan , Vincent Thijs , Daniel Salazar , Teddy Yuan-Hao Wu , Diogo C. Haussen , David Liebeskind , Dileep R. Yavagal , Tudor G. Jovin , Osama O. Zaidat , Thanh N. Nguyen

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In-Hospital Acute Ischemic Stroke is Associated with Worse Outcome: Experience of a Single Center in Santiago Chile

2021 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Patricia Araneda , NAVIA GONZALEZ, VICTOR HUGO , MAZZON AGURTO, ENRICO , Gabriel Cavada , MUÑOZ VENTURELLI, PAULA ANDREA , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , LAVADOS GERMAIN, PABLO MANUEL

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Who is in the emergency room matters when we talk about door-to-needle time: a single-center experience

2023 , BRUNSER RABOVICH, ALEJANDRO MICHEL , Juan-Cristobal Nuñez , Eloy Mansilla , Gabriel Cavada , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , MUÑOZ VENTURELLI, PAULA ANDREA , LAVADOS GERMAIN, PABLO MANUEL

Abstract Background The efficacy of intravenous thrombolysis (IVT) is time-dependent. Objective To compare the door-to-needle (DTN) time of stroke neurologists (SNs) versus non-stroke neurologists (NSNs) and emergency room physicians (EPs). Additionally, we aimed to determine elements associated with DTN ≤ 20 minutes. Methods Prospective study of patients with IVT treated at Clínica Alemana between June 2016 and September 2021. Results A total of 301 patients underwent treatment for IVT. The mean DTN time was 43.3 ± 23.6 minutes. One hundred seventy-three (57.4%) patients were evaluated by SNs, 122 (40.5%) by NSNs, and 6 (2.1%) by EPs. The mean DTN times were 40.8 ± 23, 46 ± 24.7, and 58 ± 22.5 minutes, respectively. Door-to-needle time ≤ 20 minutes occurred more frequently when patients were treated by SNs compared to NSNs and EPs: 15%, 4%, and 0%, respectively (odds ratio [OR]: 4.3, 95% confidence interval [95%CI]: 1.66–11.5, p = 0.004). In univariate analysis DTN time ≤ 20 minutes was associated with treatment by a SN (p = 0.002), coronavirus disease 2019 pandemic period (p = 0.21), time to emergency room (ER) (p = 0.21), presence of diabetes (p = 0.142), hypercholesterolemia (p = 0.007), atrial fibrillation (p < 0.09), score on the National Institutes of Health Stroke Scale (NIHSS) (p = 0.001), lower systolic (p = 0.143) and diastolic (p = 0.21) blood pressures, the Alberta Stroke Program Early CT Score (ASPECTS; p = 0.09), vessel occlusion (p = 0.05), use of tenecteplase (p = 0.18), thrombectomy (p = 0.13), and years of experience of the physician (p < 0.001). After multivariate analysis, being treated by a SN (OR: 3.95; 95%CI: 1.44–10.8; p = 0.007), NIHSS (OR: 1.07; 95%CI: 1.02–1.12; p < 0.002) and lower systolic blood pressure (OR: 0.98; 95%CI: 0.96–0.99; p < 0.003) remained significant. Conclusion Treatment by a SN resulted in a higher probability of treating the patient in a DTN time within 20 minutes.

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Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot)

2017 , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , Hisatomi Arima , Craig S Anderson , BRUNSER, ALEJANDRO , MUÑOZ VENTURELLI, PAULA ANDREA , Laurent Billot , LAVADOS GERMAIN, PABLO MANUEL

Background The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. The trial will test if lying flat head position initiated in patients within 12 h of onset of acute ischemic stroke involving the anterior circulation increases cerebral blood flow in the middle cerebral arteries, as measured by transcranial Doppler. The study will also assess the safety and feasibility of patients lying flat for ≥24 h. The trial was conducted in centers in three countries, with ability to perform early transcranial Doppler. A feature of this trial was that patients were randomized to a certain position according to the month of admission to hospital. Objective To outline in detail the predetermined statistical analysis plan for HEADPOST Pilot study. Methods All data collected by participating researchers will be reviewed and formally assessed. Information pertaining to the baseline characteristics of patients, their process of care, and the delivery of treatments will be classified, and for each item, appropriate descriptive statistical analyses are planned with comparisons made between randomized groups. For the outcomes, statistical comparisons to be made between groups are planned and described. Results This statistical analysis plan was developed for the analysis of the results of the HEADPOST Pilot study to be transparent, available, verifiable, and predetermined before data lock. Conclusions We have developed a statistical analysis plan for the HEADPOST Pilot study which is to be followed to avoid analysis bias arising from prior knowledge of the study findings. Trial registration The study is registered under HEADPOST-Pilot, ClinicalTrials.gov Identifier NCT01706094.

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Quantifying regional variations in components of acute stroke unit (ASU) care in the international HeadPoST study

2020 , Menglu Ouyang , Yao Zhang , Xia Wang , Lili Song , Laurent Billot , Thompson Robinson , LAVADOS GERMAIN, PABLO MANUEL , Hisatomi Arima , Maree L. Hackett , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , MUÑOZ VENTURELLI, PAULA ANDREA , Sandy Middleton , Caroline L. Watkins , Octavio M. Pontes-Neto , Tsong-Hai Lee , BRUNSER, ALEJANDRO , Craig S. Anderson

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Diffusion-weighted imaging as predictor of acute ischemic stroke etiology

2022 , Alejandro Michel Brunser , Eloy Mansilla , NAVIA GONZALEZ, VICTOR HUGO , MAZZON AGURTO, ENRICO , Alexis Rojo , Gabriel Cavada , OLAVARRIA IANISZEWSKY, VERONICA VIVIANA , LAVADOS GERMAIN, PABLO MANUEL , MUÑOZ VENTURELLI, PAULA ANDREA

Abstract Background: Topographic patterns may correlate with causes of ischemic stroke. Objective: To investigate the association between diffusion-weighted imaging (DWI) and Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Methods: We included 1019 ischemic stroke patients. DWI were classified as: i) negative; ii) DWI single lesion (cortico-subcortical, cortical, subcortical ≥20 mm, or subcortical <20 mm); iii) scattered lesions in one territory (small scattered lesions or confluent with additional lesions); and iv) multiple lesions (multiple unilateral anterior circulation [MAC], multiple posterior circulation [MPC], multiple bilateral anterior circulation [MBAC], and multiple anterior and posterior circulations [MAP]). Results: There was a relationship between DWI patterns and TOAST classification (p<0.001). Large artery atherosclerosis was associated with small, scattered lesions in one vascular territory (Odds Ratio [OR] 4.22, 95% confidence interval [95%CI] 2.61–6.8), MPC (OR 3.52; 95%CI 1.54–8.03), and subcortical lesions <20 mm (OR 3.47; 95%CI 1.76–6.85). Cardioembolic strokes correlated with MAP (OR 4.3; 95%CI 1.64–11.2), cortico-subcortical lesions (OR 3.24; 95%CI 1.9–5.5) and negative DWI (OR 2.46; 95%CI 1.1–5.49). Cryptogenic strokes correlated with negative DWI (OR 4.1; 95%CI 1,84–8.69), cortical strokes (OR 3.3; 95%CI 1.25–8.8), MAP (OR 3.33; 95%CI 1.25–8.81) and subcortical lesion ≥20 mm (OR 2.44; 95%CI 1,04–5.73). Lacunar strokes correlated with subcortical lesions diameter <20 mm (OR 42.9; 95%CI 22.7–81.1) and negative DWI (OR 8.87; 95%CI 4.03–19.5). Finally, MBAC (OR 9.25; 95%CI 1.12–76.2), MAP (OR 5.54; 95%CI 1.94–15.1), and MPC (OR 3.61; 95%CI 1.5–8.7) correlated with stroke of other etiologies. Conclusions: A relationship exists between DWI and stroke subtype.