SILVA GONZALEZ, NATALY ROXANA
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SILVA GONZALEZ, NATALY ROXANA
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nrsilva@udd.cl
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35176687400

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2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0 3.5 3.5 4.0 4.0

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Mapping experimental and theoretical reactivity descriptors of fe macrocyclic complexes deposited on graphite or on multi walled carbon nanotubes for the oxidation of thiols: Thioglycolic acid oxidation

2021 , Ricardo A. Matute , Alejandro Toro-Labbé , María P. Oyarzún , Sara Ramirez , Daniela E. Ortega , Karina Oyarce , SILVA GONZALEZ, NATALY ROXANA , José H. Zagal

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β-Cyclodextrin Nanosponges Inclusion Compounds Associated with Silver Nanoparticles to Increase the Antimicrobial Activity of Quercetin

2023 , Sebastián Salazar Sandoval , Tamara Bruna , Francisca Maldonado-Bravo , Karen Bolaños , Sofía Adasme-Reyes , Ana Riveros , Nelson Caro , Nicolás Yutronic , SILVA GONZALEZ, NATALY ROXANA , Marcelo J. Kogan , Paul Jara

This work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical limitations of QRC. The host–guest interaction between NSs and QRC was confirmed by field emission scanning electron microscopy (FE–SEM), X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H–NMR). Moreover, the association of AgNPs with the NS–QRC was characterized using FE–SEM, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ-potential, and UV–Vis. Finally, the antimicrobial activity of the novel formulations was tested, which depicted that the complexation of QRC inside the supramolecular interstices of NSs increases the inhibitory effects against Escherichia coli ATCC25922, as compared to that observed in the free QRC. In addition, at the same concentrations used to generate an antibacterial effect, the NS–QRC system with AgNPs does not affect the metabolic activity of GES–1 cells. Therefore, these results suggest that the use of NSs associated with AgNPs resulted in an efficient strategy to improve the physicochemical features of QRC.

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Nanomaterials Based on Honey and Propolis for Wound Healing—A Mini-Review

2022 , Limberg Jaldin-Crespo , SILVA GONZALEZ, NATALY ROXANA , MARTINEZ ARENAS, JESSICA ISABEL

Wound healing is a public health concern worldwide, particularly in chronic wounds due to delayed healing and susceptibility to bacterial infection. Nanomaterials are widely used in wound healing treatments due to their unique properties associated with their size and very large surface-area-to-volume ratio compared to the same material in bulk. The properties of nanomaterials can be expanded and improved upon with the addition of honey and propolis, due to the presence of bioactive molecules such as polyphenols, flavonoids, peptides, and enzymes. These bionanomaterials can act at different stages of wound healing and through different mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulation, cell proliferation, and angiogenic effects. Biomaterials, at the nanoscale, show new alternatives for wound therapy, allowing for targeted and continuous delivery of beekeeping products at the injection site, thus avoiding possible systemic adverse effects. Here, we summarize the most recent therapies for wound healing based on bionanomaterials assisted by honey and propolis, with a focus on in vitro and in vivo studies. We highlight the type, composition (honey, propolis, and polymeric scaffolds), biological, physicochemical/mechanical properties, potential applications and patents related of the last eight years. Furthermore, we discuss the challenges, advantages, disadvantages and stability of different bionanomaterials related to their clinical translation and insight into the investigation and development of new treatments for wound healing.

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Advances in the Sustainable Development of Biobased Materials Using Plant and Animal Waste as Raw Materials: A Review

2024 , Sebastián Salazar Sandoval , AMENÁBAR FIGUEROA, ALEJANDRA , TOLEDO ROMÁN, IGNACIO GALVARINO , SILVA GONZALEZ, NATALY ROXANA , CONTRERAS CORREA, PAULINA DEL PILAR

There is substantial concern about critical environmental problems related to waste in production sectors such as textile, construction, and packaging. The materials ascribed to the sector’s unsustainability are primarily fabrics, plastic, and hazardous solvents, making developing new biobased materials imperative. As such, various strategies have been investigated to convert and recycle waste and give them commercial value via the manufacture of biobased materials. This review discusses the various types of raw materials as sources to develop new biobased materials that could promote the transition toward sustainability. According to the literature, the functional qualities of biobased materials are comparable to those of synthetic materials. Raw material sources such as biomass, derived from plant and animal-based waste, are attractive due to their low cost, abundance, and biodegradability. The manufacture of biomaterials, as well as their characterization and performance, are also discussed. Further, this review will offer a comprehensive view of the potential applicability and current commercial applications of the developed biobased materials in relevant areas such as packaging, construction, textile, and wastewater remediation. This could be a potential field of research to address the environmental challenges posed by the continuous growth of the global population.

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Controlled Release of the Anticancer Drug Cyclophosphamide from a Superparamagnetic β-Cyclodextrin Nanosponge by Local Hyperthermia Generated by an Alternating Magnetic Field

2024 , Sebastián Salazar Sandoval , Patricia Díaz-Saldívar , Ingrid Araya , Freddy Celis , Diego Cortés-Arriagada , Ana Riveros , Carlos Rojas-Romo , Carolina Jullian , SILVA GONZALEZ, NATALY ROXANA , Nicolás Yutronic , Marcelo J. Kogan , Paul Jara

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Oxide copper nanoparticles stabilized by acrylonitrile and methyl methacrylate polar monomers through a ligand exchange reaction

2021 , Bárbara Rodríguez , Sara Ramírez , Pablo Gutiérrez , SILVA GONZALEZ, NATALY ROXANA , Isaac Díaz-Aburto , Andreina García , Iván Martínez

Abstract This research reports the synthesis of copper oxide nanoparticles (CuONP) functionalized by the polar monomers acrylonitrile (ACN) and methyl methacrylate (MMA). The synthesis was achieved by a practical exchange ligand reaction from CuONP previously stabilized by hexadecyltrimethylammonium bromide (CTAB). The replacement of CTAB by ACN or MMA produced the functionalized nanoparticles CuONP-ACN and CuONP-MMA, respectively. The functionalized nanoparticles were characterized by ultraviolet-visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (SEM), dynamic light scattering (DLS), Zeta potential, x-ray diffraction (XRD), high-resolution-transmission electron microscopy (HR-TEM), and selected area electron diffraction (SAED) analysis. Changes in surface plasmon resonance (SPR) band and the functional group bands observed in UV–vis and FTIR spectra confirmed the efficient replacement of CTAB by polar monomers. Moreover, CuONP-ACN and CuONP-MMA showed a negative surface charge with spherical morphology. X-ray diffraction (XRD) analysis showed that a monoclinic CuO crystal system was formed.

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Correlation between the concentration and morphology of copper microparticles and their biocidal effect on paper sheets

2020 , P. Contreras , A. Amenabar , V. Apablaza , MARTINEZ ARENAS, JESSICA ISABEL , R. Lavín , SILVA GONZALEZ, NATALY ROXANA

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Modulation of the electrocatalytic activity of Fe phthalocyanine to carbon nanotubes: Electrochemistry of l-cysteine and l-cystine

2019 , SILVA GONZALEZ, NATALY ROXANA , C. Castro-Castillo , M.P. Oyarzún , S. Ramírez , C. Gutierrez-Ceron , J.F. Marco , J.F. Silva , J.H. Zagal

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Testing Reactivity Descriptors for the Electrocatalytic Activity of OPG Hybrid Electrodes Modified with Iron Macrocyclic Complexes and MWCNTs for the Oxidation of Reduced Glutathione in Basic Medium

2019 , C. Gutiérrez-Cerón , SILVA GONZALEZ, NATALY ROXANA , I. Ponce , J. H. Zagal

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Synthesis and Characterization of Magnetite/Gold Core Shell Nanoparticles Stabilized with a β-Cyclodextrin Nanosponge to Develop a Magneto-Plasmonic System

2023 , Sebastián Salazar Sandoval , Daniel Santibáñez , Ana Riveros , Fabián Araneda , Tamara Bruna , SILVA GONZALEZ, NATALY ROXANA , Nicolás Yutronic , Marcelo J. Kogan , Paul Jara

Magnetite/gold core-shell nanoparticles (magnetite/gold NPs) have important optical and magnetic properties that provide potential for applications, especially biomedical ones. However, their preparation is not exempt from difficulties that might lead to unexpected or undesired structures. This work reports the synthesis and characterization of magnetite/gold NPs using tetramethylammonium hydroxide (TMAH) to promote the formation of a continuous interface between the magnetite core and the thin gold shell. The synthesized magnetite/gold NPs were characterized using transmission electron microscopy (TEM), energy-dispersive spectroscopy (EDS), field emission scanning electron microscope (FE-SEM), ζ-potential, vibrating sample magnetometer (VSM), selected area electron diffraction (SAED), UV-Visible spectroscopy, and dynamic light scattering (DLS), confirming the core-shell structure of the NPs with narrow size distribution while evidencing its plasmonic and superparamagnetic properties as well. Further, the magnetite/gold NPs were associated and stabilized with a β-cyclodextrin nanosponge (β-CDNSs), obtaining a versatile magneto-plasmonic system for potential applications in the encapsulation and controlled release of drugs.

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