β-Cyclodextrin Nanosponges Inclusion Compounds Associated with Silver Nanoparticles to Increase the Antimicrobial Activity of Quercetin
Journal
Materials
ISSN
1996-1944
Date Issued
2023
Author(s)
Sebastián Salazar Sandoval
Tamara Bruna
Francisca Maldonado-Bravo
Karen Bolaños
Sofía Adasme-Reyes
Ana Riveros
Nelson Caro
Nicolás Yutronic
Marcelo J. Kogan
Paul Jara
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>This work aimed to synthesize and characterize a nanocarrier that consisted of a ternary system, namely β-cyclodextrin-based nanosponge (NS) inclusion compounds (ICs) associated with silver nanoparticles (AgNPs) to increase the antimicrobial activity of quercetin (QRC). The nanosystem was developed to overcome the therapeutical limitations of QRC. The host–guest interaction between NSs and QRC was confirmed by field emission scanning electron microscopy (FE–SEM), X-ray powder diffraction (XRPD), thermogravimetric analysis (TGA), and proton nuclear magnetic resonance (1H–NMR). Moreover, the association of AgNPs with the NS–QRC was characterized using FE–SEM, energy-dispersive spectroscopy (EDS), transmission electron microscopy (TEM), dynamic light scattering (DLS), ζ-potential, and UV–Vis. Finally, the antimicrobial activity of the novel formulations was tested, which depicted that the complexation of QRC inside the supramolecular interstices of NSs increases the inhibitory effects against Escherichia coli ATCC25922, as compared to that observed in the free QRC. In addition, at the same concentrations used to generate an antibacterial effect, the NS–QRC system with AgNPs does not affect the metabolic activity of GES–1 cells. Therefore, these results suggest that the use of NSs associated with AgNPs resulted in an efficient strategy to improve the physicochemical features of QRC.</jats:p>
Subjects
antimicrobial activity
;
antimicrobials
;
plasmon surface resonance
;
quercetin
;
silver nanoparticles
;
β-cyclodextrin-based nanosponges
;
cyclodextrins
;
dynamic light scattering
;
energy dispersive spectroscopy
;
escherichia coli
;
field emission microscopes
;
flavonoids
;
high resolution transmission electron microscopy
;
metal nanoparticles
;
nuclear magnetic resonance
;
nuclear magnetic resonance spectroscopy
;
phenols
;
scanning electron microscopy
;
synthesis (chemical)
;
thermogravimetric analysis
;
x ray powder diffraction
;
anti-microbial activity
;
antimicrobial
;
field emission scanning electron microscopy
;
host guest interactions
;
inclusion compounds
;
nanocarriers
;
nanosponge
;
plasmon surface resonance
;
quercetin
;
β-cyclodextrin-based nanosponge
;
silver nanoparticles