BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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BEHRENS PELLEGRINO, MARIA ISABEL
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mbehrens@udd.cl
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7007110355

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2024 2024 2023 2023 2022 2022 2021 2021 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0

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The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

2023 , Pavel Prado , Vicente Medel , Raul Gonzalez-Gomez , Agustín Sainz-Ballesteros , Victor Vidal , Hernando Santamaría-García , Sebastian Moguilner , Jhony Mejia , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL , David Aguillon , Francisco Lopera , Mario A. Parra , Diana Matallana , Marcelo Adrián Maito , Adolfo M. Garcia , Nilton Custodio , Alberto Ávila Funes , Stefanie Piña-Escudero , Agustina Birba , Sol Fittipaldi , Agustina Legaz , Agustín Ibañez

The Latin American Brain Health Institute (BrainLat) has released a unique multimodal neuroimaging dataset of 780 participants from Latin American. The dataset includes 530 patients with neurodegenerative diseases such as Alzheimer’s disease (AD), behavioral variant frontotemporal dementia (bvFTD), multiple sclerosis (MS), Parkinson’s disease (PD), and 250 healthy controls (HCs). This dataset (62.7 ± 9.5 years, age range 21–89 years) was collected through a multicentric effort across five Latin American countries to address the need for affordable, scalable, and available biomarkers in regions with larger inequities. The BrainLat is the first regional collection of clinical and cognitive assessments, anatomical magnetic resonance imaging (MRI), resting-state functional MRI (fMRI), diffusion-weighted MRI (DWI), and high density resting-state electroencephalography (EEG) in dementia patients. In addition, it includes demographic information about harmonized recruitment and assessment protocols. The dataset is publicly available to encourage further research and development of tools and health applications for neurodegeneration based on multimodal neuroimaging, promoting the assessment of regional variability and inclusion of underrepresented participants in research.

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Biomarkers for dementia in Latin American countries: Gaps and opportunities

2022 , Mario A. Parra , ORELLANA VILLENA, VIVIANA PAULINA , Tomas Leon , Cabello G. Victoria , Rodrigo Gomez , Fernando Henriquez , Constanza Avalos , Andres Damian , Agustin Ibañez , Henrik Zetterberg , SLACHEVSKY CHONCHOL, ANDREA MARÍA , Betty M. Tijms , Jennifer S. Yokoyama , Stefanie D. Piña‐Escudero , J. Nicholas Cochran , Diana L. Matallana , Daisy Acosta , Ricardo Allegri , Bianca P. Arias‐Suárez , Bernardo Barra , Sonia M. D. Brucki , Geraldo Busatto , Paulo Caramelli , Sheila Castro‐Suarez , BEHRENS PELLEGRINO, MARIA ISABEL , Valeria Contreras , Nilton Custodio , Sergio Dansilio , Myriam De la Cruz‐Puebla , Leonardo Cruz de Souza , Monica M. Diaz , Lissette Duque , Gonzalo A. Farías , Sergio T. Ferreira , Nahuel Magrath Guimet , Ana Kmaid , David Lira , Francisco Lopera , Beatriz Mar Meza , Eliane C. Miotto , Ricardo Nitrini , Alberto Nuñez , Santiago O'Neill , John Ochoa , Maritza Pintado‐Caipa , Elisa de Paula França Resende , Shannon Risacher , Luz Angela Rojas , Valentina Sabaj , Lucas Schilling , Allis F. Sellek , Ana Sosa , Leonel T. Takada , Antonio L. Teixeira , Martha Unaucho‐Pilalumbo , Claudia Duran‐Aniotz

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Author Correction: Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

2024 , Sebastian Moguilner , Sandra Baez , Hernan Hernandez , Joaquín Migeot , Agustina Legaz , Raul Gonzalez-Gomez , Francesca R. Farina , Pavel Prado , Jhosmary Cuadros , Enzo Tagliazucchi , Florencia Altschuler , Marcelo Adrián Maito , María E. Godoy , Josephine Cruzat , Pedro A. Valdes-Sosa , Francisco Lopera , John Fredy Ochoa-Gómez , Alfredis Gonzalez Hernandez , Jasmin Bonilla-Santos , Rodrigo A. Gonzalez-Montealegre , Renato Anghinah , Luís E. d’Almeida Manfrinati , Sol Fittipaldi , Vicente Medel , Daniela Olivares , Görsev G. Yener , Javier Escudero , Claudio Babiloni , Robert Whelan , Bahar Güntekin , Harun Yırıkoğulları , Hernando Santamaria-Garcia , Alberto Fernández Lucas , David Huepe , Gaetano Di Caterina , Marcio Soto-Añari , Agustina Birba , Agustin Sainz-Ballesteros , Carlos Coronel-Oliveros , Amanuel Yigezu , Eduar Herrera , Daniel Abasolo , Kerry Kilborn , Nicolás Rubido , Ruaridh A. Clark , Ruben Herzog , Deniz Yerlikaya , Kun Hu , Mario A. Parra , Pablo Reyes , Adolfo M. García , Diana L. Matallana , José Alberto Avila-Funes , Andrea Slachevsky , BEHRENS PELLEGRINO, MARIA ISABEL , Nilton Custodio , Juan F. Cardona , Pablo Barttfeld , Ignacio L. Brusco , Martín A. Bruno , Ana L. Sosa Ortiz , Stefanie D. Pina-Escudero , Leonel T. Takada , Elisa Resende , Katherine L. Possin , Maira Okada de Oliveira , Alejandro Lopez-Valdes , Brian Lawlor , Ian H. Robertson , Kenneth S. Kosik , Claudia Duran-Aniotz , Victor Valcour , Jennifer S. Yokoyama , Bruce Miller , Agustin Ibanez

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Frontotemporal Dementias in Latin America: History, Epidemiology, Genetics, and Clinical Research

2021 , Jorge J. Llibre-Guerra , BEHRENS PELLEGRINO, MARIA ISABEL , Mirna Lie Hosogi , Lucia Montero , Teresa Torralva , Nilton Custodio , Erika Mariana Longoria-Ibarrola , Margarita Giraldo-Chica , David Aguillón , Angela Hardi , Gladys E. Maestre , Valeria Contreras , Celeste Doldan , Lissette Duque-Peñailillo , Heike Hesse , Norbel Roman , Dhara Angelina Santana-Trinidad , Christian Schenk , Ninoska Ocampo-Barba , Ricardo López-Contreras , Ricardo Nitrini

Introduction: The historical development, frequency, and impact of frontotemporal dementia (FTD) are less clear in Latin America than in high-income countries. Although there is a growing number of dementia studies in Latin America, little is known collectively about FTD prevalence studies by country, clinical heterogeneity, risk factors, and genetics in Latin American countries.Methods: A systematic review was completed, aimed at identifying the frequency, clinical heterogeneity, and genetics studies of FTD in Latin American populations. The search strategies used a combination of standardized terms for FTD and related disorders. In addition, at least one author per Latin American country summarized the available literature. Collaborative or regional studies were reviewed during consensus meetings.Results: The first FTD reports published in Latin America were mostly case reports. The last two decades marked a substantial increase in the number of FTD research in Latin American countries. Brazil (165), Argentina (84), Colombia (26), and Chile (23) are the countries with the larger numbers of FTD published studies. Most of the research has focused on clinical and neuropsychological features (n = 247), including the local adaptation of neuropsychological and behavioral assessment batteries. However, there are little to no large studies on prevalence (n = 4), biomarkers (n = 9), or neuropathology (n = 3) of FTD.Conclusions: Future FTD studies will be required in Latin America, albeit with a greater emphasis on clinical diagnosis, genetics, biomarkers, and neuropathological studies. Regional and country-level efforts should seek better estimations of the prevalence, incidence, and economic impact of FTD syndromes.

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The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat): Driving Multicentric Research and Implementation Science

2021 , Agustin Ibanez , Jennifer S. Yokoyama , Katherine L. Possin , Diana Matallana , Francisco Lopera , Ricardo Nitrini , Leonel T. Takada , Nilton Custodio , Ana Luisa Sosa Ortiz , José Alberto Avila-Funes , BEHRENS PELLEGRINO, MARIA ISABEL , Andrea Slachevsky , Richard M. Myers , J. Nicholas Cochran , Luis Ignacio Brusco , Martin A. Bruno , Sonia M. D. Brucki , Stefanie Danielle Pina-Escudero , Maira Okada de Oliveira , Patricio Donnelly Kehoe , Adolfo M. Garcia , Juan Felipe Cardona , Hernando Santamaria-Garcia , Sebastian Moguilner , Claudia Duran-Aniotz , Enzo Tagliazucchi , Marcelo Maito , Erika Mariana Longoria Ibarrola , Maritza Pintado-Caipa , Maria Eugenia Godoy , Vera Bakman , Shireen Javandel , Kenneth S. Kosik , Victor Valcour , Bruce L. Miller

Dementia is becoming increasingly prevalent in Latin America, contrasting with stable or declining rates in North America and Europe. This scenario places unprecedented clinical, social, and economic burden upon patients, families, and health systems. The challenges prove particularly pressing for conditions with highly specific diagnostic and management demands, such as frontotemporal dementia. Here we introduce a research and networking initiative designed to tackle these ensuing hurdles, the Multi-partner consortium to expand dementia research in Latin America (ReDLat). First, we present ReDLat's regional research framework, aimed at identifying the unique genetic, social, and economic factors driving the presentation of frontotemporal dementia and Alzheimer's disease in Latin America relative to the US. We describe ongoing ReDLat studies in various fields and ongoing research extensions. Then, we introduce actions coordinated by ReDLat and the Latin America and Caribbean Consortium on Dementia (LAC-CD) to develop culturally appropriate diagnostic tools, regional visibility and capacity building, diplomatic coordination in local priority areas, and a knowledge-to-action framework toward a regional action plan. Together, these research and networking initiatives will help to establish strong cross-national bonds, support the implementation of regional dementia plans, enhance health systems' infrastructure, and increase translational research collaborations across the continent.

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Classification of Alzheimer's disease and frontotemporal dementia using routine clinical and cognitive measures across multicentric underrepresented samples: A cross sectional observational study

2023 , Marcelo Adrián Maito , Hernando Santamaría-García , Sebastián Moguilner , Katherine L. Possin , María E. Godoy , José Alberto Avila-Funes , BEHRENS PELLEGRINO, MARIA ISABEL , Ignacio L. Brusco , Martín A. Bruno , Juan F. Cardona , Nilton Custodio , Adolfo M. García , Shireen Javandel , Francisco Lopera , Diana L. Matallana , Bruce Miller , Maira Okada de Oliveira , Stefanie D. Pina-Escudero , Andrea Slachevsky , Ana L. Sosa Ortiz , Leonel T. Takada , Enzo Tagliazuchi , Victor Valcour , Jennifer S. Yokoyama , Agustín Ibañez

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Author Correction: The BrainLat project, a multimodal neuroimaging dataset of neurodegeneration from underrepresented backgrounds

2024 , Pavel Prado , Vicente Medel , Raul Gonzalez-Gomez , Agustín Sainz-Ballesteros , Victor Vidal , Hernando Santamaría-García , Sebastian Moguilner , Jhony Mejia , SLACHEVSKY CHONCHOL, ANDREA MARÍA , BEHRENS PELLEGRINO, MARIA ISABEL , David Aguillon , Francisco Lopera , Mario A. Parra , Diana Matallana , Marcelo Adrián Maito , Adolfo M. Garcia , Nilton Custodio , Alberto Ávila Funes , Stefanie Piña-Escudero , Agustina Birba , Sol Fittipaldi , Agustina Legaz , Agustín Ibañez

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Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

2024 , Sebastian Moguilner , Sandra Baez , Hernan Hernandez , Joaquín Migeot , Agustina Legaz , Raul Gonzalez-Gomez , Francesca R. Farina , Pavel Prado , Jhosmary Cuadros , Enzo Tagliazucchi , Florencia Altschuler , Marcelo Adrián Maito , María E. Godoy , Josephine Cruzat , Pedro A. Valdes-Sosa , Francisco Lopera , John Fredy Ochoa-Gómez , Alfredis Gonzalez Hernandez , Jasmin Bonilla-Santos , Rodrigo A. Gonzalez-Montealegre , Renato Anghinah , Luís E. d’Almeida Manfrinati , Sol Fittipaldi , Vicente Medel , Daniela Olivares , Görsev G. Yener , Javier Escudero , Claudio Babiloni , Robert Whelan , Bahar Güntekin , Harun Yırıkoğulları , Hernando Santamaria-Garcia , Alberto Fernández Lucas , David Huepe , Gaetano Di Caterina , Marcio Soto-Añari , Agustina Birba , Agustin Sainz-Ballesteros , Carlos Coronel-Oliveros , Amanuel Yigezu , Eduar Herrera , Daniel Abasolo , Kerry Kilborn , Nicolás Rubido , Ruaridh A. Clark , Ruben Herzog , Deniz Yerlikaya , Kun Hu , Mario A. Parra , Pablo Reyes , Adolfo M. García , Diana L. Matallana , José Alberto Avila-Funes , Andrea Slachevsky , BEHRENS PELLEGRINO, MARIA ISABEL , Nilton Custodio , Juan F. Cardona , Pablo Barttfeld , Ignacio L. Brusco , Martín A. Bruno , Ana L. Sosa Ortiz , Stefanie D. Pina-Escudero , Leonel T. Takada , Elisa Resende , Katherine L. Possin , Maira Okada de Oliveira , Alejandro Lopez-Valdes , Brian Lawlor , Ian H. Robertson , Kenneth S. Kosik , Claudia Duran-Aniotz , Victor Valcour , Jennifer S. Yokoyama , Bruce Miller , Agustin Ibanez

AbstractBrain clocks, which quantify discrepancies between brain age and chronological age, hold promise for understanding brain health and disease. However, the impact of diversity (including geographical, socioeconomic, sociodemographic, sex and neurodegeneration) on the brain-age gap is unknown. We analyzed datasets from 5,306 participants across 15 countries (7 Latin American and Caribbean countries (LAC) and 8 non-LAC countries). Based on higher-order interactions, we developed a brain-age gap deep learning architecture for functional magnetic resonance imaging (2,953) and electroencephalography (2,353). The datasets comprised healthy controls and individuals with mild cognitive impairment, Alzheimer disease and behavioral variant frontotemporal dementia. LAC models evidenced older brain ages (functional magnetic resonance imaging: mean directional error = 5.60, root mean square error (r.m.s.e.) = 11.91; electroencephalography: mean directional error = 5.34, r.m.s.e. = 9.82) associated with frontoposterior networks compared with non-LAC models. Structural socioeconomic inequality, pollution and health disparities were influential predictors of increased brain-age gaps, especially in LAC (R² = 0.37, F² = 0.59, r.m.s.e. = 6.9). An ascending brain-age gap from healthy controls to mild cognitive impairment to Alzheimer disease was found. In LAC, we observed larger brain-age gaps in females in control and Alzheimer disease groups compared with the respective males. The results were not explained by variations in signal quality, demographics or acquisition methods. These findings provide a quantitative framework capturing the diversity of accelerated brain aging.

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