ZAMORANO URRUTIA, FRANCISCO JAVIER
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ZAMORANO URRUTIA, FRANCISCO JAVIER
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franciscozamorano@udd.cl
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Scopus Author ID
57214105615

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2024 2024 2023 2023 2022 2022 2021 2021 2020 2020 2019 2019 0.0 0.0 0.5 0.5 1.0 1.0 1.5 1.5 2.0 2.0 2.5 2.5 3.0 3.0
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Interdisciplinary design process of a multi-sensory interface to facilitate learning of basic concepts of trigonometry

2019 , CORTES LOYOLA, CATALINA , ZAMORANO URRUTIA, FRANCISCO JAVIER , HERRERA MARÍN, MAURICIO RENÉ

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The parietal cortex has a causal role in ambiguity computations in humans

2024 , Gabriela Valdebenito-Oyarzo , María Paz Martínez-Molina , SOTO ICAZA, PATRICIA , Francisco Zamorano , Alejandra Figueroa-vargas , Josefina Larraín-Valenzuela , Ximena Stecher , César Salinas , Julien Bastin , Antoni Valero-Cabré , Rafael Polania , BILLEKE BOBADILLA, PABLO ERNESTO , Matthew F. S. Rushworth

Humans often face the challenge of making decisions between ambiguous options. The level of ambiguity in decision-making has been linked to activity in the parietal cortex, but its exact computational role remains elusive. To test the hypothesis that the parietal cortex plays a causal role in computing ambiguous probabilities, we conducted consecutive fMRI and TMS-EEG studies. We found that participants assigned unknown probabilities to objective probabilities, elevating the uncertainty of their decisions. Parietal cortex activity correlated with the objective degree of ambiguity and with a process that underestimates the uncertainty during decision-making. Conversely, the midcingulate cortex (MCC) encodes prediction errors and increases its connectivity with the parietal cortex during outcome processing. Disruption of the parietal activity increased the uncertainty evaluation of the options, decreasing cingulate cortex oscillations during outcome evaluation and lateral frontal oscillations related to value ambiguous probability. These results provide evidence for a causal role of the parietal cortex in computing uncertainty during ambiguous decisions made by humans.

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Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis

2024 , Cassandra M J Wannan , Barnaby Nelson , Jean Addington , Kelly Allott , Alan Anticevic , Celso Arango , Justin T Baker , Carrie E Bearden , Tashrif Billah , Sylvain Bouix , Matthew R Broome , Kate Buccilli , Kristin S Cadenhead , Monica E Calkins , Tyrone D Cannon , Guillermo Cecci , Eric Yu Hai Chen , Kang Ik K Cho , Jimmy Choi , Scott R Clark , Michael J Coleman , Philippe Conus , Cheryl M Corcoran , Barbara A Cornblatt , Covadonga M Diaz-Caneja , Dominic Dwyer , Bjørn H Ebdrup , Lauren M Ellman , Paolo Fusar-Poli , Liliana Galindo , Pablo A Gaspar , Carla Gerber , Louise Birkedal Glenthøj , Robert Glynn , Michael P Harms , Leslie E Horton , René S Kahn , Joseph Kambeitz , Lana Kambeitz-Ilankovic , John M Kane , Tina Kapur , Matcheri S Keshavan , Sung-Wan Kim , Nikolaos Koutsouleris , Marek Kubicki , Jun Soo Kwon , Kerstin Langbein , Kathryn E Lewandowski , Gregory A Light , Daniel Mamah , Patricia J Marcy , Daniel H Mathalon , Patrick D McGorry , Vijay A Mittal , Merete Nordentoft , Angela Nunez , Ofer Pasternak , Godfrey D Pearlson , Jesus Perez , Diana O Perkins , Albert R Powers , David R Roalf , Fred W Sabb , Jason Schiffman , Jai L Shah , Stefan Smesny , Jessica Spark , William S Stone , Gregory P Strauss , Zailyn Tamayo , John Torous , Rachel Upthegrove , Mark Vangel , Swapna Verma , Jijun Wang , Inge Winter-van Rossum , Daniel H Wolf , Phillip Wolff , Stephen J Wood , Alison R Yung , Carla Agurto , Mario Alvarez-Jimenez , Paul Amminger , Marco Armando , Ameneh Asgari-Targhi , John Cahill , Ricardo E Carrión , Eduardo Castro , Suheyla Cetin-Karayumak , M Mallar Chakravarty , Youngsun T Cho , David Cotter , Simon D’Alfonso , Michaela Ennis , Shreyas Fadnavis , Clara Fonteneau , Caroline Gao , Tina Gupta , Raquel E Gur , Ruben C Gur , Holly K Hamilton , Gil D Hoftman , Grace R Jacobs , Johanna Jarcho , Jie Lisa Ji , Christian G Kohler , Paris Alexandros Lalousis , Suzie Lavoie , Martin Lepage , Einat Liebenthal , Josh Mervis , Vishnu Murty , Spero C Nicholas , Lipeng Ning , Nora Penzel , Russell Poldrack , Pablo Polosecki , Danielle N Pratt , Rachel Rabin , Habiballah Rahimi Eichi , Yogesh Rathi , Avraham Reichenberg , Jenna Reinen , Jack Rogers , Bernalyn Ruiz-Yu , Isabelle Scott , Johanna Seitz-Holland , Vinod H Srihari , Agrima Srivastava , Andrew Thompson , Bruce I Turetsky , Barbara C Walsh , Thomas Whitford , Johanna T W Wigman , Beier Yao , Hok Pan Yuen , Uzair Ahmed , Andrew (Jin Soo) Byun , Yoonho Chung , Kim Do , Larry Hendricks , Kevin Huynh , Clark Jeffries , Erlend Lane , Carsten Langholm , Eric Lin , Valentina Mantua , Gennarina Santorelli , Kosha Ruparel , Eirini Zoupou , Tatiana Adasme , Lauren Addamo , Laura Adery , Munaza Ali , Andrea Auther , Samantha Aversa , Seon-Hwa Baek , Kelly Bates , Alyssa Bathery , Johanna M M Bayer , Rebecca Beedham , Zarina Bilgrami , Sonia Birch , Ilaria Bonoldi , Owen Borders , Renato Borgatti , Lisa Brown , Alejandro Bruna , Holly Carrington , Rolando I Castillo-Passi , Justine Chen , Nicholas Cheng , Ann Ee Ching , Chloe Clifford , Beau-Luke Colton , Pamela Contreras , Sebastián Corral , Stefano Damiani , Monica Done , Andrés Estradé , Brandon Asika Etuka , Melanie Formica , Rachel Furlan , Mia Geljic , Carmela Germano , Ruth Getachew , Mathias Goncalves , Anastasia Haidar , Jessica Hartmann , Anna Jo , Omar John , Sarah Kerins , Melissa Kerr , Irena Kesselring , Honey Kim , Nicholas Kim , Kyle Kinney , Marija Krcmar , Elana Kotler , Melanie Lafanechere , Clarice Lee , Joshua Llerena , Christopher Markiewicz , Priya Matnejl , Alejandro Maturana , Aissata Mavambu , Rocío Mayol-Troncoso , Amelia McDonnell , Alessia McGowan , Danielle McLaughlin , Rebecca McIlhenny , Brittany McQueen , Yohannes Mebrahtu , Martina Mensi , Christy Lai Ming Hui , Yi Nam Suen , Stephanie Ming Yin Wong , Neal Morrell , Mariam Omar , Alice Partridge , Christina Phassouliotis , Anna Pichiecchio , Pierluigi Politi , Christian Porter , Umberto Provenzani , Nicholas Prunier , Jasmine Raj , Susan Ray , Victoria Rayner , Manuel Reyes , Kate Reynolds , Sage Rush , Cesar Salinas , Jashmina Shetty , Callum Snowball , Sophie Tod , Gabriel Turra-Fariña , Daniela Valle , Simone Veale , Sarah Whitson , Alana Wickham , Sarah Youn , Francisco Zamorano , Elissa Zavaglia , Jamie Zinberg , Scott W Woods , Martha E Shenton

Abstract This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.

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Design of a multisensory interface that explores human-technology interaction to facilitate the learning of basic trigonometry concepts

2024 , ZAMORANO URRUTIA, FRANCISCO JAVIER , CORTES LOYOLA, CATALINA , HERRERA MARÍN, MAURICIO RENÉ

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A Tangible User Interface to Facilitate Learning of Trigonometry

2019 , ZAMORANO URRUTIA, FRANCISCO JAVIER , CORTES LOYOLA, CATALINA , HERRERA MARÍN, MAURICIO RENÉ

In mathematics education, studies reveal difficulties in the teaching-learning of trigonometry in secondary and higher education, due to the fact that students are not encouraged to achieve a deep conceptual understanding of abstract concepts. Several studies demonstrate that incorporating digital technologies has a positive impact on students’ learning. However, most of the existing technologies do not consider the use of the body and multiple senses. Tangible User Interfaces (TUIs) in contrast, can host bodily interactions that have the potential of enhancing learning. Nonetheless, there is a lack of applications of TUIs for trigonometry education. This study consisted in designing and validating a tangible interface for the teaching-learning of basic concepts of trigonometry. The interface hosts a pedagogical experience that privileges exploration through physical manipulation and fosters intuitive and collaborative learning. A Pre-Test was applied to 121 students to determine previous knowledge, yielding a 29.1% performance. After two sessions using the interface, the results of a Post-Test reveal an increase of 37.1%, confirming the educational effectiveness of the interface and the pedagogical experience to facilitate learning of basic concepts of trigonometry.

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Designing an intuitive interface to enhance trigonometry learning

2019 , ZAMORANO URRUTIA, FRANCISCO JAVIER , CORTES LOYOLA, CATALINA , HERRERA MARÍN, MAURICIO RENÉ

In the last three decades, the application of TUIs (tangible user interfaces) in education has demonstrated its positive influence on performance and learning of students. At Universidad del Desarrollo in Chile, monitoring of diagnostic tests over time evidences difficulties and challenges in the teaching-learning of trigonometry in first-year Engineering education. This study consisted in designing and validating a tangible interface to learn trigonometry in the classroom setting. The methodology used was a quasi-experiment with first-year students from the Schools of Design and Engineering at Universidad del Desarrollo in Chile. Principles of the theory of Embodied Cognition and Blended Interaction were applied to model an intuitive, collaborative and meaningful learning experience. During the design process, three Intermediate Models were tested with several types of users, and two Prototypes were tested with an experimental group. User-testing highly contributed to the design of the interaction experience and the interface, progressively defining the functional and pedagogical aspects. Comparative analysis of Pre and Post-Test results, demonstrate that students’ performance increased by 37.1% after two sessions using the interface.

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Facilitando el aprendizaje de trigonometría a través de una interfaz tangible

2020 , ZAMORANO URRUTIA, FRANCISCO JAVIER , CORTES LOYOLA, CATALINA , HERRERA MARÍN, MAURICIO RENÉ

En educación matemática, estudios evidencian dificultades y desafíos en la enseñanza-aprendizaje de trigonometría en educación secundaria y superior, donde no se estimula al estudiante a obtener un entendimiento conceptual profundo de los conceptos. Considerando su relevancia para diversas disciplinas, es necesario implementar nuevos acercamientos a su enseñanza, donde se privilegie un rol activo del estudiante en su propio aprendizaje. Diversos estudios demuestran que la incorporación de tecnologías digitales influyen positivamente aprendizaje de los alumnos, sin embargo, la mayoría de las tecnologías existentes responden al paradigma de interacción tradicional con un computador, donde no se considera el uso del cuerpo y de los múltiples sentidos. Las Interfaces Tangibles (TUI) en cambio, pueden albergar interacciones corporales, brindando directo tributo a la teoría de la Cognición Corporal. Sin embargo existe un vacío en la aplicación de TUI para la educación de trigonometría. Esta investigación consistió en diseñar y validar una interfaz tangible para la enseñanza-aprendizaje de trigonometría inicial. La interfaz alberga una experiencia de aprendizaje que privilegia la exploración, el uso de la intuición, y fomenta el aprendizaje colaborativo. Se realizó un Pre-Test diagnóstico con 119 estudiantes para determinar conocimientos previos dando un rendimiento promedio de 29.1%. Luego de dos intervenciones con la interfaz propuesta, los resultados de un Post-Test muestran un incremento del rendimiento en un 37.1%, lo que valida la efectividad pedagógica de la interfaz y experiencia pedagógica para el aprendizaje de conceptos básicos de trigonometría.

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Functional Dizziness as a Spatial Cognitive Dysfunction

2023 , Hayo Breinbauer , Camilo Arévalo-Romero , Karen Villarroel , Claudio Lavin , Felipe Faúndez , Rosario Garrido , Kevin Alarcón , STECHER GUZMAN, XIMENA PATRICIA , ZAMORANO URRUTIA, FRANCISCO JAVIER , BILLEKE BOBADILLA, PABLO ERNESTO , Paul H. Delano

(1) Background: Persistent postural-perceptual dizziness (PPPD) is a common chronic dizziness disorder with an unclear pathophysiology. It is hypothesized that PPPD may involve disrupted spatial cognition processes as a core feature. (2) Methods: A cohort of 19 PPPD patients underwent psycho-cognitive testing, including assessments for anxiety, depression, memory, attention, planning, and executive functions, with an emphasis on spatial navigation via a virtual Morris water maze. These patients were compared with 12 healthy controls and 20 individuals with other vestibular disorders but without PPPD. Vestibular function was evaluated using video head impulse testing and vestibular evoked myogenic potentials, while brain magnetic resonance imaging was used to exclude confounding pathology. (3) Results: PPPD patients demonstrated unique impairments in allocentric spatial navigation (as evidenced by the virtual Morris water maze) and in other high-demand visuospatial cognitive tasks that involve executive functions and planning, such as the Towers of London and Trail Making B tests. A factor analysis highlighted spatial navigation and advanced visuospatial functions as being central to PPPD, with a strong correlation to symptom severity. (4) Conclusions: PPPD may broadly impair higher cognitive functions, especially in spatial cognition. We discuss a disruption in the creation of enriched cognitive spatial maps as a possible pathophysiology for PPPD.

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Design of an eOSCE for the Chilean Healthcare Context

2022 , ZAMORANO URRUTIA, FRANCISCO JAVIER , Mauricio Reyes , Germán Espinoza , REYES ARAMBURU, EDISON PABLO

Objective Structured Clinical Examination (OSCE) is the standard to assess and train clinical skills in healthcare students. However, conducting an OSCE demands expensive resources such as time, qualified personnel, and adequate facilities. The aim to provide more cost-effective examinations has promoted the emergence of electronic versions of OSCEs (eOSCEs). However, existing eOSCEs available in the market do not adequately adapt to diverse local contexts. For a Spanish-speaking country such as Chile, implementing foreign eOSCEs requires to adjust the examination to unfamiliar terminology, archetypes, and procedures, thus hindering the quality of the assessment. This article reports on the design of Ch-eOSCE, an eOSCE tailored for the Chilean local context and culture. Ch-eOSCE is comprised of a mobile application and a back-end system. A prototype of the application was developed and tested with three healthcare experts to gather their perception of usability and coherence, yielding an overall evaluation of 4.5 in a scale range of 5. The preliminary results reveal that Ch-eOSCE has the potential to become a viable solution for a context-specific eOSCE for the Chilean healthcare context.

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