IRURETAGOYENA, BARBARA

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Functional Dysconnectivity in Ventral Striatocortical Systems in 22q11.2 Deletion Syndrome
(2021)
Ángeles Tepper
;
Analía Cuiza
;
Luz María Alliende
;
Carlos Mena
;
Juan Pablo Ramirez-Mahaluf
<jats:title>Abstract</jats:title> <jats:p>22q11.2 deletion syndrome (22q11.2DS) is a genetic neurodevelopmental disorder that represents one of the greatest known risk factors for psychosis. Previous studies in psychotic subjects without the deletion have identified a dopaminergic dysfunction in striatal regions, and dysconnectivity of striatocortical systems, as an important mechanism in the emergence of psychosis. Here, we used resting-state functional MRI to examine striatocortical functional connectivity in 22q11.2DS patients. We used a 2 × 2 factorial design including 125 subjects (55 healthy controls, 28 22q11.2DS patients without a history of psychosis, 10 22q11.2DS patients with a history of psychosis, and 32 subjects with a history of psychosis without the deletion), allowing us to identify network effects related to the deletion and to the presence of psychosis. In line with previous results from psychotic patients without 22q11.2DS, we found that there was a dorsal to ventral gradient of hypo- to hyperstriatocortical connectivity related to psychosis across both patient groups. The 22q11.2DS was additionally associated with abnormal functional connectivity in ventral striatocortical networks, with no significant differences identified in the dorsal system. Abnormalities in the ventral striatocortical system observed in these individuals with high genetic risk to psychosis may thus reflect a marker of illness risk.</jats:p>
1Scopus© Citations 6
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Anti-stigma advocacy for health professionals: a systematic review
(2023)
Zoe Guerrero
;
Barbara Iruretagoyena
;
Sarah Parry
;
Claire Henderson
14Scopus© Citations 33
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Predictors of clozapine discontinuation at 2 years in treatment-resistant schizophrenia
(2021)
Barbara Iruretagoyena
;
Carmen Paz Castañeda
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Cristian Mena
;
Camila Diaz
;
Ruben Nachar
7Scopus© Citations 10
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Gender, age and geographical representation over the past 50 years of schizophrenia research
(2022)
Luz María Alliende
;
Leticia S. Czepielewski
;
David Aceituno
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Carmen Paz Castañeda
;
Camila Diaz
15Scopus© Citations 5
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Early treatment resistance in a Latin-American cohort of patients with schizophrenia
(2018)
Cristian Mena
;
Alfonso Gonzalez-Valderrama
;
Barbara Iruretagoyena
;
Juan Undurraga
;
Nicolas A. Crossley
Scopus© Citations 11 1
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High prevalence of metabolic alterations in Latin American patients at initial stages of psychosis
(2019)
Barbara Iruretagoyena
;
Carmen P. Castañeda
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UNDURRAGA FOURCADE, JUAN PABLO
;
Rubén Nachar
;
Cristian Mena
Scopus© Citations 5 2
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The incidence of non-affective psychotic disorders in Chile between 2005 and 2018: results from a national register of over 30 000 cases
(2020)
Alfonso González-Valderrama
;
Hannah E. Jongsma
;
Cristián Mena
;
Carmen Paz Castañeda
;
Rubén Nachar
<jats:title>Abstract</jats:title><jats:sec id="S0033291720002664_sec_a1"><jats:title>Background</jats:title><jats:p>Evidence suggests the incidence of non-affective psychotic disorders (NAPDs) varies across persons and places, but data from the Global South is scarce. We aimed to estimate the treated incidence of NAPD in Chile, and variance by person, place and time.</jats:p></jats:sec><jats:sec id="S0033291720002664_sec_a2" sec-type="methods"><jats:title>Methods</jats:title><jats:p>We used national register data from Chile including all people, 10–65 years, with the first episode of NAPD (<jats:italic>International Classification of Diseases, Tenth Revision:</jats:italic> F20–F29) between 1 January 2005 and 29 August 2018. Denominators were estimated from Chilean National Census data. Our main outcome was treated incidence of NAPD and age group, sex, calendar year and regional-level population density, multidimensional poverty and latitude were exposures of interest.</jats:p></jats:sec><jats:sec id="S0033291720002664_sec_a3" sec-type="results"><jats:title>Results</jats:title><jats:p>We identified 32 358 NAPD cases [12 136 (39.5%) women; median age-at-first-contact: 24 years (interquartile range 18–39 years)] during 171.1 million person-years [crude incidence: 18.9 per 100 000 person-years; 95% confidence interval (CI) 18.7–19.1]. Multilevel Poisson regression identified a strong age–sex interaction in incidence, with rates peaking in men (57.6 per 100 000 person-years; 95% CI 56.0–59.2) and women (29.5 per 100 000 person-years; 95% CI 28.4–30.7) between 15 and 19 years old. Rates also decreased (non-linearly) over time for women, but not men. We observed a non-linear association with multidimensional poverty and latitude, with the highest rates in the poorest regions and those immediately south of Santiago; no association with regional population density was observed.</jats:p></jats:sec><jats:sec id="S0033291720002664_sec_a4" sec-type="conclusions"><jats:title>Conclusion</jats:title><jats:p>Our findings inform the aetiology of NAPDs, replicating typical associations with age, sex and multidimensional poverty in a Global South context. The absence of association with population density suggests this risk may be context-dependent.</jats:p></jats:sec>
Scopus© Citations 8 1
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The enduring gap in educational attainment in schizophrenia according to the past 50 years of published research: a systematic review and meta-analysis
(2022)
Barbara Iruretagoyena
;
UNDURRAGA FOURCADE, JUAN PABLO
14

IRURETAGOYENA, BARBARA

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