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    Scopus© Citations 20  1
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    Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after transplantation into adult unconditioned mice
    (2004-08-27)
    Allers, Carolina
    ;
    Sierralta, Walter D.
    ;
    Neubauer, Sonia
    ;
    Rivera, Francisco
    ;
    Minguell, José J.
    Background. The use of mesenchymal stem cells (MSC) for cell therapy relies on their capacity to engraft and survive long term in the appropriate target tissue(s). Animal models have demonstrated that the syngeneic or xenogeneic transplantation of MSC results in donor engraftment into the bone marrow and other tissues of conditioned recipients. However, there are no reliable data showing the fate of human MSC infused into conditioned or unconditioned adult recipients. Methods. In the present study, the authors investigated, by using imaging, polymerase chain reaction (PCR), and in situ hybridization, the biodistribution of human bone marrow-derived MSC after intravenous infusion into unconditioned adult nude mice. Results. As assessed by imaging (gamma camera), PCR, and in situ hybridization analysis, the authors' results demonstrate the presence of human MSC in bone marrow, spleen, and mesenchymal tissues of recipient mice. Conclusions. These results suggest that human MSC transplantation into unconditioned recipients represents an option for providing cellular therapy and avoids the complications associated with drugs or radiation conditioning.
      1Scopus© Citations 143  1
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    Treatment of Meniscal Deficiency with Meniscal Allograft Transplantation and Femoral Osteotomy in a Patient with History of Lateral Discoid Meniscus
    (2020)
    Stefano Zaffagnini
    ;
    Maximiliano Espinosa
    ;
    Maria Pia Neri
    ;
    Maurilio Marcacci
    ;
    Alberto Grassi
      20Scopus© Citations 7
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    Meniscus allograft transplantation: indications, techniques and outcomes
    (2019)
    FIGUEROA BERRIOS, FRANCISCO JAVIER  
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    FIGUEROA POBLETE, DAVID HUMBERTO  
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    CALVO RODRIGUEZ, RAFAEL  
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    Alex Vaisman  
    ;
    João Espregueira-Mendes
    <jats:p> New indications for meniscal allograft transplantation (MAT) are being added, but the general expert opinion is that it is still a procedure reserved for symptomatic meniscal loss. Lateral MAT has better clinical outcomes and less failure risk compared to medial MAT. Ideal conditions (low-grade chondral lesions) make MAT a more survivable and successful procedure. Meniscal extrusion after MAT is common and does not seem to alter results. Midterm survivorship of a MAT is reported to be 85–90%, while long-term survivorship decreases to 50–70% depending on chondral status and concomitant procedures. Even if the procedure is a success, there are high possibilities of not being able to resume sports activities. </jats:p><jats:p> Cite this article: EFORT Open Rev 2019;4:115-120. DOI: 10.1302/2058-5241.4.180052 </jats:p>
      2Scopus© Citations 55
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    Scopus© Citations 3  1
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      22Scopus© Citations 3
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    High-Grade Patellar Chondral Defects: Promising Results From Management With Osteochondral Autografts
    (2020)
    FIGUEROA POBLETE, DAVID HUMBERTO  
    ;
    CALVO RODRIGUEZ, RAFAEL  
    ;
    Rodrigo Donoso
    ;
    Jaime Espinoza
    ;
    Alex Vaisman  
    <jats:sec><jats:title>Background:</jats:title><jats:p>Patellar chondral defects represent up to 34.6% of defects found during routine arthroscopy. Surgical management has evolved during the past 20 years in an effort to develop techniques to replace hyaline cartilage. Currently, the only technique that achieves this is osteochondral autologous transfer (OAT). Although good and excellent results have often been reported at midterm and long-term follow-up for femoral lesions, little is known about isolated patellar defects.</jats:p></jats:sec><jats:sec><jats:title>Purpose:</jats:title><jats:p>To assess clinical and imaging results of patients treated with OAT for high-grade patellar defects.</jats:p></jats:sec><jats:sec><jats:title>Study Design:</jats:title><jats:p>Case series; Level of evidence, 4.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>This was a retrospective study on all patients who received OAT for high-grade symptomatic patellar chondral defects between 2010 and 2018 at our institution. The study included patients younger than 40 years of age with anterior knee pain and a grade 4 International Cartilage Repair Society patellar chondral defect between 1 and 2.5 cm<jats:sup>2</jats:sup>. Patients with surgery in other knee compartments, concomitant anterior cruciate ligament ruptures, infection, rheumatoid arthritis, and degenerative lesions were excluded. Six months postoperatively, all patients underwent magnetic resonance imaging (MRI) to allow assessment of graft integrity via the MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) score to evaluate morphologic features and integration. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Kujala scores were used to assess functional outcomes at final follow-up.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>A total of 26 patients who received a patellar OAT were included. Most patients were male (88.4%), and the mean ± SD age was 28.5 ± 9.7 years. Patellar chondral defects had a median size of 180 mm<jats:sup>2</jats:sup>(range, 64-250 mm<jats:sup>2</jats:sup>), and patients received a median of 1 autograft (range, 1-3). Functional outcomes assessed at a minimum of 1 year after surgery showed a mean Kujala score of 90.42 ± 6.7 and a mean WOMAC score of 95 ± 3.6. MRI revealed a median MOCART score of 75 points (range, 20-90 points).</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>To our knowledge, this is the largest series to date regarding isolated patellar OAT. At midterm follow-up, most patients reported good and excellent results regarding symptoms and activity levels. Most autografts showed good osseous integration and excellent filling of the chondral surface, as evidenced on MRI. OAT is a good alternative to treat high-grade patellar chondral defects, especially among young patients.</jats:p></jats:sec>
    Scopus© Citations 11  1
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    Osteochondral Autologous Transplantation for Treating Patellar High-Grade Chondral Defects: A Systematic Review
    (2019)
    Rodrigo Donoso
    ;
    DAVID HUMBERTO FIGUEROA POBLETE
    ;
    Jaime Espinoza
    ;
    Claudio Yañez
    ;
    Jamil Saavedra
    <jats:sec><jats:title>Background:</jats:title><jats:p>Patellar cartilage defects account for 34.6% of defects found during routine arthroscopy. These defects pose a challenge in orthopaedic surgery because they have been associated with worse outcomes after surgical repair compared with other chondral lesions within the knee.</jats:p></jats:sec><jats:sec><jats:title>Purpose:</jats:title><jats:p>To systematically review the literature for evidence on results of osteochondral autologous transplantation (OAT) for the management of isolated patellar cartilage high-grade defects (International Cartilage Repair Society [ICRS] grade 3-4).</jats:p></jats:sec><jats:sec><jats:title>Study Design:</jats:title><jats:p>Systematic review; Level of evidence, 4.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>A systematic review of the literature was performed to find studies that addressed outcomes regarding OAT to treat patellar high-grade cartilage defects (ICRS grade 3-4). Studies addressing patient-reported outcomes, return to sports, or magnetic resonance imaging (MRI) at follow-up after isolated OAT procedures for patellar cartilage defects were included.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>A total of 5 studies were included in this review. We were not able to perform a meta-analysis as no studies had available data. A total of 102 patients who received an isolated OAT for a patellar chondral defect were included in these 5 studies. All patients showed significant improvement at final follow-up based on the following patient-reported outcome scores: Lysholm, International Knee Documentation Committee, Kujala, Tegner, and 36-Item Short Form Health Survey. We found that 4 studies used MRI during the first postoperative year to assess osteochondral plug integration and positioning. The results demonstrated that most plugs were integrated and correctly positioned when evaluated at follow-up, conducted on average after 12 months. Whether patients were able to return to sports was queried in 2 of the included studies, revealing that patients could return to their previous level in most cases (Tegner score, 5-9 at 2 years after surgery).</jats:p></jats:sec><jats:sec><jats:title>Conclusion:</jats:title><jats:p>Results indicate that OAT is a safe and reliable technique to treat patellar high-grade osteochondral defects, allowing for significant improvement in patient-reported outcomes and return to sports.</jats:p></jats:sec>
      1Scopus© Citations 24
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    The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice
    (2017)
    Tomas de Mayo
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    CONGET MOLINA, PAULETTE ANDREA  
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    Silvia Becerra-Bayona
    ;
    Claudia L. Sossa
    ;
    Virgilio Galvis
    Scopus© Citations 65  6
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      1Scopus© Citations 60  5