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Regenerative Potential of Mesenchymal Stromal Cells: Age-Related Changes
(2016)
FLAVIA ALEJANDRA BRUNA
;
CONTADOR MARTINEZ, DAVID ERNESTO
;
CONGET MOLINA, PAULETTE ANDREA
;
Benjamín Erranz
;
Claudia L. Sossa
<jats:p>Preclinical and clinical studies have shown that a therapeutic effect results from mesenchymal stromal cells (MSCs) transplant. No systematic information is currently available regarding whether donor age modifies MSC regenerative potential on cutaneous wound healing. Here, we evaluate whether donor age influences this potential. Two different doses of bone marrow MSCs (BM-MSCs) from young, adult, or old mouse donors or two doses of their acellular derivatives mesenchymal stromal cells (acd-MSCs) were intradermally injected around wounds in the midline of C57BL/6 mice. Every two days, wound healing was macroscopically assessed (wound closure) and microscopically assessed (reepithelialization, dermal-epidermal junction, skin appendage regeneration, granulation tissue, leukocyte infiltration, and density dermal collagen fibers) after 12 days from MSC transplant. Significant differences in the wound closure kinetic, quality, and healing of skin regenerated were observed in lesions which received BM-MSCs from different ages or their acd-MSCs compared to lesions which received vehicle. Nevertheless, our data shows that adult’s BM-MSCs or their acd-MSCs were the most efficient for recovery of most parameters analyzed. Our data suggest that MSC efficacy was negatively affected by donor age, where the treatment with adult’s BM-MSCs or their acd-MSCs in cutaneous wound promotes a better tissue repair/regeneration. This is due to their paracrine factors secretion.</jats:p>
1Scopus© Citations 41 1
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Transcriptomic Analysis of Mouse Cochlear Supporting Cell Maturation Reveals Large-Scale Changes in Notch Responsiveness Prior to the Onset of Hearing
(2016)
Juan C. Maass
;
Rende Gu
;
Tiantian Cai
;
Ying-Wooi Wan
;
Silvia C. Cantellano
7Scopus© Citations 41
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The role of bone marrow mesenchymal stromal cell derivatives in skin wound healing in diabetic mice
(2017)
Tomas de Mayo
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CONGET MOLINA, PAULETTE ANDREA
;
Silvia Becerra-Bayona
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Claudia L. Sossa
;
Virgilio Galvis
Scopus© Citations 65 6
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Comparative study of the neural differentiation capacity of mesenchymal stromal cells from different tissue sources: An approach for their use in neural regeneration therapies
(2019)
Daniela N. Urrutia
;
Pablo Caviedes
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Rodrigo Mardones
;
José J. Minguell
;
ANA MARIA FERNANDA VEGA LETTER
27Scopus© Citations 103
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Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
(2019)
Esther Hoste
;
Christian Maueröder
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Lisette van Hove
;
Leen Catrysse
;
Hanna-Kaisa Vikkula
17Scopus© Citations 66
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Arthroscopic Intercondylar Notch Bone Marrow Aspiration During Anterior Cruciate Ligament Reconstruction
(2019)
David Limo Figueroa
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CALVO RODRIGUEZ, RAFAEL
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VAISMAN BURUCKER, ALEJANDRO ESTEBAN
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Sergio Arellano
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FIGUEROA BERRIOS, FRANCISCO JAVIER
13Scopus© Citations 4

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