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Pan American League of Associations for Rheumatology recommendations for the management of axial spondyloarthritis
(2023)
Wilson Bautista-Molano
;
Daniel G. Fernández-Ávila
;
María Lorena Brance
;
María Gabriela Ávila Pedretti
;
Ruben Burgos-Vargas
3Scopus© Citations 45
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De-escalating therapy in inflammatory bowel disease: Results from an observational study in clinical practice
(2023)
Alex Aren
;
María José Moreta
;
Ingrid Ordás
;
Agnès Fernández-Clotet
;
Berta Caballol
1Scopus© Citations 1
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miRNA Landscape in Pathogenesis and Treatment of Vogt–Koyanagi–Harada Disease
(2021)
Fabian Vega-Tapia
;
Mario Bustamante
;
Rodrigo A. Valenzuela
;
Cristhian A. Urzua
;
Loreto Cuitino
<jats:p>miRNAs, one of the members of the noncoding RNA family, are regulators of gene expression in inflammatory and autoimmune diseases. Changes in miRNA pool expression have been associated with differentiation of CD4<jats:sup>+</jats:sup> T cells toward an inflammatory phenotype and with loss of self-tolerance in autoimmune diseases. Vogt–Koyanagi–Harada (VKH) disease is a chronic multisystemic pathology, affecting the uvea, inner ear, central nervous system, and skin. Several lines of evidence support an autoimmune etiology for VKH, with loss of tolerance against retinal pigmented epithelium-related self-antigens. This deleterious reaction is characterized by exacerbated inflammation, due to an aberrant T<jats:sub><jats:italic>H</jats:italic></jats:sub>1 and T<jats:sub><jats:italic>H</jats:italic></jats:sub>17 polarization and secretion of their proinflammatory hallmark cytokines interleukin 6 (IL-6), IL-17, interferon γ, and tumor necrosis factor α, and an impaired CD4<jats:sup>+</jats:sup> CD25<jats:sup><jats:italic>high</jats:italic></jats:sup> FoxP3<jats:sup>+</jats:sup> regulatory T cell function. To restrain inflammation, VKH is pharmacologically treated with corticosteroids and immunosuppressive drugs as first and second line of therapy, respectively. Changes in the expression of miRNAs related to immunoregulatory pathways have been associated with VKH development, whereas some genetic variants of miRNAs have been found to be risk modifiers of VKH. Furthermore, the drugs commonly used in VKH treatment have great influence on miRNA expression, including those miRNAs associated to VKH disease. This relationship between response to therapy and miRNA regulation suggests that these small noncoding molecules might be therapeutic targets for the development of more effective and specific pharmacological therapy for VKH. In this review, we discuss the latest evidence regarding regulation and alteration of miRNA associated with VKH disease and its treatment.</jats:p>
4Scopus© Citations 7
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Refractory systemic juvenile idiopathic arthritis successfully treated with rapamycin
(2021)
Sara Concha
;
Emma Rey-Jurado
;
M Cecilia Poli
;
Rodrigo Hoyos-Bachiloglu
;
Arturo Borzutzky
Scopus© Citations 6 1
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Approach to the Patient with Axial Spondyloarthritis and Suspected Inflammatory Bowel Disease
(2020)
IBAÑEZ, SEBASTIAN
;
María Paz Poblete De La Fuente
;
Elisa Catalina Parra Cancino
3 1Scopus© Citations 2
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Current knowledge of immunosuppression as a risk factor for skin cancer development
(2022)
ROLLAN MARZOLO, MARIA PAZ
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CABRERA MORAGA, RAUL ALEJANDRO
;
Robert A. Schwartz
Scopus© Citations 18 5
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Diagnosis and classification of optic neuritis
(2022)
Axel Petzold
;
Clare L Fraser
;
Mathias Abegg
;
Raed Alroughani
;
Daniah Alshowaeir
Scopus© Citations 81 2
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International eDelphi Study to Reach Consensus on the Methotrexate Dosing Regimen in Patients With Psoriasis
(2022)
Astrid M. van Huizen
;
Stef P. Menting
;
Rolland Gyulai
;
Lars Iversen
;
Gayle E. van der Kraaij
40Scopus© Citations 19
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Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs
(2021)
Silva González, Alvaro
;
Rafael Llombart-Blanco
;
Gallegos Angulo, Marcela
;
Carlos Villas Tomé
;
Matías Alfonso Olmos-García
<jats:sec><jats:title>Study Design:</jats:title><jats:p> Animal experimental model. </jats:p></jats:sec><jats:sec><jats:title>Objective:</jats:title><jats:p> To study the clinical behavior and histological changes in the spinal cord, nerve roots and perivertebral muscles of the spine after induced leakage of polymethylmethacrylate (PMMA) loaded with antiblastic drugs during vertebroplasty in an animal model of pigs. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> We performed vertebroplasty on 25 pigs. The animals were divided into 3 groups: vertebroplasty with PMMA alone (control group), vertebroplasty with PMMA loaded with methotrexate (MTX) and vertebroplasty with PMMA loaded with cisplatin (CYS). At 2 vertebral levels, epidural and prevertebral, massive cement leaks were induced. Animals were evaluated daily. Two weeks later, the pigs were sacrificed, and the tissues that came in contact with the cement were analyzed. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> The clinical results for each of the groups were reported. The control group had no clinical alterations. In the MTX group, 2 pigs died before 1 week due to pneumonitis. In the CYS group, 4 animals had motor impairment, and 3 of the 4 had paraplegia. The histological results were as follows: the control and MTX groups showed synovial metaplasia, inflammatory reaction, crystal deposits, and giant cell reaction in the dura mater and muscle and all the animals in the CYS group had spinal cord and muscular necrosis. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> Massive cement leak after vertebroplasty with PMMA loaded with cisplatin is extremely toxic to the spinal cord and muscles around the spine. Therefore, its use cannot be recommended for the treatment of vertebral metastases. Using PMMA loaded with methotrexate seems to be a safe procedure, but further research is needed. </jats:p></jats:sec>
6Scopus© Citations 4
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New Pharmacological Strategies for the Treatment of Non-Infectious Uveitis. A Minireview
(2020)
Rodrigo A. Valenzuela
;
Iván Flores
;
Beatriz Urrutia
;
Francisca Fuentes
;
Pablo E. Sabat
Scopus© Citations 28 2

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