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Item type:Publication, Lack of treatment options for endemic helminth infections in Chile affects patient care and public health(Elsevier BV, 2025-06); 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lives lost and disease burden related to antimicrobial resistance in the Americas can no longer be ignored(2023)2Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Highly active antiretroviral therapy discontinuation time is associated with therapeutic failure among human immunodeficiency virus (<scp>HIV</scp>)‐infected immigrant adults: A cohort study from a Peruvian referral hospital during the Venezuelan exodus(2023); Alfonso J. Rodriguez‐Morales<jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To evaluate the association between Highly Active Antiretroviral Therapy (HAART) discontinuation time and therapeutic failure (TF) in Venezuelan immigrants with HIV that restart HAART.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We carried out a retrospective cohort study in a large hospital in Peru. We included Venezuelan immigrants who restarted HAART and were followed over at least 6 months. The primary outcome was TF. Secondary outcomes were immunologic (IF), virologic (VF) and clinical (CF) failures. The exposure variable was HAART discontinuation, categorised as no discontinuation, less than 6 months, and 6 months or more. We applied generalised linear models Poisson family with robust standard errors to calculate crude (cRR) and adjusted (aRR) relative risks by statistical and epidemiological criteria.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We included 294 patients, 97.2% were males, and the median age was 32 years. Out of all the patients, 32.7% discontinued HAART for less than 6 months, 15.0% discontinued for more than 6 months and the remaining 52.3% did not discontinue. The cumulative incidence of TF was 27.9%, 24.5% in VF, 6.0% in IF and 6.0% in CF. Compared with non‐discontinued HAART patients, the discontinuation for less than 6 months (aRR = 1.98 [95% CI: 1.27<jats:bold>–</jats:bold>3.09]) and from 6 months to more (aRR = 3.17 [95% CI: 2.02<jats:bold>–</jats:bold>4.95]) increased the risk of TF. Likewise, treatment discontinuation of up to 6 months (aRR = 2.32 [95% CI: 1.40<jats:bold>–</jats:bold>3.84]) and from 6 months to more (aRR = 3.93 [95% CI: 2.39<jats:bold>–</jats:bold>6.45]) increased the risk of VF.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>HAART discontinuation increases the probability of TF and VF in Venezuelan immigrants.</jats:p></jats:sec>10Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis(2023)6Scopus© Citations 113 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Effectiveness of an inactivated SARS-CoV-2 vaccine in children and adolescents: a large-scale observational study(2023)7Scopus© Citations 15 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Successful treatment of cytomegalovirus retinitis with oral/intravitreal antivirals in HIV-negative patients with lymphoma(2022); Susan Lightman<jats:title>Abstract</jats:title><jats:sec> <jats:title>Objectives</jats:title> <jats:p>To report patients with systemic lymphoma and cytomegalovirus (CMV) retinitis, treated with a combination of oral and intravitreal antiviral agents on an outpatient basis.</jats:p> </jats:sec><jats:sec> <jats:title>Methods</jats:title> <jats:p>Retrospective cases series. Information was gathered from the database of the Uveitis clinics at Moorfields Eye Hospital, United Kingdom from December 2014 to December 2018. The inclusion criteria comprised the diagnosis of systemic lymphoma, associated with a diagnosis of CMV retinitis. Exclusion criteria were alternative ocular diagnosis, human immunodeficiency virus (HIV), primary intraocular lymphoma, or other causes of immunosuppression.</jats:p> </jats:sec><jats:sec> <jats:title>Results</jats:title> <jats:p>All seven subjects had been under oncologist care for systemic lymphoma. CMV retinitis presented with a median of 61 months after the systemic lymphoma diagnosis. Five patients underwent a vitreous biopsy, and four of them returned PCR positive for CMV and the fifth patient had PCR positive in a blood sample. All patients were treated with oral Valganciclovir, with an induction dose of 900 mg every 12 h for up to 3 weeks until disease resolution and a maintenance dose thereafter. All but one received additional intravitreal Foscarnet injections, with a dose of 2.4 mg /0.1 ml.</jats:p> </jats:sec><jats:sec> <jats:title>Conclusions</jats:title> <jats:p>The management of patients with systemic lymphoma and CMV retinitis with oral and intravitreal antiviral agents, resulted in effective disease control.</jats:p> </jats:sec>1Scopus© Citations 6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 18 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Evaluación de la infección por VIH en Chile: pronunciamiento del Comité VIH de la Academia Chilena de Medicina(2020); Raquel Child G.Scopus© Citations 9 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Infectious and non-infectious diseases burden among Haitian immigrants in Chile: a cross-sectional study(2020)20Scopus© Citations 11 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 18Scopus© Citations 7