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    The effect of computer prompt in breaks of sedentary behaviour among office workers: a systematic review and meta-analysis
    (Springer Science and Business Media LLC, 2025-06-13)
    LEPPE ZAMORA, JAIME ESTEBAN  
    ;
    Sara Ramos-Fuster
    ;
    Barbara Muñoz-Monari
    ;
    Sonia Roa-Alcaino
    ;
    Olga Lucía Sarmiento
    Background Prolonged sitting time in the workplace constitutes a significant portion of waking hours. Sedentary behaviour is associated with higher risks of cardiovascular diseases, obesity, and all-cause mortality. Interventions to reduce workplace sitting, such as health apps, height-adjustable desks, and active breaks, have shown relative effectiveness in improving health outcomes. Among these, computer prompt interventions represent a simple and scalable strategy that can remind workers to take breaks and reduce sedentary behaviour. This study evaluates the effectiveness of computer prompt interventions to reduce sitting at work compared to no intervention or combined strategies. Methods Primary studies were searched in PubMed (MEDLINE), EMBASE, Scopus, and CENTRAL of the Cochrane Library. The search was conducted until December 2024. Keywords included terms like “sedentary behaviour,” “computer prompts,” “sitting time,” and “office workers.” Only randomized controlled trials (individual or cluster) involving desk-based workers aged 18 or older that evaluated computer prompt software were included. Risk of bias was assessed using the Cochrane Risk-of-Bias tool (RoB2). Mean differences with 95% confidence intervals (CI) were calculated for sitting time and secondary outcomes. Analyses were performed using RevMan and R software, and GRADE methodology was applied to assess the certainty of evidence. Results From 17,880 records, 18 studies involving 1164 office workers were included in the analysis. Ten studies focused exclusively on computer prompts, while 8 studies implemented combined strategies (e.g., computer prompts plus sit-to-stand desks). The median intervention length was 8 weeks, ranging from one to 24 weeks. Studies using only computer prompts included breaks lasting from 1 to 10 min every 30 min up to an hour. Combined strategies included breaks from 6 to 30 min every 30 min up to 3 h. According to objective measurements, the meta-analysis showed a significant reduction of 12.46 min/workday in sitting time (95% CI: -18.12, -6.80) and a significant increase of 1029.99 steps/workday (95% CI: 815.97, 1244). Secondary outcomes included work-related, musculoskeletal, and cardiometabolic outcomes favouring computer prompts but not statistically significant. The certainty of evidence for primary outcomes is rated low to moderate according to GRADE. Conclusions Computer prompt software interventions show effectiveness in reducing sitting time among office workers. However, more long-term prospective studies with larger sample sizes are needed to accurately determine the effectiveness of computer prompts on various work- and health-related outcomes.
      3
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    The path of Chile towards the institutionalisation of evidence-based health policy
    (BMJ, 2025-03-20)
    Paula García-Celedón
    ;
    Deborah Navarro-Rosenblatt
    ;
    Carolina Ibarra-Castillo
    ;
    Lucy Kuhn-Barrientos
    ;
    Cristián Mansilla
      3
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    Retrospective study on disparities in time-to-treatment by health insurance system in Chilean breast cancer patients
    (Medwave Estudios Limitada, 2025-04-10)
    ACEVEDO ROMO, JOHANNA PATRICIA  
    ;
    Teresa Ip
    ;
    Lea Maureira
    ;
    Cesar Sanchez
    ;
    Claudia Osorio
    Introduction Breast cancer is the most common malignancy in the Americas, and the second leading cause of cancer death. Disparities in the time to treatment can significantly impact patient outcomes and typically affect lower socioeconomic individuals and/or ethnic minorities. Our study sought to evaluate disparities in time to treatment at three health institutions in Chile according to their type of health insurance (public or private). Methods Our study analyzed a database of breast cancer patients diagnosed between 2017 and 2018. Analyses included descriptive statistics and a linear regression model that incorporated clinical and demographic variables. Additionally, using a proportional risks model, we analyzed the association between clinical variables and mortality. Results Public health insurance (National Health Fund, FONASA) was associated with longer time-to-treatment and extended treatment times versus private health insurance (Social Security Institutions, ISAPRE; p < 0.0001). As expected, a more advanced stage at diagnosis was associated with lower survival. Our proportional risks model found that age was a predictor of breast cancer mortality in stage II patients. Also, total treatment time significantly increased the risk of breast cancer mortality in stage I patients. Conversely, total treatment time did not affect mortality on stages II or III. Conclusions We found significant disparities in the time to treatment of Chilean breast cancer patients using FONASA versus private ISAPRE. FONASA patients experience delays in the initiation of treatment and longer total treatment times compared to their private insurance counterparts. Finally, longer time-to-treatment was associated with more advanced stages and increased mortality.
      3
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    Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review
    (Springer Science and Business Media LLC, 2025-03-12)
    Álvaro Vergara A. Nieto
    ;
    Andrés Halabi Diaz
    ;
    Millaray Hernández
      2Scopus© Citations 4
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    Microvascular resistance reserve in relation to total and vessel-specific atherosclerotic burden
    (Oxford University Press (OUP), 2024-11-12)
    Masahiro Hoshino
    ;
    Ruurt A Jukema
    ;
    Roel Hoek
    ;
    Jorge Dahdal
    ;
    Pieter Raijmakers
    The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic burden and microvascular resistance reserve (MRR).</jats:p> Methods and results In this post hoc analysis of the PACIFIC 1 trial, symptomatic patients without prior coronary artery disease (CAD) underwent [15O]H2O positron emission tomography, coronary computed tomography angiography (CCTA), and invasive fractional flow reserve (FFR). MRR was assessed across all three coronary branches, utilizing PET-derived coronary flow reserve and invasive FFR measurements. CCTA was used to assess patient and vessel-specific plaque volumes. Percentage atheroma volume (PAV) was defined as total plaque volume divided by vessel volume. The study included 142 patients (55% male, 57.5 ± 8.6 years) with 426 vessels with a mean MRR of 3.77 ± 1.64. While a significantly higher PAV was observed in the left anterior descending artery territory, MRR was similar across the three coronary branches. Generalized estimating equations without correction for cardiovascular risk factors identified that patient-specific PAV tertiles but not vessel-specific PAV tertiles were related to vessel-specific MRR. After correction for cardiovascular risk factors, compared with the first tertile of patient-specific PAV, the second tertile showed a vessel-specific MRR decrease of β = −0.362, P = 0.018, and the third tertile showed a decrease of β = −0.347, P = 0.024.</jats:p> Conclusion In patients without prior CAD, patient-specific plaque burden was negatively associated to vessel-specific MRR; however, vessel-specific plaque burden was not related to vessel-specific MRR. Our findings suggest that the relation between atherosclerotic burden and an impaired microcirculatory function is of systemic origin.
      2
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    Knocking on Heaven’s Door? Entrepreneurship, Firm Growth, and Health Risks
    (2024)
    Jukka Partanen
    ;
    Aino Tenhiälä
    ;
    KAUTONEN, TEEMU UOLEVI  
    ;
    Markus Jokela
    ;
    Daniel A. Lerner
    We examine the physical health consequences to entrepreneurs of firm growth and decline. Using register-based panel data (2000–2021), we find that entrepreneurs and hired CEOs are, on average, healthier and live longer than individuals from a socio-economically similar random sample from the general population. However, our findings also reveal that entrepreneurs are more likely to fall ill during their tenure and die younger than hired CEOs. Importantly, our findings demonstrate that both cumulative exposure to growth and episodic, rapid declines in sales and in the number of employees are equally taxing for entrepreneurs and hired CEOs.
      1
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    Translating the behaviour change technique taxonomy version 1 into Spanish: Methodology and validation
    (2024)
    Oscar Castro
    ;
    Gabriela Fajardo  
    ;
    Marie Johnston
    ;
    LAROZE PREHN, DENISE ANGELIQUE  
    ;
    Eduardo Leiva-Pinto
    <ns5:p>Background Precise and unequivocal specification of intervention content is key to facilitating the accumulation and implementation of knowledge. The Behaviour Change Technique Taxonomy v1 (BCTTv1) is the most widely used classification of behaviour change techniques (BCTs), providing a shared, standardized vocabulary to identify the active ingredients of behavioural interventions. However, the BCTTv1 is only available in English and this hampers its broad use and adoption. The aim of the present article is to report the process of translation of the BCTTv1 into Spanish. Methods A bilingual team led the translation of the BCTTv1, involving seven iterative steps: (i) establish a Committee, (ii) forward translation from English to Spanish, (iii) back translation from Spanish to English, (iv) comparison of original BCTTv1 and back translation, (v) opportunistic comparison against an independent BCTTv1 translation, (vi) empirical testing, and (vii) final Committee review. Results Changes as a result of the translation process included relabelling BCTs, amending definitions, and fixing conceptual and grammatical inconsistencies, yielding the final version. Very satisfactory inter-coder reliability in BCT identification was observed as part of the empirical testing (i.e., prevalence and bias-adjusted kappa scores &gt; 0.8). Conclusions This work provides the Spanish-speaking population with a rigorous and validated BCTTv1 translation which can be used in both research and practice to provide a greater level of intervention detail for evidence synthesis, comparison, and replication of behaviour change interventions. The translation process described here may prove helpful to guide future translation efforts in behavioural science and beyond.</ns5:p>
    Scopus© Citations 7  2
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    Desafíos para el abordaje de la salud de los migrantes en Chile durante la pandemia por Covid-19: una revisión de alcance
    (2024)
    CABIESES VALDES, BALTICA BEATRIZ  
    ;
    Alice Blukacz
    ;
    Isabel Rada
    ;
    OBACH KING, ALEXANDRA ALICE  
    ;
    CARREÑO CALDERON, ALEJANDRA ANGELICA  
    <jats:p>Objetivo. Indagar sobre los principales desafíos reportados en el marco de la emergencia sanitaria de SARS-CoV-2 según la evidencia científica disponible a la fecha en esta materia en Chile. Material y métodos. Revisión de alcance con base en tres búsquedas en Web of Science, PubMed y Google Scholar de publicaciones en inglés y español publicadas entre 2020 y 2023. Resultados. Se identificaron tres áreas clave: desafíos de acceso y uso efectivo del sistema de salud, desafíos más allá del sistema de salud, incluyendo aquellas relaciones con determinantes sociales de la salud, autocuidado e información y, finalmente, desafíos de integración de los enfoques de interculturalidad, género y cooperación internacional. Conclusiones. Se evidencian oportunidades de mejorar el abordaje de la salud de personas migrantes internacionales en Chile a raíz de la pandemia por Covid-19, de cara a futuras crisis sanitarias y para reducir brechas e inequidades que impactan la salud poblacional.</jats:p>
    Scopus© Citations 1  1
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