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    New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides
    (2022)
    Truc T. Tran
    ;
    Sara Gomez Villegas
    ;
    Samuel L. Aitken
    ;
    Susan M. Butler-Wu
    ;
    Alex Soriano
    <jats:p>The long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections.</jats:p>
      5Scopus© Citations 29
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    Mechanisms of Antibiotic Resistance
    (2016)
    MUNITA SEPULVEDA, JOSE MANUEL  
    ;
    Cesar A. Arias
    ;
    Indira T. Kudva
    ;
    Qijing Zhang
    <jats:title>ABSTRACT</jats:title> <jats:p>Emergence of resistance among the most important bacterial pathogens is recognized as a major public health threat affecting humans worldwide. Multidrug-resistant organisms have not only emerged in the hospital environment but are now often identified in community settings, suggesting that reservoirs of antibiotic-resistant bacteria are present outside the hospital. The bacterial response to the antibiotic “attack” is the prime example of bacterial adaptation and the pinnacle of evolution. “Survival of the fittest” is a consequence of an immense genetic plasticity of bacterial pathogens that trigger specific responses that result in mutational adaptations, acquisition of genetic material, or alteration of gene expression producing resistance to virtually all antibiotics currently available in clinical practice. Therefore, understanding the biochemical and genetic basis of resistance is of paramount importance to design strategies to curtail the emergence and spread of resistance and to devise innovative therapeutic approaches against multidrug-resistant organisms. In this chapter, we will describe in detail the major mechanisms of antibiotic resistance encountered in clinical practice, providing specific examples in relevant bacterial pathogens.</jats:p>
      16Scopus© Citations 2051
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    Transferable Vancomycin Resistance in a Community-Associated MRSA Lineage
    (2014)
    Flávia Rossi
    ;
    Lorena Diaz
    ;
    Aye Wollam
    ;
    Diana Panesso
    ;
    Yanjiao Zhou
      11  1Scopus© Citations 153