New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides
Journal
Antimicrobial Agents and Chemotherapy
ISSN
0066-4804
1098-6596
Date Issued
2022
Author(s)
Truc T. Tran
Sara Gomez Villegas
Samuel L. Aitken
Susan M. Butler-Wu
Alex Soriano
Brian J. Werth
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>The long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections.</jats:p>
Cite this document
Tran, T. T., Gomez Villegas, S., Aitken, S. L., Butler-Wu, S. M., Soriano, A., Werth, B. J., & Munita, J. M. (2022). New perspectives on antimicrobial agents: Long-acting lipoglycopeptides. Antimicrobial Agents and Chemotherapy, 66(6), e02614-20. https://doi.org/10.1128/aac.02614-20
Subjects
resistant staphylococcus-aureus
;
in-vitro activity
;
gram-positive infections
;
cystic-fibrosis patient
;
real-world experience
;
acute bacterial skin
;
enterococcus-faecium
;
pharmacodynamic evaluation
;
intracellular activity
;
dalbavancin therapy
;
anti-bacterial agents
;
anti-infective agents
;
glycopeptides
;
gram-positive bacterial infections
;
humans
;
lipoglycopeptides
;
teicoplanin
;
dalbavancin
;
daptomycin
;
linezolid
;
lipoglycopeptide
;
oritavancin
;
rifampicin
;
teicoplanin
;
vancomycin
;
antiinfective agent
;
glycopeptide
;
teicoplanin
;
antibiotic sensitivity
;
antibiotic therapy
;
article
;
bacteremia
;
bacterial growth
;
bactericidal activity
;
bone and joint infections
;
broth dilution
;
clinical outcome
;
drug mechanism
;
enterococcus faecalis
;
enterococcus faecium
;
gene cluster
;
gram positive cocci
;
human
;
in vitro study
;
minimum inhibitory concentration
;
nonhuman
;
treatment duration
;
vancomycin resistance
;
vancomycin resistant enterococcus
;
chemistry
;
gram positive infection