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Adherence to an Early Exercise Plan Promotes Visceral Fat Loss in the First Month Following Bariatric Surgery
(Springer Science and Business Media LLC, 2025-02-14)
Johanna Pino-Zuñiga
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Paloma Lillo-Urzua
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Mariela Olivares-Galvez
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Ana Palacio-Aguero
;
Juan Camilo Duque
3Scopus© Citations 2
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Long-term quality of life in patients with bariatric surgery evaluated with BAROS
(2024)
Ana Palacio Agüero
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Ximena Díaz-Torrente
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Camila Zancheta
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Alejandra Reyes
;
Marcela Cosentino
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Rapid weight gain in wrestling athletes during the Panamerican Championship, Lima, 2018
(2020)
ESTEFANIA ALEJANDRA SOTO VOISIER
Scopus© Citations 2 1
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Approach to the Patient with Axial Spondyloarthritis and Suspected Inflammatory Bowel Disease
(2020)
IBAÑEZ, SEBASTIAN
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María Paz Poblete De La Fuente
;
Elisa Catalina Parra Cancino
3 1Scopus© Citations 2
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Neurolinfomatosis de los nervios ciático y mediano como presentación inicial del linfoma de linfocitos B
(2022)
BARAHONA ZULETA, DANIELA FRANCESCA
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I. Adlerstein
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J. Donoso
;
F. Mercado
Scopus© Citations 1 2
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The Autophagy Protein Pacer Positively Regulates the Therapeutic Potential of Mesenchymal Stem Cells in a Mouse Model of DSS-Induced Colitis
(2022)
Cristian A. Bergmann
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Sebastian Beltran
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Ana Maria Vega-Letter
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Paola Murgas
;
Maria Fernanda Hernandez
<jats:p>Mesenchymal stem cells (MSC) have emerged as a promising tool to treat inflammatory diseases, such as inflammatory bowel disease (IBD), due to their immunoregulatory properties. Frequently, IBD is modeled in mice by using dextran sulfate sodium (DSS)-induced colitis. Recently, the modulation of autophagy in MSC has been suggested as a novel strategy to improve MSC-based immunotherapy. Hence, we investigated a possible role of Pacer, a novel autophagy enhancer, in regulating the immunosuppressive function of MSC in the context of DSS-induced colitis. We found that Pacer is upregulated upon stimulation with the pro-inflammatory cytokine TNFα, the main cytokine released in the inflammatory environment of IBD. By modulating Pacer expression in MSC, we found that Pacer plays an important role in regulating the autophagy pathway in this cell type in response to TNFα stimulation, as well as in regulating the immunosuppressive ability of MSC toward T-cell proliferation. Furthermore, increased expression of Pacer in MSC enhanced their ability to ameliorate the symptoms of DSS-induced colitis in mice. Our results support previous findings that autophagy regulates the therapeutic potential of MSC and suggest that the augmentation of autophagic capacity in MSC by increasing Pacer levels may have therapeutic implications for IBD.</jats:p>
4Scopus© Citations 12
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Digital Therapeutics Care Utilizing Genetic and Gut Microbiome Signals for the Management of Functional Gastrointestinal Disorders: Results From a Preliminary Retrospective Study
(2022)
Shreyas V. Kumbhare
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Patricia A. Francis-Lyon
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Dashyanng Kachru
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Tejaswini Uday
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Carmel Irudayanathan
<jats:p>Diet and lifestyle-related illnesses including functional gastrointestinal disorders (FGIDs) and obesity are rapidly emerging health issues worldwide. Research has focused on addressing FGIDs via in-person cognitive-behavioral therapies, diet modulation and pharmaceutical intervention. Yet, there is paucity of research reporting on digital therapeutics care delivering weight loss and reduction of FGID symptom severity, and on modeling FGID status and symptom severity reduction including personalized genomic SNPs and gut microbiome signals. Our aim for this study was to assess how effective a digital therapeutics intervention personalized on genomic SNPs and gut microbiome signals was at reducing symptomatology of FGIDs on individuals that successfully lost body weight. We also aimed at modeling FGID status and FGID symptom severity reduction using demographics, genomic SNPs, and gut microbiome variables. This study sought to train a logistic regression model to differentiate the FGID status of subjects enrolled in a digital therapeutics care program using demographic, genetic, and baseline microbiome data. We also trained linear regression models to ascertain changes in FGID symptom severity of subjects at the time of achieving 5% or more of body weight loss compared to baseline. For this we utilized a cohort of 177 adults who reached 5% or more weight loss on the Digbi Health personalized digital care program, who were retrospectively surveyed about changes in symptom severity of their FGIDs and other comorbidities before and after the program. Gut microbiome taxa and demographics were the strongest predictors of FGID status. The digital therapeutics program implemented, reduced the summative severity of symptoms for 89.42% (93/104) of users who reported FGIDs. Reduction in summative FGID symptom severity and IBS symptom severity were best modeled by a mixture of genomic and microbiome predictors, whereas reduction in diarrhea and constipation symptom severity were best modeled by microbiome predictors only. This preliminary retrospective study generated diagnostic models for FGID status as well as therapeutic models for reduction of FGID symptom severity. Moreover, these therapeutic models generate testable hypotheses for associations of a number of biomarkers in the prognosis of FGIDs symptomatology.</jats:p>
30Scopus© Citations 12
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Ingesta calórica y de macronutrientes en los primeros seis meses post cirugía bariátrica
(2021)
Ana Cristina Palacio
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QUINTILIANO SCARPELLI DOURADO , DAIANA APARECIDA
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Paula Vargas
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Marcela Cosentino
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María José Ríos
7 1Scopus© Citations 3
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Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells
(2021)
Vikas Duhan
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Vishal Khairnar
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Simo Kitanovski
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Thamer A. Hamdan
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KLEIN POSTERNACK, ANDRES DAVID
<jats:p>Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (<jats:italic>Itgae</jats:italic>, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.</jats:p>
1Scopus© Citations 4
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Changes in body composition in patients following bariatric surgery: gastric bypass and sleeve gastrectomy
(2019)
Daiana Aparecida Quintiliano Scarpelli Dourado
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Ana Cristina Palacio Agüero
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Isidora Andrea Lira Carballal
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Paula Tamara Navarro Cañete
;
Valentina Orellana Guerrero
25 1Scopus© Citations 8

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