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    Intestinal protozoa in returning travellers: a GeoSentinel analysis from 2007 to 2019
    (2024)
    WEITZEL, THOMAS  
    ;
    Ashley Brown
    ;
    Michael Libman  
    ;
    Cecilia Perret
    ;
    Ralph Huits
    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background</jats:title> <jats:p>Prolonged diarrhoea is common amongst returning travellers and is often caused by intestinal protozoa. However, the epidemiology of travel-associated illness caused by protozoal pathogens is not well described.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>We analysed records of returning international travellers with illness caused by Giardia duodenalis, Cryptosporidium spp., Cyclospora cayetanensis or Cystoisospora belli, reported to the GeoSentinel Network during January 2007–December 2019. We excluded records of travellers migrating, with an unascertainable exposure country, or from GeoSentinel sites that were not located in high-income countries.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>There were 2517 cases, 82.3% giardiasis (n = 2072), 11.4% cryptosporidiosis (n = 287), 6.0% cyclosporiasis (n = 150) and 0.3% cystoisosporiasis (n = 8). Overall, most travellers were tourists (64.4%) on long trips (median durations: 18–30 days). Cryptosporidiosis more frequently affected people &amp;lt; 18 years (13.9%) and cyclosporiasis affected people ≥ 40 years (59.4%). Giardiasis was most frequently acquired in South Central Asia (45.8%) and sub-Saharan Africa (22.6%), cryptosporidiosis in sub-Saharan Africa (24.7%) and South-Central Asia (19.5%), cyclosporiasis in South East Asia (31.3%) and Central America (27.3%), and cystoisosporiasis in sub-Saharan Africa (62.5%). Cyclosporiasis cases were reported from countries of uncertain endemicity (e.g. Cambodia) or in countries with no previous evidence of this parasite (e.g. French Guiana). The time from symptom onset to presentation at a GeoSentinel site was the longest amongst travellers with giardiasis (median: 30 days). Over 14% of travellers with cryptosporidiosis were hospitalized.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This analysis provides new insights into the epidemiology and clinical significance of four intestinal protozoa that can cause morbidity in international travellers. These data might help optimize pretravel advice and post-travel management of patients with travel-associated prolonged gastrointestinal illnesses. This analysis reinforces the importance of international travel-related surveillance to identify sentinel cases and areas where protozoal infections might be undetected or underreported.</jats:p> </jats:sec>
      1Scopus© Citations 14
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    Differential Effects of a Telemonitoring Platform in the Development of Chemotherapy-Associated Toxicity: A Randomized Trial Protocol
    (2024)
    Felipe Martínez
    ;
    Carla Taramasco
    ;
    Manuel Espinoza
    ;
    ACEVEDO ROMO, JOHANNA PATRICIA  
    ;
    Carolina Goic
    <jats:p>Chemotherapy requires careful monitoring, but traditional follow-up approaches face significant challenges that were highlighted by the COVID-19 pandemic. Hence, exploration into telemonitoring as an alternative emerged. The objective is to assess the impact of a telemonitoring platform that provides clinical data to physicians overseeing solid tumor patients, aiming to enhance the care experience. The methodology outlines a parallel-group randomized clinical trial involving recently diagnosed patients with solid carcinomas preparing for curative intent chemotherapy. Eligible adult patients diagnosed with specific carcinoma types and proficient in Spanish, possessing smartphones, will be invited to participate. They will be randomized using concealed allocation sequences into two groups: one utilizing a specialized smartphone application called Contigo for monitoring chemotherapy toxicity symptoms and accessing educational content, while the other receives standard care. Primary outcome assessment involves patient experience during chemotherapy using a standardized questionnaire. Secondary outcomes include evaluating severe chemotherapy-associated toxicity, assessing quality of life, and determining user satisfaction with the application. The research will adhere to intention-to-treat principles. This study has been registered at ClinicalTrials.gov (NCT06077123).</jats:p>
      4Scopus© Citations 2
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      1
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    Epidemiology of Candidemia in Latin America: A Laboratory-Based Survey
    (2013)
    Marcio Nucci
    ;
    Flavio Queiroz-Telles
    ;
    Tito Alvarado-Matute
    ;
    Iris Nora Tiraboschi
    ;
    Jorge Cortes
    Scopus© Citations 312  2
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    Cluster of Imported Vivax Malaria in Travelers Returning From Peru
    (2015)
    Thomas Weitzel  
    ;
    Jaime Labarca
    ;
    Claudia P. Cortes
    ;
    Reinaldo Rosas
    ;
    M. Elvira Balcells
      4Scopus© Citations 3
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    The descriptive epidemiology of sitting in Chilean adults: Results from the National Health Survey 2009-2010
    (2019)
    Nicolas Aguilar-Farias
    ;
    Pia Martino-Fuentealba
    ;
    Andrea Cortinez-O'Ryan
    ;
    Damian Chandia-Poblete
    ;
    Carlos A. Celis-Morales
      5Scopus© Citations 6
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    International mass gatherings and travel-associated illness: A GeoSentinel cross-sectional, observational study
    (2019)
    Philippe Gautret
    ;
    Kristina M. Angelo
    ;
    Hilmir Asgeirsson
    ;
    Alexandre Duvignaud
    ;
    Perry J.J. van Genderen
      8Scopus© Citations 17
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