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Tackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action
(American Society for Microbiology, 2025-03-13)
DUARTE PEÑALOZA, LUISA FERNANDA
;
Javier Carbone-Schellman
;
Susan M. Bueno
;
Alexis M. Kalergis
;
Claudia A. Riedel
Antivirals play important roles in restricting viral diseases. Nevertheless, they act on a relatively limited number of viruses and occasionally display partial effectiveness in some tissues or against escape variants. Although vaccination remains the most cost-effective approach for preventing microbial diseases, developing prophylactic or therapeutic solutions for pathogens, such as herpes simplex viruses (HSVs), that effectively reduce their clinical manifestations in the skin has proven exceptionally challenging despite extensive research. Alternatively, a less explored approach for tackling HSV skin infection involves using topical immunomodulatory molecules to potentiate the host’s innate antiviral immune responses. When applied directly to herpetic skin lesions where viral antigen is present, this strategy has the potential to elicit virus-specific adaptive immunity. Based on currently available data, we foresee substantial potential for this approach in addressing HSV skin infections, along with additional prospects to advance understanding of skin biology and apply relevant new findings to other dermatological conditions. However, due to the limited number of case studies evaluating this method and its safety profile, particularly in immunocompromised individuals and pregnant women, further research is crucial, especially to assess the effects of immunomodulators in these vulnerable populations. Here, we revisit and discuss the use of immunomodulatory molecules for potentiating the host immune response against HSV skin infection and call for action for increased research and clinical trials regarding the possible benefits of this latter strategy for treating HSV cutaneous disease and recurrences. We also revisit and discuss antivirals and vaccine candidates against HSVs.
Scopus© Citations 2 7
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Women with polycystic ovary syndrome (PCOS): Likelihood of cooccurring neuropsychiatric conditions and the dual hit hypothesis
(Elsevier BV, 2025-04)
Juan Pablo Del Río
;
Alexandros Tsompanidis
;
Pablo A. Gaspar
;
Alejandro Maturana-Hurtado
;
Gonzalo M. Rojas-Costa
Scopus© Citations 7 6
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Myocardial perfusion imaging in advanced coronary artery disease
(Wiley, 2025-03-18)
Roel Hoek
;
Pepijn A. van Diemen
;
Yvemarie B. O. Somsen
;
Ruben W. de Winter
;
Ruurt A. Jukema
Myocardial perfusion imaging (MPI) is widely adapted as a noninvasive technique to assess the presence and extent of ischemia in patients with symptoms suggestive of obstructive coronary artery disease (CAD). However, as CAD advances, several factors can complicate the interpretation of MPI, subsequently impacting clinical decision‐making. This review focuses on the utility of MPI by means of cardiac magnetic resonance (CMR) imaging, single‐photon emission computed tomography (SPECT) and positron emission tomography (PET) in patients with advanced CAD—the latter characterized by documented CAD (i.e. prior myocardial infarction [MI] and/or percutaneous coronary intervention [PCI]), prior coronary artery bypass grafting (CABG) or the presence of a chronic total occlusion (CTO). It will discuss factors impacting the interpretation of MPI, the diagnostic performance for detecting obstructive CAD and coronary microvascular dysfunction (CMD), as well as the role of MPI in guiding revascularization.
Scopus© Citations 1 2
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Reducing global inequities in medical oxygen access: the Lancet Global Health Commission on medical oxygen security
(Elsevier BV, 2025-03)
Hamish R Graham
;
Carina King
;
Ahmed Ehsanur Rahman
;
Freddy Eric Kitutu
;
Leith Greenslade
Scopus© Citations 53 1
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Tumor hypoxia shapes natural killer cell anticancer activities
(Springer Science and Business Media LLC, 2025-05-30)
RETAMAL LUCERO, MAURICIO ANTONIO
;
Flavio Salazar-Onfray
;
Fermín E. González
;
Andrés Tittarelli
1
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The Presence of Associated Injuries in Pediatric Radial Neck Fractures: A Systematic Review of the Literature and Meta-Analysis of Pooled Individual Patient Data
(MDPI AG, 2025-02-27)
Lisette C. Langenberg
;
Joyce L. Benner
;
Nazira Bernal Bader
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Christiaan J. A. van Bergen
;
Joost W. Colaris
<jats:p>Background: Pediatric radial neck fractures (pRNFs) can occur in isolation or in association with concomitant injuries. It is unknown whether the presence of associated injuries should influence the choice of treatment. The aim of this study is to assess the incidence of associated injuries in pRNF and their correlation with fracture angulation (Judet grade) or the patient’s age (under or over ten years of age). Methods: A systematic literature review was performed following PRISMA-IPD guidelines, including case series on pRNF with a minimum of five cases of children until 16 years of age. The quality assessment included a risk of bias analysis and evaluation using the MINORS criteria. Individual patient data on age, Judet classification and associated injuries were extracted from the included studies and pooled for the meta-analysis. The correlation between the presence of associated injury and the patient’s age or Judet classification was depicted in two forest plots. Results: A total of 20 articles published sufficient individual patient data (n = 371) on associated injuries. All but one were retrospective case series. Fifteen articles had MINORS scores of 8 or higher. The incidence of associated injuries was 33% (123 of 371 cases). Almost half of the associated injuries included an olecranon fracture (61/123). There was no correlation between Judet classification (p = 0.243) and incidence nor between patient age and the incidence of associated injuries (p = 0.694). Conclusions: Surgeons should be aware of potential associated injuries in over a third of pRNF cases, regardless of the patient’s age or fracture angulation. Deduction of the trauma mechanism may be a more useful tool for assessing the potential presence of associated injuries than the most frequently used fracture classification or the patient’s age. More research is needed regarding the requirements for enhanced diagnostic imaging, specific treatment or follow-up adaptations in children with pRNFs and associated injuries.</jats:p>
4Scopus© Citations 1
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Psychiatric genetics in the diverse landscape of Latin American populations
(Springer Science and Business Media LLC, 2025-04-02)
Estela M. Bruxel
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Diego L. Rovaris
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Sintia I. Belangero
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Gabriela Chavarría-Soley
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Alfredo B. Cuellar-Barboza
4
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Are there Effective Vegan-Friendly Supplements for Optimizing Health and Sports Performance? a Narrative Review
(Springer Science and Business Media LLC, 2025-03-12)
Álvaro Vergara A. Nieto
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Andrés Halabi Diaz
;
Millaray Hernández
2Scopus© Citations 4
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Efficacy of platelet-rich-fibrin for the treatment of alveolar osteitis: a systematic review and meta-analysis
(Medicina Oral, S.L., 2025)
C. Ávila-Oliver
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V. Veloso
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G. Laissle
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AM. Rojas
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F. Verdugo-Paiva
2
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Latin American association for the study of the liver (ALEH) guidance on postoperative care after liver transplantation
(Elsevier BV, 2025-07)
Liana Codes
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ZAPATA LARRAIN, RODRIGO
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Manuel Mendizabal
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Alfeu de Medeiros Fleck Junior
;
Juan Carlos Restrepo
7Scopus© Citations 1

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