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      10Scopus© Citations 12
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    NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease
    (2012)
    Daniel Martinez-Fong
    ;
    Michael J. Bannon
    ;
    Louis-Eric Trudeau
    ;
    Juan A. Gonzalez-Barrios
    ;
    Martha L. Arango-Rodriguez
      3Scopus© Citations 56
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    Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review
    (2023)
    Florencia Antunovic
    ;
    Felipe Tolosa
    ;
    Catherine Klein
    ;
    René Ocaranza
    <jats:sec><jats:title>Background:</jats:title><jats:p> Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential. </jats:p></jats:sec>
    Scopus© Citations 15
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    History, control, epidemiology, ecology, and economy of the invasion of European rabbits in Chile: a comparison with Australia
    (2022)
    Jennifer Paola Correa-Cuadros
    ;
    Gabriela Flores-Benner
    ;
    Manuel Andrés Muñoz-Rodríguez
    ;
    Cristóbal Briceño
    ;
    Miguel Díaz
    Scopus© Citations 10  1
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      26Scopus© Citations 30
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    Changes in the regulation of the Notch signaling pathway are temporally correlated with regenerative failure in the mouse cochlea
    (2015)
    Juan C. Maass
    ;
    Rende Gu
    ;
    Martin L. Basch
    ;
    Joerg Waldhaus
    ;
    Eduardo Martin Lopez
    Scopus© Citations 78  12
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    The Reparative Abilities of Menstrual Stem Cells Modulate the Wound Matrix Signals and Improve Cutaneous Regeneration
    (2018)
    Jimena Cuenca
    ;
    Alice Le-Gatt
    ;
    Valentina Castillo
    ;
    Jose Belletti
    ;
    Macarena Díaz
      18Scopus© Citations 47
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    Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity
    (2019)
    Christina M. A. P. Schuh
    ;
    Sebastian Aguayo
    ;
    Gabriela Zavala
    ;
    Maroun Khoury
    <jats:p>Microvesicles have become key players in cellular communication. Since glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland secretomal products (honey, royal jelly and bee pollen), and participate in their known antibacterial and pro-regenerative effects. We developed an isolation protocol based on serial- and ultracentrifugation steps and demonstrated the presence of protein-containing exosome-like vesicles in all three bee-derived products. Assessing their antibacterial properties, we found that exosome-like vesicles had bacteriostatic, bactericidal and biofilm-inhibiting effects on Staphylococcus aureus. Furthermore, we could demonstrate that mesenchymal stem cells (MSCs) internalize bee-derived exosome-like vesicles and that these vesicles influence their migration potential. In an in vitro wound healing assay, honey and royal jelly exosome-like vesicles increased migration of human MSC, demonstrating their interkingdom activity. Summarizing, we have discovered exosome-like vesicles as a new, active compound in bee pollen, honey and royal jelly.</jats:p>
    Scopus© Citations 49  1