Polycaprolactone-based scaffolds for guided tissue regeneration in periodontal therapy: A systematic review
Journal
Journal of Applied Biomaterials & Functional Materials
ISSN
2280-8000
2280-8000
Date Issued
2023
Author(s)
Florencia Antunovic
Catherine Klein
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:sec><jats:title>Background:</jats:title><jats:p> Polycaprolactone (PCL) is a highly recognized synthetic polymer for its biocompatibility, ease of fabrication and mechanical strength in bone tissue engineering. Its applications have extended broadly, including regeneration of oral and maxillofacial lost tissues. Its usefulness has brought attention of researchers to regenerate periodontal lost tissues, including alveolar bone, periodontal ligament and cementum. The aim of this systematic review was to obtain an updated analysis of the contribution of PCL-based scaffolds in the alveolar bone regeneration process. </jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p> This review adheres to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines for systematic reviews. A computerized search of the PubMed, EBSCO, Scielo and Web of Science databases was performed, restricting literature search to published studies in English or Spanish between January 2002 and March 2023. Database search returned 248 studies which were screened based on title, author names and publication dates. </jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p> Data from 17 studies were reviewed and tabulated. All studies combined PCL with other biomaterials (such as Alginate, hydroxyapatite, bioactive glass, poly (lactic-co-glycolic acid)), growth factors (BMP-2, rhCEMP1), and/or mesenchymal stromal cells (adipose-derived, bone marrow, periodontal ligament or gingiva mesenchymal stromal cells). PCL scaffolds showed higher cell viability and osteoinductive potential when combined with bioactive agents. Complementary, its degradation rates were affected by the addition or exposure to specific substances, such as: Dopamine, Cerium Oxide, PLGA and hydrogen peroxide. </jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p> PCL is an effective biomaterial for alveolar bone regeneration in periodontally affected teeth. It could be part of a new generation of biomaterials with improved regenerative potential. </jats:p></jats:sec>
Subjects
guided bone regeneration
;
periodontal regeneration
;
polycaprolactone scaffold
;
biocompatible materials
;
bone regeneration
;
guided tissue regeneration
;
tissue engineering
;
tissue scaffolds
;
amines
;
biocompatibility
;
bone
;
cerium oxide
;
degradation
;
histology
;
hydroxyapatite
;
scaffolds (biology)
;
alginic acid
;
alkaline phosphatase
;
biomaterial
;
bone morphogenetic protein 2
;
calcium phosphate
;
cerium oxide
;
collagen type 1
;
dopamine
;
hydrogen peroxide
;
hydroxyapatite
;
molecular scaffold
;
osteocalcin
;
osteopontin
;
polycaprolactone
;
polyglactin
;
simvastatin
;
transcription factor runx2
;
polycaprolactone
;
alveolar bones
;
bone regeneration
;
guided bone regeneration
;
guided tissue regeneration
;
mesenchymal stromal cells
;
periodontal ligament
;
periodontal regeneration
;
polycaprolactone scaffolds
;
synthetic polymers
;
systematic review
;
adipose derived stem cell
;
alveolar bone
;
biocompatibility
;
biomechanics
;
bone development
;
bone marrow
;
bone marrow mesenchymal stem cell
;
bone regeneration
;
bone tissue
;
cell differentiation
;
cell proliferation
;
cell viability
;
dental procedure
;
gene expression
;
gingiva
;
human
;
mesenchymal stem cell
;
mesenchymal stroma cell
;
mtt assay
;
newcastle-ottawa scale
;
osteoblast
;
osteosarcoma
;
outcome assessment
;
periodontal disease
;
periodontal ligament
;
periodontal therapy
;
periodontitis
;
randomized controlled trial (topic)
;
regeneration
;
regenerative medicine
;
review
;
review
;
risk assessment
;
stroma cell
;
systematic review
;
tissue engineering
;
tissue regeneration
;
tissue regeneration