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    Scopus© Citations 12  1
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    Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis
    (2023)
    Emily R Smith
    ;
    Erin Oakley
    ;
    Gargi Wable Grandner
    ;
    Kacey Ferguson
    ;
    Fouzia Farooq
    <jats:sec><jats:title>Introduction</jats:title><jats:p>Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women.</jats:p><jats:p>Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12).</jats:p><jats:p>Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>This analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.</jats:p></jats:sec>
      7Scopus© Citations 143
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      6Scopus© Citations 114
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    Reactivation of adult-onset Still’s disease after use of the COVID-19 ChAdOx1-S vaccine
    (2022)
    Sebastián E Ibáñez Vodnizza
    ;
    Luis Morales Murillo
    ;
    Matías de la Rivera Vergara
    ;
    Roberto Saldías Martínez
    <jats:p>A woman in her 60s with a history of adult-onset Still’s disease (AOSD) in remission for 14 years received the ChAdOx1-S vaccine as a booster to her initial vaccination schedule (two doses of CoronaVac vaccine 6 months apart). Two weeks later, she consulted for symptoms suggestive of AOSD reactivation. This was confirmed during hospitalisation, where renal and cardiac involvement were also observed. Despite using high-dose corticosteroids, troponin T and N-terminal pro hormone B-type natriuretic peptide (NT-proBNP) were persistently elevated. Tocilizumab was used, with which the patient achieved complete remission of her symptoms and normalised her laboratory tests.</jats:p>
      22Scopus© Citations 4
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    Oxygen desaturation and adverse outcomes in acute stroke: Secondary analysis of the HeadPoST study
    (2021)
    Menglu Ouyang
    ;
    Christine Roffe
    ;
    Laurent Billot
    ;
    Lili Song
    ;
    Xia Wang
      1Scopus© Citations 2  1
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      12Scopus© Citations 9
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    Dexmedetomidine Improves Cardiovascular and Ventilatory Outcomes in Critically Ill Patients: Basic and Clinical Approaches
    (2020)
    Rodrigo L. Castillo
    ;
    Mauricio Ibacache
    ;
    Ignacio Cortínez
    ;
    Catalina Carrasco-Pozo
    ;
    Jorge G. Farías
    Scopus© Citations 51  2
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    Chorionic Bump: An Early Ultrasound Marker for Adverse Obstetric Outcome
    (2019)
    María Carolina Silva
    ;
    Alvaro Sepúlveda-Martínez
    ;
    Rodolfo Guíñez
    ;
    María Teresa Haye
    ;
    Mauro Parra-Cordero
    <jats:p>&lt;b&gt;&lt;i&gt;Backgrounds/Aims:&lt;/i&gt;&lt;/b&gt; To assess the perinatal outcome of pregnancies with chorionic bump detected at the first trimester of pregnancy. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; This was a nested case-control study of pregnancies with chorionic bump identified at the first trimester ultrasound that was performed from October 2014 and October 2016. The control group consisted of the following 5 unaffected pregnancies after each case. From the first trimester ultrasound, maternal and perinatal characteristics were obtained and stored in a dedicated database. The primary outcome was defined as the presence of an alive new-born. Secondary outcome was defined as the presence of a composite adverse obstetric outcome. &lt;b&gt;&lt;i&gt;Results&lt;/i&gt;&lt;/b&gt;: Eleven first trimester pregnancies affected by a chorionic bump and 55 controls were identified. The primary outcome was observed in 72.7 and 89.1% of chorionic bump and controls respectively (&lt;i&gt;p&lt;/i&gt; = 0.2). The secondary outcome was observed in 45.5% of pregnancies with a chorionic bump versus 12.7% in the unaffected group (&lt;i&gt;p&lt;/i&gt; = 0.01). First trimester uterine artery Doppler demonstrated a non-significant trend to be higher in the chorionic bump group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; The presence of a chorionic bump is associated with a significant higher risk of adverse perinatal outcome.</jats:p>
    Scopus© Citations 11  2
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    Immune Checkpoint Inhibitor-Associated Pericarditis
    (2019)
    Mehmet Altan
    ;
    Maria I. Toki
    ;
    Scott N. Gettinger
    ;
    CARVAJAL HAUSDORF, DANIEL EDUARDO  
    ;
    Jon Zugazagoitia
    Scopus© Citations 77  1
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    Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the HeadPoST study.
    (2019)
    Jatinder S. Minhas
    ;
    Xia Wang
    ;
    Pablo M. Lavados
    ;
    Tom J. Moullaali
    ;
    Hisatomi Arima
      6Scopus© Citations 34