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Multisite Detection of Tn
<i>1549</i>
-Mediated
<i>vanB</i>
Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida
(2023)
Shelby R. Simar
;
Truc T. Tran
;
Kirsten B. Rydell
;
Diana Panesso
;
German A. Contreras
<jats:p> In the United States, <jats:italic>vanB</jats:italic> -mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant <jats:named-content content-type="genus-species">Enterococcus faecalis</jats:named-content> isolates causing bacteremia in unique patients in spatiotemporally distinct settings. </jats:p>
7 1Scopus© Citations 3
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A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis
(2014)
Jinnethe Reyes
;
Diana Panesso
;
Truc T. Tran
;
Nagendra N. Mishra
;
Melissa R. Cruz
7 1Scopus© Citations 82
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New Perspectives on Antimicrobial Agents: Long-Acting Lipoglycopeptides
(2022)
Truc T. Tran
;
Sara Gomez Villegas
;
Samuel L. Aitken
;
Susan M. Butler-Wu
;
Alex Soriano
<jats:p>The long-acting lipoglycopeptides (LGPs) dalbavancin and oritavancin are semisynthetic antimicrobials with broad and potent activity against Gram-positive bacterial pathogens. While they are approved by the Food and Drug Administration for acute bacterial skin and soft tissue infections, their pharmacological properties suggest a potential role of these agents for the treatment of deep-seated and severe infections, such as bloodstream and bone and joint infections.</jats:p>
5Scopus© Citations 29
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Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
(2014)
MUNITA SEPULVEDA, JOSE MANUEL
;
Nagendra N. Mishra
;
Danya Alvarez
;
Truc T. Tran
;
Lorena Diaz
13 1Scopus© Citations 57
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Influence of Minimum Inhibitory Concentration in Clinical Outcomes of Enterococcus faecium Bacteremia Treated With Daptomycin: Is it Time to Change the Breakpoint?
(2016)
Bhavarth S. Shukla
;
Samuel Shelburne
;
Katherine Reyes
;
Mini Kamboj
;
Jessica D. Lewis
6 1Scopus© Citations 92
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Influence of Inoculum Effect on the Efficacy of Daptomycin Monotherapy and in Combination with beta-Lactams against Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions
(2018)
Razieh Kebriaei
;
Seth A. Rice
;
Kavindra V. Singh
;
Kyle C. Stamper
;
An Q. Dinh
<jats:p> <jats:named-content content-type="genus-species">Enterococcus faecium</jats:named-content> isolates that harbor LiaFSR substitutions but are phenotypically susceptible to daptomycin (DAP) by current breakpoints are problematic, since predisposition to resistance may lead to therapeutic failure. Using a simulated endocardial vegetation (SEV) pharmacokinetic/pharmacodynamic (PK/PD) model, we investigated DAP regimens (6, 8, and 10 mg/kg of body weight/day) as monotherapy and in combination with ampicillin (AMP), ceftaroline (CPT), or ertapenem (ERT) against <jats:named-content content-type="genus-species">E. faecium</jats:named-content> HOU503, a DAP-susceptible strain that harbors common LiaS and LiaR substitutions found in clinical isolates (T120S and W73C, respectively). </jats:p>
3 1Scopus© Citations 37

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