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Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses
(2023)
Simón Álvarez
;
Pamina Contreras-Kallens
;
Sebastian Aguayo
;
Ramírez Prada, Orlando
;
Catalina Vallejos
1Scopus© Citations 17 4
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Type I collagen hydrogels as a delivery matrix for royal jelly derived extracellular vesicles
(2020)
Orlando J. Ramírez
;
Simón Alvarez
;
Pamina Contreras-Kallens
;
Nelson P. Barrera
;
Sebastian Aguayo
7Scopus© Citations 34
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Antibacterial Effect of Honey-Derived Exosomes Containing Antimicrobial Peptides Against Oral Streptococci
(2021)
Camila Leiva-Sabadini
;
Simon Alvarez
;
Nelson P Barrera
;
Christina MAP Schuh
;
Sebastian Aguayo
Scopus© Citations 39 3
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Potential Novel Strategies for the Treatment of Dental Pulp-Derived Pain: Pharmacological Approaches and Beyond
(2019)
SCHUH, CHRISTINA
;
Bruna Benso
;
Sebastian Aguayo
12 1Scopus© Citations 21
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Exosome-like vesicles in Apis mellifera bee pollen, honey and royal jelly contribute to their antibacterial and pro-regenerative activity
(2019)
Christina M. A. P. Schuh
;
Sebastian Aguayo
;
Gabriela Zavala
;
Maroun Khoury
<jats:p>Microvesicles have become key players in cellular communication. Since glandular secretions present a rich source of active exosomes, we hypothesized that exosome-like vesicles are present in Apis mellifera hypopharyngeal gland secretomal products (honey, royal jelly and bee pollen), and participate in their known antibacterial and pro-regenerative effects. We developed an isolation protocol based on serial- and ultracentrifugation steps and demonstrated the presence of protein-containing exosome-like vesicles in all three bee-derived products. Assessing their antibacterial properties, we found that exosome-like vesicles had bacteriostatic, bactericidal and biofilm-inhibiting effects on Staphylococcus aureus. Furthermore, we could demonstrate that mesenchymal stem cells (MSCs) internalize bee-derived exosome-like vesicles and that these vesicles influence their migration potential. In an in vitro wound healing assay, honey and royal jelly exosome-like vesicles increased migration of human MSC, demonstrating their interkingdom activity. Summarizing, we have discovered exosome-like vesicles as a new, active compound in bee pollen, honey and royal jelly.</jats:p>
Scopus© Citations 49 1

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