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Author: search.filters.author.Claudia A. Riedel

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    Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring
    (Springer Science and Business Media LLC, 2025-11-26)
    Enrique González-Madrid
    ;
    Ma. Andreina Rangel-Ramírez
    ;
    María C. Opazo
    ;
    Sebastián A. Espinoza
    ;
    Daniela Elgueta
    Scopus© Citations 1  4
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    HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
    (Elsevier BV, 2025-05)
    Mónica A. Farías
    ;
    Felipe A. Cancino
    ;
    Areli J. Navarro
    ;
    DUARTE PEÑALOZA, LUISA FERNANDA  
    ;
    Abel A. Soto
    Scopus© Citations 6  8
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    Tackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action
    (American Society for Microbiology, 2025-03-13)
    DUARTE PEÑALOZA, LUISA FERNANDA  
    ;
    Javier Carbone-Schellman
    ;
    Susan M. Bueno
    ;
    Alexis M. Kalergis
    ;
    Claudia A. Riedel
    Antivirals play important roles in restricting viral diseases. Nevertheless, they act on a relatively limited number of viruses and occasionally display partial effectiveness in some tissues or against escape variants. Although vaccination remains the most cost-effective approach for preventing microbial diseases, developing prophylactic or therapeutic solutions for pathogens, such as herpes simplex viruses (HSVs), that effectively reduce their clinical manifestations in the skin has proven exceptionally challenging despite extensive research. Alternatively, a less explored approach for tackling HSV skin infection involves using topical immunomodulatory molecules to potentiate the host’s innate antiviral immune responses. When applied directly to herpetic skin lesions where viral antigen is present, this strategy has the potential to elicit virus-specific adaptive immunity. Based on currently available data, we foresee substantial potential for this approach in addressing HSV skin infections, along with additional prospects to advance understanding of skin biology and apply relevant new findings to other dermatological conditions. However, due to the limited number of case studies evaluating this method and its safety profile, particularly in immunocompromised individuals and pregnant women, further research is crucial, especially to assess the effects of immunomodulators in these vulnerable populations. Here, we revisit and discuss the use of immunomodulatory molecules for potentiating the host immune response against HSV skin infection and call for action for increased research and clinical trials regarding the possible benefits of this latter strategy for treating HSV cutaneous disease and recurrences. We also revisit and discuss antivirals and vaccine candidates against HSVs.
    Scopus© Citations 2  7
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    Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
    (2024)
    DUARTE PEÑALOZA, LUISA FERNANDA  
    ;
    Verónica Villalobos
    ;
    Mónica A. Farías
    ;
    Ma. Andreina Rangel-Ramírez
    ;
    Enrique González-Madrid
    Experimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of healthy individuals are likely to have asymptomatic HSV-1 brain infection with chronic brain inflammation due to persistent latent infection in neurons. Because cellular senescence is suggested as a potential factor contributing to the development of various neurodegenerative disorders, including multiple sclerosis, and viral infections may induce a premature senescence state in the CNS, potentially increasing susceptibility to such disorders, here we examine the presence of senescence-related markers in the brains and spinal cords of mice with asymptomatic HSV-1 brain infection, EAE, and both conditions. Across all scenarios, we find a significant increases of senescence biomarkers in the CNS with some differences depending on the analyzed group. Notably, some senescence biomarkers are exclusively observed in mice with the combined conditions. These results indicate that asymptomatic HSV-1 brain infection and EAE associate with a significant expression of senescence biomarkers in the CNS.
    Scopus© Citations 2  5