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Item type:Publication, Resistance to novel β-lactam/β-lactamase inhibitors among carbapenem-resistant
<i>Pseudomonas aeruginosa</i>
and clinical implications in the prospective observational
<i>Pseudomonas</i>
study(American Society for Microbiology, 2026-06-03)6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Carbapenem-resistant Enterobacterales in solid organ transplant recipients(2024)1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in
<i>Pseudomonas aeruginosa</i>
of clinical origin(2024); JOSE RODRIGO WALDEMAR MARTINEZ SOLIS<jats:title>ABSTRACT</jats:title> <jats:sec> <jats:title/> <jats:p> The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) <jats:italic>P. aeruginosa</jats:italic> (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of <jats:italic>P. aeruginosa</jats:italic> and the phenotypic effect on FDC susceptibility and heteroresistance. We evaluated the sequence of <jats:italic>pirR</jats:italic> , <jats:italic>pirS</jats:italic> , <jats:italic>pirA</jats:italic> , <jats:italic>piuA</jats:italic> , or <jats:italic>piuD</jats:italic> from 498 unique isolates collected before the introduction of FDC from four clinical sites in Portland, OR (1), Houston, TX (2), and Santiago, Chile (1). At some clinical sites, TBDR mutations were seen in up to 25% of isolates, and insertion, deletion, or frameshift mutations were predicted to impair protein function were seen in 3% of all isolates ( <jats:italic>n</jats:italic> = 15). Using population analysis profile testing, we found that <jats:italic>P. aeruginosa</jats:italic> with major TBDR mutations were enriched for a heteroresistant phenotype and undergo a shift in the susceptibility distribution of the population as compared to susceptible strains with wild-type TBDR genes. Our results indicate that mutations in TBDR genes predate the clinical introduction of FDC, and these mutations may predispose to the emergence of FDC resistance. </jats:p> </jats:sec>Scopus© Citations 18 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Surveillance infrastructure is essential to address antimicrobial resistance in the Americas(2024); Scopus© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Surveillance infrastructure is essential to address antimicrobial resistance in the Americas(2024)Scopus© Citations 1 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Lives lost and disease burden related to antimicrobial resistance in the Americas can no longer be ignored(2023)2Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Multisite Detection of Tn
<i>1549</i>
-Mediated
<i>vanB</i>
Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida(2023)7 1Scopus© Citations 3 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Antimicrobial Susceptibility Testing for Enterococci(2022); Cesar A. Arias<jats:p>Enterococci are major, recalcitrant nosocomial pathogens with a wide repertoire of intrinsic and acquired resistance determinants and the potential of developing resistance to all clinically available antimicrobials. As such, multidrug-resistant enterococci are considered a serious public health threat.</jats:p>1Scopus© Citations 57 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Real-World Performance of Susceptibility Testing for Ceftolozane/Tazobactam against Non-Carbapenemase-Producing Carbapenem-Resistant Pseudomonas aeruginosa(2022); 19Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Genomic Epidemiology of Vancomycin-Resistant Enterococcus faecium (VREfm) in Latin America: Revisiting The Global VRE Population Structure(2020)1Scopus© Citations 47 1