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A Natural deep eutectic solvent as an effective material for dual debridement and antibiofilm effects in chronic wound treatment
(2024)
SCHUH, CHRISTINA
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EZQUER, EDUARDO FERNANDO
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MAMANI FLORES, SIGDE KARINA
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CAMPODONICO GALDAMES, PAOLA ROSSANA
;
Constanza Cárcamo
Scopus© Citations 1 6
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The Immunoregulatory and Regenerative Potential of Activated Human Stem Cell Secretome Mitigates Acute-on-Chronic Liver Failure in a Rat Model
(2024)
Barbara Cuadra
;
Veronica Silva
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HUANG, YA LIN
;
Yael Diaz
;
Claudio Rivas
<jats:p>Acute-on-chronic liver failure (ACLF) is a syndrome marked by sudden liver function decline and multiorgan failure, predominantly acute kidney injury (AKY), in patients with chronic liver disease. Unregulated inflammation is a hallmark of ACLF; however, the key drivers of ACLF are not fully understood. This study explores the therapeutic properties of human mesenchymal stem cell (MSC) secretome, particularly focusing on its enhanced anti-inflammatory and pro-regenerative properties after the in vitro preconditioning of the cells. We evaluated the efficacy of the systemic administration of MSC secretome in preventing liver failure and AKI in a rat ACLF model where chronic liver disease was induced using by the administration of porcine serum, followed by D-galN/LPS administration to induce acute failure. After ACLF induction, animals were treated with saline (ACLF group) or MSC-derived secretome (ACLF-secretome group). The study revealed that MSC-secretome administration strongly reduced liver histological damage in the ACLF group, which was correlated with higher hepatocyte proliferation, increased hepatic and systemic anti-inflammatory molecule levels, and reduced neutrophil and macrophage infiltration. Additionally, renal examination revealed that MSC-secretome treatment mitigated tubular injuries, reduced apoptosis, and downregulated injury markers. These improvements were linked to increased survival rates in the ACLF-secretome group, endorsing MSC secretomes as a promising therapy for multiorgan failure in ACLF.</jats:p>
Scopus© Citations 6 3
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Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses
(2023)
Simón Álvarez
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Pamina Contreras-Kallens
;
Sebastian Aguayo
;
Ramírez Prada, Orlando
;
Catalina Vallejos
1 4Scopus© Citations 30

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