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Item type:Publication, Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series(2021) ;Yvette N Löwensteyn ;Harish Nair ;Marta C Nunes ;Ichelle van RoesselFemke S Vernooij12Scopus© Citations 5 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Estimated impact of maternal vaccination on global paediatric influenza-related in-hospital mortality: A retrospective case series(2021) ;Yvette N Löwensteyn ;Harish Nair ;Marta C Nunes ;Ichelle van RoesselFemke S VernooijScopus© Citations 4 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, 3Scopus© Citations 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Scopus© Citations 1 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Severe pertussis: State of the art(2012) ;Alejandro Donoso ;Daniela Arriagada Santis ;Pablo CrucesFranco Díaz1Scopus© Citations 17 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Sífilis congénita: presentación como shock séptico después del período neonatal(2012) ;Daniela Arriagada ;Alejandro Donoso ;Pablo CrucesFranco Díaz6Scopus© Citations 6 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Respiratory and hemodynamic effects of a stepwise lung recruitment maneuver in pediatric ARDS: A feasibility study(2012) ;Pablo Cruces ;Alejandro Donoso ;Jorge ValenzuelaFranco DíazBackgroundLittle is known about the efficacy and safety of recruitment maneuvers (RMs) in pediatric patients with acute respiratory distress syndrome (ARDS). We therefore assessed the effects on gas exchange and lung mechanics and the possible detrimental effects of a sequential lung RMs and decremental positive end-expiratory pressure (PEEP) titration in pediatric ARDS patients. MethodsWe enrolled patients <15 years of age with ARDS, progressive hypoxemia, <72hr of mechanical ventilation, and hemodynamic stability. A step-wise RM and decremental PEEP trial were performed. Safety was evaluated as the occurrence of hypotension and low pulse oxymeter oxygen saturation during the maneuver and development of airleaks after. Efficacy was evaluated as changes in lung compliance (C-dyn) and gas exchange 1, 12, and 24hr after the RM. ResultsWe included 25 patients, of median age 5 (1-16) months, median weight 7.0 (4.1-9.2)kg, median PaO2/FIO2 117 (96-139), and median C-dyn 0.48 (0.41-0.68)ml/cmH(2)O/kg at baseline. Thirty RM were performed, with all completed successfully. No airleaks developed. Mild hypotension was detected during four procedures. Following RM, C-dyn, and PaO2/FIO2 increased significantly (P<0.01 each), without changes in PaCO2 (P=0.4). A >25% improvement in lung function (C-dyn or PaO2/FIO2) was observed after 90% of the RM procedures. Gas exchange worsening over the next 24hr resulted in HFOV use in 36% of patients, while the remaining subjects sustained improvements in oxygenation at 12 and 24hr. The 28-day mortality rate was 16%. ConclusionsSequential RMs were safe and well tolerated in hemodynamically stable children with ARDS. RMs and a decremental PEEP trial may improve lung function in pediatric patients with ARDS and severe hypoxemia. Pediatr Pulmonol. 2013; 48:1135-1143. (c) 2012 Wiley Periodicals, Inc.3Scopus© Citations 31 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Surfactant deactivation in a pediatric model induces hypovolemia and fluid shift to the extravascular lung compartment(2012) ;FRANCO JAVIER DIAZ RUBIO ;Benjamín Erranz ;Alejandro Donoso; Tatiana SalomónSurfactant deficiency is the pivotal abnormality in Neonatal and Acute Respiratory Distress Syndrome. Surfactant deactivation can produce hypoxemia, loss of lung compliance, and pulmonary edema, but its circulatory consequences are less understood. Objective To describe the sequential hemodynamic changes and pulmonary edema formation after surfactant deactivation in piglets. Methods: Surfactant deactivation was induced by tracheal instillation of polysorbate 20 in 15 anesthetized and mechanically ventilated Large White piglets. The hemodynamic consequences of surfactant deactivation were assessed at 30, 120, and 240 min by transpulmonary thermodilution and traditional methods. Results: Surfactant deactivation caused hypoxemia, reduced lung compliance, and progressively increased lung water content (P < 0.01). Early hypovolemia was observed, with reductions of the global end-diastolic volume and stroke volume (P < 0.05). Reduced cardiac output was observed at the end of the study (P < 0.05). Standard monitoring was unable to detect these early preload alterations. Surprisingly, the bronchoalveolar protein content was greatly increased at the end of the study compared with baseline levels (P < 0.01). This finding was inconsistent with the notion that the pulmonary edema induced by surfactant deactivation was exclusively caused by high surface tension. Conclusions: Hypovolemia develops early after surfactant deactivation, in part due to the resulting fluid shift from the intravascular compartment to the lungsScopus© Citations 5 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Utilidad de la termodilución transpulmonar en el manejo del paciente pediátrico hipoxémico con neumonía por varicela(2012) ;Daniela Arriagada ;Alejandro Donoso ;CRUCES PABLOF. DíazScopus© Citations 2 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mild hypothermia attenuates lung edema and plasma interleukin-1β in a rat mechanical ventilation-induced lung injury model(2011) ;Cruces, Pablo ;Ronco, Ricardo ;Benjamín Erranz; 33Scopus© Citations 9