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Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit
(2017)
LARRAIN VALENZUELA, MARIA JOSEFINA
;
ZAMORANO M, FRANCISCO JAVIER
;
Patricia Soto Icaza
;
Ximena Carrasco
;
Claudia Herrera
A dysfunction in the excitatory–inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder.
Scopus© Citations 51 7
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Clinicians’ preferences and attitudes towards the use of lithium in the maintenance treatment of bipolar disorders around the world: a survey from the ISBD Lithium task force
(2023-12-01)
Hidalgo-Mazzei, Diego
;
Mantingh, Tim
;
Pérez de Mendiola, Xavier
;
Samalin, Ludovic
;
UNDURRAGA FOURCADE, JUAN PABLO
Background: Lithium has long been considered the gold-standard pharmacological treatment for the maintenance treatment of bipolar disorders (BD) which is supported by a wide body of evidence. Prior research has shown a steady decline in lithium prescriptions during the last two decades. We aim to identify potential factors explaining this decline across the world with an anonymous worldwide survey developed by theInternational Society for Bipolar Disorders (ISBD) Task Force “Role of Lithium in Bipolar Disorders” anddistributed by diverse academic and professional international channels. Results: A total of 886 responses were received of which 606 completed the entirequestionnaire while 206 completed it partially. Respondents were from 43 different countries comprising allcontinents. Lithium was the most preferred treatment option for the maintenance of BD patients (59%). The mostrelevant clinical circumstances in which lithium was the preferred option were in patients with BD I (53%), afamily history of response (18%), and a prior response during acute treatment (17%). In contrast, Lithium wasnot the preferred option in case of patients´ negative beliefs and/or attitudes towards lithium (13%), acuteside-effects or tolerability problems (10%) and intoxication risk (8%). Clinicians were less likely to preferlithium as a first option in BD maintenance phase when practising in developing economy countries [X2 (1,N = 430) = 9465, p = 0.002)] and private sectors [X2 (1, N = 434) = 8191, p = 0.004)]. Conclusions: Clinicians’ preferences and attitudes towards the use of lithium in the maintenancetreatment of bipolar disorders appear to be affected by both the patients’ beliefs and the professionalcontexts where clinicians provide their services. More research involving patients is needed for identifyingtheir attitudes toward lithium and factors affecting its use, particularly in developing economies.
Scopus© Citations 28 1
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An integrated multi-criteria decision analysis and optimization modeling approach to spatially operational road repair decisions
(2021)
Sättar Ezzati
;
PALMA INFANTE, CRISTIAN DERECK
;
Pete Bettinger
;
Ljusk Ola Eriksson
;
Anjali Awasthi
In this study, we developed a generic cost-effective approach for spatially explicit decision support involving the allocation of road repair treatments. The approach begins with an assessment of the existing road condition to identify the extent of environmental impacts and to determine road repair regimes in a subjective manner using group-decision making efforts. An integer programming model is then formulated by combining expert opinions with operational costs to guide repair schedules required for each road segment at the operational planning level. To demonstrate model performance, we applied it to a 400 km<jats:sup>2</jats:sup> landscape consisting of 289 km of paved roads in the mountainous region of the Hyrcanian forests in Iran. We assessed sensitivity of the inputs, such as weight verification, budgetary limitations, and rehabilitation weights. The results of the subjective analysis show that 76% of the roads analyzed in these forests must be prioritized to receive treatments as intended for logistical purposes. Incorporating the extent of environmental dimensions into operational costs allows us to generate an optimal tradeoff curve by selecting an appropriate treatment for segments of a road network. The approach demonstrated here can be used to design detailed alternative solutions for addressing spatially-informed road decisions under various terrain conditions.
4Scopus© Citations 5
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Effect-Site Target-Controlled Infusion in the Obese: Model Derivation and Performance Assessment
(2018)
Luis I. Cortínez
;
Pablo Sepúlveda
;
Augusto Rolle
;
Pauline Cottin
;
Alexandre Guerrini
3Scopus© Citations 17

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