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Item type:Publication, Hantavirus in humans: a review of clinical aspects and management(2023); Scopus© Citations 77 79 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker(2023); ; ; Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, the role of the pulmonary epithelium in HCPS pathogenesis remains unclear. This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe HCPS, challenging the prevailing view that endothelial dysfunction is the sole driver of this syndrome. We conducted a cross-sectional study on critically ill HCPS patients, categorizing them into mild HCPS, severe HCPS, and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between the severe HCPS group and controls. Our findings suggest that sRAGE holds promise as an indicator of pulmonary epithelial injury in HCPS and may aid in tracking disease progression and guiding therapeutic strategies. This study brings clarity on the importance of investigating the pulmonary epithelium’s role in HCPS pathogenesis, offering potential avenues for enhanced diagnostic precision and support in this critical public health concern.1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Broad and potently neutralizing monoclonal antibodies isolated from human survivors of New World hantavirus infection(2021)Scopus© Citations 23 2 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Proteinuria in Hantavirus Cardiopulmonary Syndrome: A Frequent Finding Linked To Mortality(2021); ; 27Scopus© Citations 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Comparison of VSV Pseudovirus and Focus Reduction Neutralization Assays for Measurement of Anti-Andes orthohantavirus Neutralizing Antibodies in Patient Samples(2020); 4Scopus© Citations 9 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Targeted high volume hemofiltration could avoid extracorporeal membrane oxygenation in some patients with severe Hantavirus cardiopulmonary syndrome(2021); Scopus© Citations 10 1 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Mother-to-Child Transmission of Andes Virus through Breast Milk, Chile1(2020)Scopus© Citations 17 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Meeting report: Eleventh International Conference on Hantaviruses(2020)Scopus© Citations 2 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A Single-Nucleotide Polymorphism of αVβ3 Integrin Is Associated with the Andes Virus Infection Susceptibility(2019)Scopus© Citations 12 4 - Some of the metrics are blocked by yourconsent settings
Item type:Publication, A 19 Year Analysis of Small Mammals Associated with Human Hantavirus Cases in Chile(2019)<jats:p>Small mammals present in areas where hantavirus cardiopulmonary syndrome (HCPS) cases had occurred in central and southern Chile were captured and analyzed to evaluate the abundance of rodents and seroprevalence rates of antibodies to Andes orthohantavirus (ANDV). Sampling areas ranged from the Coquimbo to Aysén regions (30–45° S approx.) regions. Ninety-two sites in peridomestic and countryside areas were evaluated in 19 years of sampling. An antibody against ANDV was detected by strip immunoassay in 58 of 1847 specimens captured using Sherman traps. Of the eleven species of rodents sampled, Abrothrix olivacea, Oligoryzomys longicaudatus and Abrothrix hirta were the most frequently trapped. O. longicaudatus had the highest seropositivity rate, and by logistic regression analysis, O. longicaudatus of at least 60 g had 80% or higher probability to be seropositive. Sex, age and wounds were significantly related to seropositivity only for O. longicaudatus. Across administrative regions, the highest seropositivity was found in the El Maule region (34.8–36.2° S), and the highest number of HCPS cases was registered in the Aysén region. Our results highlight the importance of long term and geographically extended studies, particularly for highly fluctuating pathogens and their reservoirs, to understand the implications of the dynamics and transmission of zoonotic diseases in human populations.</jats:p>Scopus© Citations 8 1