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A Third Dose of SARS-CoV-2 mRNA Vaccine Improves Immune Response in Chronic Kidney Disease Patients
(2023)
POLI HARLOWE, MARIA CECILIA BERTA
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VIAL COX, MARIA CECILIA
;
REY JURADO, EMMA
;
Natalia González
;
CORTES SALINAS, LINA JIMENA
<jats:p>Chronic kidney disease (CKD) patients have an increased risk of morbidity and mortality following SARS-CoV-2 infection. Vaccination in these patients is prioritized, and monitoring of the immune response is paramount to define further vaccination strategies. This prospective study included a cohort of 100 adult CKD patients: 48 with kidney transplant (KT) and 52 on hemodialysis without prior COVID-19. The patients were assessed for humoral and cellular immune responses after four months of an anti-SARS-CoV-2 primary two-dose vaccination scheme (CoronaVac or BNT162b2) and one month after a booster third dose of BNT162b2 vaccine. We identified poor cellular and humoral immune responses in the CKD patients after a primary vaccination scheme, and these responses were improved by a booster. Robust polyfunctional CD4+ T cell responses were observed in the KT patients after a booster, and this could be attributed to a higher proportion of the patients having been vaccinated with homologous BNT162b2 schemes. However, even after the booster, the KT patients exhibited lower neutralizing antibodies, attributable to specific immunosuppressive treatments. Four patients suffered severe COVID-19 despite three-dose vaccination, and all had low polyfunctional T-cell responses, underscoring the importance of this functional subset in viral protection. In conclusion, a booster dose of SARS-CoV-2 mRNA vaccine in CKD patients improves the impaired humoral and cellular immune responses observed after a primary vaccination scheme.</jats:p>
8Scopus© Citations 5
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Effectiveness of an inactivated SARS-CoV-2 vaccine in children and adolescents: a large-scale observational study
(2023)
Alejandro Jara
;
Eduardo A. Undurraga
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Juan Carlos Flores
;
José R. Zubizarreta
;
Cecilia González
7Scopus© Citations 15
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The added effect of non-pharmaceutical interventions and lifestyle behaviors on vaccine effectiveness against severe COVID-19 in Chile: A matched case-double control study
(2023)
Cinthya Urquidi
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Emilio Santelices
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Anne J. Lagomarcino
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María Teresa Valenzuela
;
Nicolás Larrañaga
Scopus© Citations 5 3
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Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study
(2022)
Minggui Wang
;
Michelle Earley
;
Liang Chen
;
Blake M Hanson
;
Yunsong Yu
Scopus© Citations 226 7
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Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons
(2022)
Claudia M. Lucero
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Juan Prieto-Villalobos
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Lucas Marambio-Ruiz
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Javiera Balmazabal
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Tanhia F. Alvear
<jats:p>Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes damage and activation of mesangial cells (MCs), eliciting the production of large amounts of vasoactive and proinflammatory agents. Accordingly, the activation of AT1 receptors by the vasoactive molecule angiotensin II (AngII) contributes to the pathogenesis of renal damage, which is mediated mostly by the dysfunction of intracellular Ca2+ ([Ca2+]i) signaling. Similarly, inflammation entails complex processes, where [Ca2+]i also play crucial roles. Deregulation of this second messenger increases cell damage and promotes fibrosis, reduces renal blood flow, and impairs the glomerular filtration barrier. In vertebrates, [Ca2+]i signaling depends, in part, on the activity of two families of large-pore channels: hemichannels and pannexons. Interestingly, the opening of these channels depends on [Ca2+]i signaling. In this review, we propose that the opening of channels formed by connexins and/or pannexins mediated by AngII induces the ATP release to the extracellular media, with the subsequent activation of purinergic receptors. This process could elicit Ca2+ overload and constitute a feed-forward mechanism, leading to kidney damage.</jats:p>
5Scopus© Citations 18
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Toma de decisiones en hemodiálisis crónica: estudio cualitativo en adultos mayores
(2020)
María Isabel Catoni
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Sofía P. Salas
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ROESSLER BONZI, EMILIO JOSE
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Andrés Valdivieso
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Antonio Vukusich
7 1Scopus© Citations 2
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Long-Term Oncological and Functional Outcomes After Robot-Assisted Partial Nephrectomy for Clinically Localized Renal Cell Carcinoma
(2022)
Hugo Otaola-Arca
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Alfred Krebs
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Hugo Bermúdez
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Raúl Lyng
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Marcelo Orvieto
Scopus© Citations 8 2
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El riñón del niño prematuro: riesgos a largo plazo
(2020)
Felipe Cavagnaro SM.
<jats:p>El recién nacido prematuro se enfrenta a las condiciones extrauterinas con sistemas aún inmaduros, tanto anatómica como fisiológicamente. El riñón termina de desarrollarse a finales del tercer trimestre del embarazo, por lo que está especialmente expuesto a alterar su desarrollo normal en caso de nacer en forma prematura. Esta situación puede condicionar, entre otras consecuencias, una menor masa renal funcional y cambios microvasculares que representan un riesgo elevado de hipertensión arterial y daño renal crónico en el largo plazo. En el presente artículo se analiza la evidencia existente actual sobre estos riesgos en los prematuros y se ofrece un esquema de seguimiento de estos niños desde el punto de vista nefrológico.</jats:p>
9Scopus© Citations 5
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Análisis de sobrevida en pacientes incidentes de hemodiálisis en Chile, 2013-2019
(2020)
Rodrigo A. Sepúlveda
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Andrés Pavlovic
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Oscar Corsi
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Aquiles Jara
17Scopus© Citations 3
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FREE WATER TRANSPORT AND ITS ASSOCIATION WITH CARDIOVASCULAR STATUS IN CHILDREN ON PERITONEAL DIALYSIS
(2019)
Lilian Bolte
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Maria Jose Ibacache
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Francisco Cano
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DELGADO BECERRA, OROZIMBA IRIS
<jats:sec><jats:title>Background</jats:title><jats:p>Volume overload is one of the most important factors associated with left ventricular hypertrophy (LVH) and cardiovascular disease in chronic peritoneal dialysis (PD) patients. MiniPET is a reliable tool to evaluate free water transport (FWT). In a clinical setting, the significance of FWT has not been evaluated in terms of outcome in children on PD. The objective was to define a FWT value of clinical significance in children on PD, fixing its relationship to left ventricular mass index (LVMI) as a well-known outcome parameter.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>MiniPET was performed with 3.86% glucose, 1-h long, to measure FWT in PD patients > 6 years old. An echocardiogram (ECG) was performed within 2 months of the MiniPET. Left ventricular hypertrophy was defined as LVMI ≥ 38.6 g/height<jats:sup>2.7</jats:sup>(95th percentile). Receiver operating characteristic curve (ROC) analysis was used to determine the cut-off value of FWT searching the highest sensitivity and specificity to differentiate patients with normal/abnormal LVMI. A p < 0.05 was considered significant.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Forty-six studies were performed on 32 patients, 16 males; mean age 11.59 ± 3.07 years. Mean normalized FWT (nFWT) was 144.4 ± 84.8 mL/m<jats:sup>2</jats:sup>, corresponding to 46.7% of total ultrafiltration. Mean LVMI was 42 ± 11.3 g/m<jats:sup>2.7</jats:sup>with a negative correlation to nFWT ( p < 0.01). Eighteen out of 32 patients had LVH. The ROC analysis (nFWT vs LVMI) showed an area under the curve of 0.71 (95% confidence interval [CI], 0.53 – 0.89; p = 0.04), allowing a cut-off nFWT value of 110 mL/m<jats:sup>2</jats:sup>to be defined, dividing the population into 2 groups of patients according to the LVMI cut-off value of 38,6 g/m<jats:sup>2.7</jats:sup>.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The nFWT showed an inverse correlation to LVMI. A nFWT value < 110 mL/m<jats:sup>2</jats:sup>was significantly associated with LVH. The negative relationship observed between nFWT and LVMI, and the cut-off level for nFWT according to the 95th percentile of LVMI, suggest that the regular evaluation of nFWT could become a useful tool in assessing the capacity of PD treatment to keep patients’ volume status under control, avoiding cardiovascular impairment.</jats:p></jats:sec>
24Scopus© Citations 1

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