REY JURADO, EMMA

Preferred name

REY JURADO, EMMA

Main Affiliation

Facultad de Medicina Clínica Alemana Universidad del Desarrollo

emmarey@udd.cl

ORCID

0000-0003-4146-7785

Scopus Author ID

50562073000

Now showing 1 - 10 of 11

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Tracking NK and Memory T Cell Dynamics in Children Affected by Multisystem Inflammatory Syndrome (MIS-C)
(Rockefeller University Press, 2025-12-22)
González, Natalia
;
Astudillo, Camila
;
Espinosa, Yazmín
;
Cerda-Castro, Paz
;
Araya, Juan Pablo
Background Multisystem inflammatory syndrome in children (MIS-C) is a severe condition that arises 4–6 weeks after SARS-CoV-2 exposure, marked by persistent fever, mucocutaneous symptoms, cardiac involvement, and shock. Natural killer (NK) cells are thought to contribute during the acute phase due to their antiviral and immunoregulatory roles, but their phenotype during recovery is not well defined. An expansion of TCR Vβ21.3+ T cells has been observed during acute MIS-C, though their long-term presence and significance remain unclear. Methods Peripheral blood mononuclear cells (PBMCs) were collected from 4 healthy pediatric controls, 4 febrile (non-COVID) controls, 4 children with acute COVID-19, 9 with acute MIS-C, 8 MIS-C convalescents (6–12 months), and 6 long-term MIS-C convalescents (4 years). TCR Vβ21.3 expression was analyzed using a T cell panel (CD3, CD4, CD8, CD27, CD45RA, TCR Vβ21.3). NK cell phenotype was assessed after co-culture with K562 cells using markers including CD56, CD3, CD16, CXCR6, Ki67, NKG2D, NKG2C, and CD158. Results NK cells from acute MIS-C patients showed decreased CD57, CD158, and CD107a, along with increased NKG2D expression. Clustering analysis revealed a unique NK cell population exclusive to acute MIS-C, defined by absent CD107a and elevated CXCR6 and Ki67. Most alterations resolved within 6–12 months, except CD158, which remained low even after 4 years. TCR Vβ21.3+ T cells persisted for up to a year but were undetectable at 4 years. Conclusions MIS-C triggers a transient NK phenotype marked by reduced cytotoxicity and increased activation, suggesting a hyperactivated or dysregulated immune profile. Persistent downregulation of the inhibitory receptor CD158 may indicate prolonged NK activation. TCR Vβ21.3+ T cells appear to be short lived. Further long-term studies with larger cohorts are needed to validate these findings.
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Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia
(2022)
Matilde I. Conte
;
M. Cecilia Poli
;
Angelo Taglialatela
;
Giuseppe Leuzzi
;
Ivan K. Chinn
9Scopus© Citations 18
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Functional Genetics in Inborn Errors of Immunity
(2021)
Emma Rey-Jurado
;
POLI HARLOWE, MARIA CECILIA BERTA
3Scopus© Citations 9
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Multicenter Study to Determine the Immune Response to the Vaccine Against SARS COV-2, in Patients With Chronic Kidney Disease on Dialysis and Kidney Transplants
(2022)
CAMILO ERNESTO ULLOA TESSER
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POLI HARLOWE, MARIA CECILIA BERTA
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REY JURADO, EMMA
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VIAL COX, MARIA CECILIA
;
CORTES SALINAS, LINA JIMENA
1
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Deep immunophenotyping reveals biomarkers of multisystemic inflammatory syndrome in children in a Latin American cohort
(2022)
REY JURADO, EMMA
;
Yazmin Espinosa
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Camila Astudillo
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CORTES SALINAS, LINA JIMENA
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HORMAZABAL CASTILLO, JUAN PATRICIO
Scopus© Citations 16 8
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Dataset - Multiomics approach identifies novel age-, time- and treatment-related immunopathological signatures in MIS-C and pediatric COVID-19
(ZENODO, 2021)
VIAL COX, MARIA CECILIA
;
POLI HARLOWE, MARIA CECILIA BERTA
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REY JURADO, EMMA
11
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Dataset - Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
(ZENODO, 2022)
VIAL COX, MARIA CECILIA
;
POLI HARLOWE, MARIA CECILIA BERTA
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REY JURADO, EMMA
15
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Multicenter analysis of neutrophil extracellular trap dysregulation in adult and pediatric COVID-19
(2022)
Carmelo Carmona-Rivera
;
Yu Zhang
;
Kerry Dobbs
;
Tovah E. Markowitz
;
Clifton L. Dalgard
13Scopus© Citations 30
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Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C
(2022)
Peter D. Burbelo
;
Riccardo Castagnoli
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Chisato Shimizu
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Ottavia M. Delmonte
;
Kerry Dobbs
<jats:p>The antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren’s syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring <jats:italic>in vivo</jats:italic> decay of the autoantibodies in MIS-C children showed that the IVIG-derived Ro52, Ro60, and La autoantibodies declined to undetectable levels by 45-60 days, but gastric ATPase autoantibodies declined more slowly requiring &gt;100 days until undetectable. Further testing of IgG and/or IgA antibodies against a subset of potential targets identified by published autoantigen array studies of MIS-C failed to detect autoantibodies against most (16/18) of these proteins in patients with MIS-C who had not received IVIG. However, Troponin C2 and KLHL12 autoantibodies were detected in 2 of 20 and 1 of 20 patients with MIS-C, respectively. Overall, these results suggest that IVIG therapy may be a confounding factor in autoantibody measurements in MIS-C and that antibodies against antigens associated with autoimmune diseases or other human proteins are uncommon in MIS-C.</jats:p>
1Scopus© Citations 31
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Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19
(2022)
Keith Sacco
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Riccardo Castagnoli
;
Svetlana Vakkilainen
;
Can Liu
;
Ottavia M. Delmonte
Scopus© Citations 204 11

REY JURADO, EMMA

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