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Hydrogen Bond Contribution to Preferential Solvation in SNAr Reactions
(2013)
Rodrigo Ormazabal-Toledo
;
José G. Santos
;
Paulina Ríos
;
Enrique A. Castro
;
Paola R. Campodónico
Scopus© Citations 21 1
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Specific nucleophile–electrophile interactions in nucleophilic aromatic substitutions
(2013)
Rodrigo Ormazábal-Toledo
;
Renato Contreras
;
Ricardo A. Tapia
;
CAMPODONICO GALDAMES, PAOLA ROSSANA
Scopus© Citations 30
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Proteomic Analysis of Niemann-Pick Type C Hepatocytes Reveals Potential Therapeutic Targets for Liver Damage
(2021)
Elisa Balboa
;
Tamara Marín
;
Juan Esteban Oyarzún
;
Pablo S. Contreras
;
Robert Hardt
<jats:p>Niemann-Pick type C disease (NPCD) is a lysosomal storage disorder caused by mutations in the NPC1 gene. The most affected tissues are the central nervous system and liver, and while significant efforts have been made to understand its neurological component, the pathophysiology of the liver damage remains unclear. In this study, hepatocytes derived from wild type and Npc1−/− mice were analyzed by mass spectrometry (MS)-based proteomics in conjunction with bioinformatic analysis. We identified 3832 proteins: 416 proteins had a p-value smaller than 0.05, of which 37% (n = 155) were considered differentially expressed proteins (DEPs), 149 of them were considered upregulated, and 6 were considered downregulated. We focused the analysis on pathways related to NPC pathogenic mechanisms, finding that the most significant changes in expression levels occur in proteins that function in the pathways of liver damage, lipid metabolism, and inflammation. Moreover, in the group of DEPs, 30% (n = 47) were identified as lysosomal proteins and 7% (n = 10) were identified as mitochondrial proteins. Importantly, we found that lysosomal DEPs, including CTSB/D/Z, LIPA, DPP7 and GLMP, and mitocondrial DEPs, AKR1B10, and VAT1 had been connected with liver fibrosis, damage, and steatosis in previous studies, validiting our dataset. Our study found potential therapeutic targets for the treatment of liver damage in NPCD.</jats:p>
Scopus© Citations 9 1
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Changes in the SNAr reaction mechanism brought about by preferential solvation
(2015)
Jazmín Alarcón-Espósito
;
Ricardo A. Tapia
;
Renato Contreras
;
CAMPODONICO GALDAMES, PAOLA ROSSANA
For model SNAr reactions in mixtures of acetonitrile and water, we found preferential solvation in favor of the aqueous phase.
Scopus© Citations 20 2
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Mechanistic pathways of aromatic nucleophilic substitution in conventional solvents and ionic liquids
(2014)
Marcela Gazitúa
;
Ricardo A. Tapia
;
Renato Contreras
;
CAMPODONICO GALDAMES, PAOLA ROSSANA
Solvation effects on the reaction mechanism for nucleophilic substitution reactions have been kinetically evaluated in conventional solvents and ionic liquids.
1Scopus© Citations 44
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Mechanism for the SNAr reaction of atrazine with endogenous thiols: experimental and theoretical study
(2017)
K. Calfumán
;
S. Gallardo-Fuentes
;
R. Contreras
;
R. A. Tapia
;
CAMPODONICO GALDAMES, PAOLA ROSSANA
The mechanism for the SNAr reaction of atrazine with endogenous thiols: a stepwise or concerted process?
11Scopus© Citations 9

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