ADAR-Mediated A>I(G) RNA Editing in the Genotoxic Drug Response of Breast Cancer
Journal
International Journal of Molecular Sciences
ISSN
1422-0067
Date Issued
2024
Author(s)
Yanara A. Bernal
Eduardo Durán
Eduardo A. Sagredo
Type
journal-article
Abstract
<jats:p>Epitranscriptomics is a field that delves into post-transcriptional changes. Among these modifications, the conversion of adenosine to inosine, traduced as guanosine (A>I(G)), is one of the known RNA-editing mechanisms, catalyzed by ADARs. This type of RNA editing is the most common type of editing in mammals and contributes to biological diversity. Disruption in the A>I(G) RNA-editing balance has been linked to diseases, including several types of cancer. Drug resistance in patients with cancer represents a significant public health concern, contributing to increased mortality rates resulting from therapy non-responsiveness and disease progression, representing the greatest challenge for researchers in this field. The A>I(G) RNA editing is involved in several mechanisms over the immunotherapy and genotoxic drug response and drug resistance. This review investigates the relationship between ADAR1 and specific A>I(G) RNA-edited sites, focusing particularly on breast cancer, and the impact of these sites on DNA damage repair and the immune response over anti-cancer therapy. We address the underlying mechanisms, bioinformatics, and in vitro strategies for the identification and validation of A>I(G) RNA-edited sites. We gathered databases related to A>I(G) RNA editing and cancer and discussed the potential clinical and research implications of understanding A>I(G) RNA-editing patterns. Understanding the intricate role of ADAR1-mediated A>I(G) RNA editing in breast cancer holds significant promise for the development of personalized treatment approaches tailored to individual patients’ A>I(G) RNA-editing profiles.</jats:p>
Cite this document
Bernal, Y. A., Durán, E., Solar, I., Sagredo, E. A., & Armisén, R. (2024). Adar-mediated a>i(G) rna editing in the genotoxic drug response of breast cancer. International Journal of Molecular Sciences, 25(13), 7424. https://doi.org/10.3390/ijms25137424
Subjects
rna editing
;
a > i(g)
;
adar1
;
drug response
;
drug resistance
;
breast cancer
;
splicing alteration
;
immune response
;
dna damage repair