Safety, Tolerability, Bioavailability, and Biological Activity of Inhaled Interferon-α2b in Healthy Adults: The IN2COVID Phase I Randomized Trial
Journal
Clinical Drug Investigation
ISSN
1173-2563
1179-1918
Date Issued
2023
Author(s)
Diego Garcia-Huidobro
Carolina Iturriaga
Guillermo Perez-Mateluna
Paula Fajuri
Nicolás Severino
Marcela Urzúa
Juan Pablo Fraga
Javiera de la Cruz
José A. Castro-Rodríguez
Eleanor Fish
Arturo Borzutzky
Juan Pablo Olivo
Katherine Suisbert
Andrea Cruz
Katterine Perez
Romina Valdivieso
Diego Navarro
Francisco Pereira
Vanessa Monge
Marisol Dibarrart
Krisbeth Salazar
Morgan Bracho
Lidia Pontanilla
Type
Resource Types::text::journal::journal article
Subjects
adult
;
biological availability
;
covid-19
;
double-blind method
;
humans
;
interferon alpha-2
;
interferon-alpha
;
alpha interferon
;
alpha2b interferon
;
ap 003
;
placebo
;
alpha interferon
;
alpha2 interferon
;
interferon-alpha2b
;
adult
;
article
;
biological activity
;
bradycardia
;
clinical article
;
controlled study
;
coronavirus disease 2019
;
coughing
;
dizziness
;
drug bioavailability
;
drug safety
;
drug tolerability
;
dry nose
;
epistaxis
;
female
;
headache
;
human
;
hypotension
;
loose feces
;
male
;
nebulization
;
phase 1 clinical trial
;
prospective study
;
randomized controlled trial
;
real time polymerase chain reaction
;
rhinorrhea
;
rna blood level
;
side effect
;
sore throat
;
tachycardia
;
tachypnea
;
visual analog scale
;
vital sign
;
bioavailability
;
clinical trial
;
coronavirus disease 2019
;
double blind procedure