Dietary Advanced Glycation End Products: Their Role in the Insulin Resistance of Aging
Journal
Cells
ISSN
2073-4409
Date Issued
2023
Author(s)
Manuel Portero-Otin
Jaime Uribarri
Type
Resource Types::text::journal::journal article
URL Institutional Repository
Abstract
<jats:p>Insulin resistance (IR) is commonly observed during aging and is at the root of many of the chronic nontransmissible diseases experienced as people grow older. Many factors may play a role in causing IR, but diet is undoubtedly an important one. Whether it is total caloric intake or specific components of the diet, the factors responsible remain to be confirmed. Of the many dietary influences that may play a role in aging-related decreased insulin sensitivity, advanced glycation end products (AGEs) appear particularly important. Herein, we have reviewed in detail in vitro, animal, and human evidence linking dietary AGEs contributing to the bodily burden of AGEs with the development of IR. We conclude that numerous small clinical trials assessing the effect of dietary AGE intake in combination with strong evidence in many animal studies strongly suggest that reducing dietary AGE intake is associated with improved IR in a variety of disease conditions. Reducing AGE content of common foods by simple changes in culinary techniques is a feasible, safe, and easily applicable intervention in both health and disease. Large-scale clinical trials are still needed to provide broader evidence for the deleterious role of dietary AGEs in chronic disease.</jats:p>
Subjects
glycation
;
inflammation
;
insulin resistance
;
oxidative stress
;
ultraprocessed foods
;
aging
;
animals
;
dietary advanced glycation end products
;
glycation end products, advanced
;
humans
;
inflammation
;
insulin resistance
;
oxidative stress
;
advanced glycation end product receptor
;
dietary advanced glycation end product
;
glucose transporter 4
;
high density lipoprotein cholesterol
;
immunoglobulin enhancer binding protein
;
interleukin 10
;
interleukin 18
;
malonaldehyde
;
methylglyoxal
;
phosphatidylinositol 3 kinase
;
pyridoxamine
;
stress activated protein kinase
;
toll like receptor
;
tumor necrosis factor
;
advanced glycation end product
;
blood glucose monitoring
;
body composition
;
body mass
;
cardiovascular risk
;
diabetes mellitus
;
dietary fiber
;
enzyme activity
;
enzyme linked immunosorbent assay
;
glucose blood level
;
glucose tolerance
;
glucose transport
;
glycemic index
;
homeostasis model assessment
;
human
;
hyperglycemia
;
hypoglycemia
;
immunomodulation
;
inflammation
;
innate immunity
;
insulin blood level
;
insulin dependent diabetes mellitus
;
insulin release
;
insulin resistance
;
insulin treatment
;
intestine flora
;
lipid metabolism
;
mouse
;
non insulin dependent diabetes mellitus
;
nonhuman
;
oxidative stress
;
protein structure
;
review
;
signal transduction
;
ultra-processed food
;
aging
;
animal
;
inflammation
;
metabolism